Telomere Attrition in White Blood Cell Correlating with Cardiovascular Damage

Nakashima, Hisashi; Ozono, Ryoji; Suyama, Chizuko; Sueda, Taijiro; Kambe, Masayuki; Oshima, Tetsuya

doi:10.1291/hypres.27.319

Cited by 55 publications

(41 citation statements)

References 24 publications

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“…Interestingly, exogenous NO reduced human umbilical vein endothelial cell senescence and delayed age-dependent inhibition of telomerase activity, suggesting that telomerase inactivation precedes endothelial cell senescence and that NO prevents age-related downregulation of telomerase activity and delays endothelial cell senescence. 132 Nakashima et al 133 showed by measuring the mean telomere restriction fragment length that telomere lengths in white blood cells shorten in parallel to a decline in endothelial function by FMD in patients with various degrees of cardiovascular damage as well as in healthy subjects.…”

Section: Endothelial Cell Senescencementioning

confidence: 99%

Endothelial dysfunction and hypertension in aging

2012

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Hypertension is one of the common diseases in the elderly. The prevalence of hypertension markedly increases with advancing age. Both aging and hypertension have a critical role in cardiovascular and cerebrovascular complications. Although aging and hypertension, either independently or collectively, impair endothelial function, aging and hypertension may have similar cascades for the pathogenesis and development of endothelial dysfunction. Nitric oxide (NO) has an important role in regulation of vascular tone. Decrease in NO bioavailability by endothelial dysfunction would lead to elevation of blood pressure. An imbalance of reduced production of NO or increased production of reactive oxygen species, mainly superoxide, may promote endothelial dysfunction. One possible mechanism by which the prevalence of hypertension is increased in relation to aging may be advancing endothelial dysfunction associated with aging through an increase in oxidative stress. In addition, endothelial cell senescence is also involved in aging-related endothelial dysfunction. In this review, we focus on recent findings and interactions between endothelial function, oxidative stress and hypertension in aging.

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Section: Endothelial Cell Senescencementioning

confidence: 99%

Endothelial dysfunction and hypertension in aging

2012

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“…2 The telomere length in white blood cells (WBCs) reflects the cumulative burden of oxidative stress and inflammation in the circulation during an individual's lifetime 3 and has been reported to be a useful marker of biological aging of the cardiovascular system. 4,5 Telomere length has been observed to decrease with increases in cardiovascular risk factors such as hypertension, hyperlipidemia, diabetes, obesity and cigarette smoking. 6 We recently showed that the shortening of the telomeres in peripheral leukocytes was accelerated with advancing age 7 and it was also observed in patients with sarcoidosis 8 and Parkinson's disease 9 in the Japanese population.…”

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confidence: 99%

Diagonal Earlobe Crease are Associated With Shorter Telomere in Male Japanese Patients With Metabolic Syndrome A Pilot Study

Higuchi

Maeda

Guan

et al. 2009

Circ J

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Background Diagonal earlobe crease (ELC) have been proposed as a marker of generalized atherosclerosis, so in the present study it was investigated whether individuals with ELC have a shortened telomere, which correlates with an accelerated cell turnover and premature aging, leading to atherosclerosis. Methods and ResultsThe mean terminal restriction fragment (TRF) was determined by Southern blot hybridization in the peripheral blood cells of 34 male Japanese patients with metabolic syndrome (MetS) who were under 70 years of age with (n=17) and without (n=17) bilateral ELC, and assessed the relationship of ELC to atherosclerotic cardiovascular disease (AVD). The results showed that the TRF was shorter in the MetS patients with ELC in comparison to age-and risk-factor-matched MetS patients without ELC (7.6±1.1 kbp vs 8.6±1.2 kbp; P<0.05). ELC were present in 13 patients in the AVD group (n=18), but only 4 patients in the non-AVD group (n=16) had ELC (72.2% and 25% respectively; P<0.05). Conclusions These findings suggest that ELC is a useful dermatological indicator of an accelerated aging process, as suggested by excessive telomere loss, and might be a useful indirect marker of high-risk patients. (Circ J 2009; 73: 274 -279)

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“…Although we did not study telomeres length in vascular cells, it has been demonstrated that circulating blood leucocyte DNA content is predictive of vascular telomere content and also is an accurate surrogate for vascular aging in population studies (Nakashima et al 2004;Wilson et al 2008).…”

Section: Discussionmentioning

confidence: 94%

“…They consist of several thousands of repetitive sequences of TTAGGG that are naturally shortened with each cell division due to the end replication problem (Nakashima et al 2004;Saliques et al 2010). Progressive attrition of telomeres leads to a critical length that triggers the cell arrest phenomenon known as senescence (Khan et al 2012), and due to the universal fact that telomere shorten with age, its study is crucial for understanding mechanisms of age-related diseases (Armanios 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Notably, it has been reported that telomere shortening and oxidative DNA damage in endothelial progenitor cells is higher in coronary artery disease patients with MetS than in those without MetS (Satoh et al 2008). In addition, endothelial damage and atherosclerosis have been shown to be associated with telomere shortening in white blood cells more tightly than chronological aging (Nakashima et al 2004). Nonetheless, there is still a lack of data in this field.…”

Section: Introductionmentioning

confidence: 99%

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Influence of endothelial dysfunction on telomere length in subjects with metabolic syndrome: LIPGENE study

González-Guardia

Yubero‐Serrano

Rangel‐Zúñiga

et al. 2014

AGE

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Previous evidences support that increased oxidative stress (OxS) may play an important role in metabolic syndrome (MetS) and both are closely linked to vascular dysfunction. This study determined whether there is a relationship between endothelial function and relative telomere length (RTL) in MetS subjects. In this crosssectional study from the LIPGENE cohort, a total of 88 subjects (36 men and 52 women) were divided into four groups by quartiles of telomere length. We measured ischemic reactive hyperemia (IRH), total nitrite (NO) and protein carbonyl (PC) plasma levels, F2-isoprostanes urinary levels, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) plasma activities. IRH and NO plasma levels were higher in subjects with longer RTL (quartiles 3 and 4), while PC plasma levels, F2-isoprostanes urinary levels, and GPx and SOD plasma activities were lower in quartile 4 subjects (longest RTL). Additionally, MetS subjects with longer RTL had greater homeostatic model assessment-β level and lower triglycerides plasma levels. Our results suggest that endothelial dysfunction, associated with high levels of OxS, could be entailed in an increment of telomere attrition. Thus, further support of the molecular and cellular mechanisms involved in vascular dysfunction may contribute to the development AGE (2014) 36:9681 DOI 10.1007/s11357-014-9681-9Lorena González-Guardia and Elena María Yubero-Serrano contributed equally to this work. Electronic supplementary material

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Telomere Attrition in White Blood Cell Correlating with Cardiovascular Damage

Cited by 55 publications

References 24 publications

Endothelial dysfunction and hypertension in aging

Endothelial dysfunction and hypertension in aging

Diagonal Earlobe Crease are Associated With Shorter Telomere in Male Japanese Patients With Metabolic Syndrome A Pilot Study

Influence of endothelial dysfunction on telomere length in subjects with metabolic syndrome: LIPGENE study

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