Telomere fusion in Drosophila: The role of subtelomeric chromatin

Marzullo, Marta; Gatti, Maurizio

doi:10.1080/19336934.2015.1131882

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Human Subtelomeres Are Heterochromatic and Control Telomeres Function1

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2019

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“…Taking together all the aforementioned results and considering that telomeres do not show enrichment of heterochromatic marks in most commonly studied human cell lines [13], we conclude that subtelomeric heterochromatin play a relevant role in the biology of human telomeres (Figure 1A). A similar role of subtelomeric heterochromatin can be envisioned for organisms like Arabidopsis thaliana [45,46], yeast [47][48][49][50] or Drosophila melanogaster [51,52].…”

Section: Human Subtelomeres Are Heterochromatic and Control Telomeres Functionmentioning

confidence: 91%

Targeting Cancer through the Epigenetic Features of Telomeric Regions

Vaquero-Sedas

Vega-Palas

2019

Trends in Cell Biology

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The integrity of the chromatin associated with telomeric regions, which include telomeres and subtelomeres, is essential for telomeres function and cell viability. Whereas human subtelomeres are heterochromatic, telomeres are labeled with euchromatic marks like H4K20me1 and H3K27ac in most commonly studied human cell lines. The epigenetic marks of human telomeric regions influence oncogenic processes. Indeed, different drugs that decrease their genome-wide levels are currently being used or tested in specific cancer therapies. These drugs can challenge cancer by altering the function of key cellular proteins. However, they should also compromise oncogenic processes by modifying the epigenetic landscape of telomeric regions. We believe that studies of telomeric chromatin structure and telomeres dysfunction should help to design epigenetic therapies for cancer treatment.

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