2023
DOI: 10.1016/j.tranon.2022.101569
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Telomerase inhibitor MST-312 and quercetin synergistically inhibit cancer cell proliferation by promoting DNA damage

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Cited by 14 publications
(8 citation statements)
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“…However, the molecular mechanism by which hTERT and hTR are assembled into a functional ribonucleoprotein is unknown (Bachand, Kukolj et al 2000, Roake and Artandi 2020). As the mechanism of action of MST-312 is becoming clearer (Seimiya, Oh-hara et al 2002, Fernandes, Gala et al 2023, we speculate that decrease in telomerase activity by MST-312 could be due to interruption of the function of telomerase enzyme or the assembly of the telomerase. MST-312 was not shown to cause telomere damage, rather inhibited the telomerase activity as observed in short term TIF.…”
Section: Discussionmentioning
confidence: 80%
“…However, the molecular mechanism by which hTERT and hTR are assembled into a functional ribonucleoprotein is unknown (Bachand, Kukolj et al 2000, Roake and Artandi 2020). As the mechanism of action of MST-312 is becoming clearer (Seimiya, Oh-hara et al 2002, Fernandes, Gala et al 2023, we speculate that decrease in telomerase activity by MST-312 could be due to interruption of the function of telomerase enzyme or the assembly of the telomerase. MST-312 was not shown to cause telomere damage, rather inhibited the telomerase activity as observed in short term TIF.…”
Section: Discussionmentioning
confidence: 80%
“…However, the molecular mechanism by which hTERT and hTR are assembled into a functional ribonucleoprotein is unknown. [ 43 , 44 ] As the mechanism of action of MST-312 is becoming clearer, [ 8 , 10 , 11 , 45 ] we speculate that a decrease in telomerase activity by MST-312 could be due to interruption of the function of telomerase enzyme or the assembly of the telomerase. MST-312 was not shown to cause telomere damage, rather it inhibited the telomerase activity as observed in short-term TIF.…”
Section: Discussionmentioning
confidence: 99%
“…To assess the cytotoxic effects, 1,000 VSMCs were seeded in a 96-well plate and treated with the natural extracts in a range of 1 and 500 μM, replacing the medium following 72 h treatment. The viability test was performed following 7 days of treatments using the CellTiter-Blue ® Cell Viability Assay kit (Promega), according to the manufacturer's instructions, measuring the fluorescence at 560/590 nm (Fernandes et al, 2023).…”
Section: Cytotoxicity Of Natural Extractsmentioning
confidence: 99%