Telomere length and associated factors in older adults with hypertension

Liu, Pan; Zhang, Yaxin; Ma, Lina

doi:10.1177/0300060519882570

Cited by 22 publications

(13 citation statements)

References 61 publications

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“…Conceivably, decreased NO and/or increased ET-1 contributes to hypertension development. In accordance with the in vitro experiments and mouse studies above, several studies showed that patients with EH had shorter LTL compared with that in healthy normotensive individuals 25 , 30 - 35 . Unexpectedly, however, the direct analysis of arterial telomere length (ATL) from EH patients and normotensive individuals did not show a difference, which suggests that LTL may not necessarily reflect changes in ATL in EH patients 36 .…”

Section: Introductionsupporting

confidence: 79%

Shorter Leukocyte Telomere Length coupled with lower expression of Telomerase Genes in patients with Essential Hypertension

Cheng¹,

Wang²,

Dai³

et al. 2020

Int. J. Med. Sci.

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Background: The essential hypertension (EH) pathophysiology remains poorly understood. Many studies indicate that reduced leukocyte telomere length (LTL) is involved in the EH pathogenesis, however, the direct analysis of arterial telomere length (ATL) from EH patients and normotensive individuals did not show a difference. To address these discrepant observations between LTL and ATL, we performed comprehensive analyses of LTL, telomerase gene expression and their genetic variants in healthy normotensive controls and EH patients. Methods: Sex-matched 206 EH patients and equal numbers of healthy controls were recruited. LTL, and the expression of two key telomerase components, telomerase reverse transcriptase (TERT) and internal RNA template (TERC) were determined using qPCR. Genetic variants of rs2736100 at the TERT and rs12696304 at the TERC loci were determined using TaqMan genotyping kits. Results: LTL was significantly shorter in EH patients than in their normotensive controls (0.96 ± 0.52 vs 1.19 ± 0.58, P = 0.001). Moreover, TERT and TERC expression in patients' leukocytes were substantially lower compare to that in healthy controls (TERT, 0.98 ± 0.98 vs 1.76 ± 1.75, P = 0.003; TERC, 1.26 ± 1.62 vs 4.69 ± 3.61, P < 0.001). However, there were no differences in the genetic variants of rs2736100 and rs12696304 between patient and control groups. Conclusions: EH patients have significantly shorter LTL, which may result from defective TERT and TERC expression in leukocytes. Collectively, lower telomerase expression contributes to shorter LTL observed in EH patients, and telomerase activators may be considered for EH therapy.

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Section: Introductionsupporting

confidence: 79%

Shorter Leukocyte Telomere Length coupled with lower expression of Telomerase Genes in patients with Essential Hypertension

Cheng¹,

Wang²,

Dai³

et al. 2020

Int. J. Med. Sci.

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“…Low telomerase activity and short LTLs were shown to be associated with atherosclerotic plaque instability and higher risk for coronary heart disease, myocardial infarction or stroke (Yeh and Wang, 2016 ; Tian et al, 2019 ; Zhan and Hägg, 2019 ). Significant associations were observed between the high rate of age-related LTL attrition and hypertension (Liu et al, 2019b ). In a systematic review comprising 119,439 individuals in total, a weak to moderate association between obesity and TL was observed in 39 of 63 included studies; a significant heterogeneity, however, was observed between studies (Mundstock et al, 2015 ).…”

Section: Tl and Diseasementioning

confidence: 99%

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives

2021

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Telomere shortening is a well-known hallmark of both cellular senescence and organismal aging. An accelerated rate of telomere attrition is also a common feature of age-related diseases. Therefore, telomere length (TL) has been recognized for a long time as one of the best biomarkers of aging. Recent research findings, however, indicate that TL per se can only allow a rough estimate of aging rate and can hardly be regarded as a clinically important risk marker for age-related pathologies and mortality. Evidence is obtained that other indicators such as certain immune parameters, indices of epigenetic age, etc., could be stronger predictors of the health status and the risk of chronic disease. However, despite these issues and limitations, TL remains to be very informative marker in accessing the biological age when used along with other markers such as indices of homeostatic dysregulation, frailty index, epigenetic clock, etc. This review article is aimed at describing the current state of the art in the field and at discussing recent research findings and divergent viewpoints regarding the usefulness of leukocyte TL for estimating the human biological age.

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“…Caloric restriction and rapamycin treatment are also involved in anti-aging process, increase in lifespan, improvement of physiological functions, and reduction of pathology ( 137 ). On the other hand, a chronic inflammatory condition such as obesity is associated with decreased size of telomere length and also with increased oxidative stress in cells, leading to early aging and dementia ( 142 , 143 ). Regular physical activity can be associated with decreased levels of oxidative stress and pathological inflammation.…”

Section: Genetic and Epigenetic Factors As Major Determinants Of Immumentioning

confidence: 99%

Inflammaging in Endemic Areas for Infectious Diseases

et al. 2020

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Immunosenescence is marked by a systemic process named inflammaging along with a series of defects in the immunological activity that results in poor responses to infectious agents and to vaccination. Inflammaging, a state of low-grade chronic inflammation, usually leads to chronic inflammatory diseases and frailty in the elderly. However, some elderly escape from frailty and reach advanced age free of the consequences of inflammaging. This process has been called immunological remodeling, and it is the hallmark of healthy aging as described in the studies of centenarians in Italy. The biological markers of healthy aging are still a matter of debate, and the studies on the topic have focused on inflammatory versus remodeling processes and molecules. The sub-clinical inflammatory status associated with aging might be a deleterious event for populations living in countries where chronic infectious diseases are not prevalent. Nevertheless, in other parts of the world where they are, two possibilities may occur. Inflammatory responses may have a protective effect against these infectious agents. At the same time, the long-term consequences of protective immune responses during chronic infections may result in accelerated immunosenescence in these individuals. Therefore, the biological markers of healthy aging can vary according to environmental, cultural, and geographical settings that reflect worldwide, and in a non-biased, non-westernized perspective, the changes that we experience regarding our contacts with microorganisms and the outcomes of such contacts.

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Telomere length and associated factors in older adults with hypertension

Cited by 22 publications

References 61 publications

Shorter Leukocyte Telomere Length coupled with lower expression of Telomerase Genes in patients with Essential Hypertension

Shorter Leukocyte Telomere Length coupled with lower expression of Telomerase Genes in patients with Essential Hypertension

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives

Inflammaging in Endemic Areas for Infectious Diseases

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