Telomere length and frailty in older adults—A systematic review and meta-analysis

Carvalho, Aline Carla Araújo; Mendes, Mário Luis Tavares; Reis, Monique Carla da Silva; Santos, Victor Santana; Tanajura, Diego Moura; Martins-Filho, Paulo Ricardo

doi:10.1016/j.arr.2019.100914

Cited by 36 publications

(17 citation statements)

References 79 publications

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“…So, it is unreasonable that most of the medical guidelines for elderly subjects are still derived from studies of middle-aged. Likewise, there was no significant association between LTL and frailty score, which is consisted with other studies 19 , supporting the hypothesis that telomere length may be not a meaningful biomarker for frailty.…”

Section: Discussionsupporting

confidence: 84%

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Serum branched-chain amino acids are associated with leukocyte telomere length and frailty based on residents from Guangxi longevity county

Zhang

Zhou

Yang

et al. 2020

Sci Rep

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Branched-chain amino acids (BcAAs) and telomere length are biologically associated with healthy aging. However, the association between them and their interaction on frailty remain unclear in humans. Here, a cross-sectional study based on residents from Guangxi longevity county was conducted to investigate the association of serum BCAAs, peripheral leukocyte telomere length (LTL) and frailty. A total of 1,034 subjects aged 20 to 110 years were recruited in the study. The real-time qPCR method and a targeted metabolomics approach based on isotope dilution liquid chromatography tandem mass spectrometry (LC/MS/MS) method were used for measurement of LTL and BCAAs, respectively. A frailty score defined as the proportion of accumulated deficits based on 24 aging-related items was used assess the health status of elderly subjects. First, we found that a higher concentration of BCAAs was significantly associated with longer LTL only in middle-aged subjects, independent of age and BMI (P < 0.05). In the oldest-old subjects, we identified a significantly inverse association between BcAAs and frailty score (P < 0.001), even after adjustment for age and BMI (P < 0.05). Additionally, we recognized a statistically significant synergetic interaction between BCAAs and LTL on frailty score in the oldest-old subjects by the general linear model (P = 0.042), although we did not find any significant association between LTL and frailty score. In summary, our findings suggest a potentially protective effect of circulating BCAAs on LTL and frailty based on the subjects from longevity county in East Asia and indicate a potential synergetic interaction between BCAAs and LTL in healthy aging.

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Section: Discussionsupporting

confidence: 84%

“…Recently, it has been proposed that frailty may lead to premature apoptosis in cells with normal length telomeres 18 . There are also many studies exploring the correlation between telomere length (TL) and frailty in the elderly, but the conclusions are inconsistent, and especially the data for the oldest-old are lacking 19 .…”

mentioning

confidence: 99%

Serum branched-chain amino acids are associated with leukocyte telomere length and frailty based on residents from Guangxi longevity county

Zhang

Zhou

Yang

et al. 2020

Sci Rep

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“…Remains uncertain whether age-related telomere shortening is a cause or merely a consequence of aging-associated diseases (De Meyer et al, 2018). Moreover, despite convincing evidence has been provided for links between TL and specific age-related diseases, no significant relationship was found between the TL and syndrome of aging-related physiological decline (frailty), a geriatric clinical syndrome characterized by marked vulnerability to adverse health outcomes (Zhou et al, 2018;Araújo Carvalho et al, 2019).…”

Section: Tl and Diseasementioning

confidence: 99%

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives

2021

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Telomere shortening is a well-known hallmark of both cellular senescence and organismal aging. An accelerated rate of telomere attrition is also a common feature of age-related diseases. Therefore, telomere length (TL) has been recognized for a long time as one of the best biomarkers of aging. Recent research findings, however, indicate that TL per se can only allow a rough estimate of aging rate and can hardly be regarded as a clinically important risk marker for age-related pathologies and mortality. Evidence is obtained that other indicators such as certain immune parameters, indices of epigenetic age, etc., could be stronger predictors of the health status and the risk of chronic disease. However, despite these issues and limitations, TL remains to be very informative marker in accessing the biological age when used along with other markers such as indices of homeostatic dysregulation, frailty index, epigenetic clock, etc. This review article is aimed at describing the current state of the art in the field and at discussing recent research findings and divergent viewpoints regarding the usefulness of leukocyte TL for estimating the human biological age.

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“…While in cancer the literature is conflicted regarding risk of cancer and TL [7,[21][22][23] with suggestions that perhaps a "Ushaped" risk association may exist between very short and very long telomeres and risk of different types cancer [12,22,24,25]. In two recent papers, there was no association between TL and cognitive function, grip strength, frailty and sarcopenia [13,26]; suggesting that telomere length may not be a marker of all ageing and disease-related traits.…”

Section: Introductionmentioning

confidence: 99%

Aerobic capacity and telomere length in human skeletal muscle and leukocytes across the lifespan

Hiam

Smith

Voisin

et al. 2020

Aging

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A reduction in aerobic capacity and the shortening of telomeres are hallmarks of the ageing process. We examined whether a lower aerobic capacity is associated with shorter TL in skeletal muscle and/or leukocytes, across a wide age range of individuals. We also tested whether TL in human skeletal muscle (MTL) correlates with TL in leukocytes (LTL). Eighty-two recreationally active, healthy men from the Gene SMART cohort (31.4±8.2 years; body mass index (BMI)=25.3±3.3kg/m 2), and 11 community dwelling older men (74.2±7.5yearsold; BMI=28.7±2.8kg/m 2) participated in the study. Leukocytes and skeletal muscle samples were collected at rest. Relative telomere length (T/S ratio) was measured by RT-PCR. Associations between TL, aerobic capacity (VO2 peak and peak power) and age were assessed with robust linear models. Older age was associated with shorter LTL (45% variance explained, P<0.001), but not MTL (P= 0.7). Aerobic capacity was not associated with MTL (P=0.5), nor LTL (P=0.3). MTL and LTL were correlated across the lifespan (rs=0.26, P=0.03). In healthy individuals, age explain most of the variability of LTL and this appears to be independent of individual aerobic capacity. Individuals with longer LTL also have a longer MTL, suggesting that there might be a shared molecular mechanism regulating telomere length.

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Telomere length and frailty in older adults—A systematic review and meta-analysis

Cited by 36 publications

References 79 publications

Serum branched-chain amino acids are associated with leukocyte telomere length and frailty based on residents from Guangxi longevity county

Serum branched-chain amino acids are associated with leukocyte telomere length and frailty based on residents from Guangxi longevity county

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives

Aerobic capacity and telomere length in human skeletal muscle and leukocytes across the lifespan

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