Telomere length and physical performance among older people—The Helsinki Birth Cohort Study

Astrom, Max J.; Bonsdorff, Mikaela von; Perala, Mia-Maria; Salonen, Minna K.; Rantanen, Taina; Kajantie, Eero; Simonen, Mika; Pohjolainen, Pertti; Haapanen, Markus J; Guzzardi, Maria Angela; Iozzo, Patricia; Kautiainen, Hannu; Eriksson, Johan G.

doi:10.1016/j.mad.2019.111145

Cited by 10 publications

(5 citation statements)

References 38 publications

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“…Nevertheless, the authors did find that attrition increased only in older women with high LTPA at baseline but not in men. In another study from Finland, the authors also observed shorter telomere length at follow-up and greater telomere attrition during follow-up time associated with poorer physical performance after adjusting for covariates (age at baseline, smoking status, body mass index at baseline, follow-up time, and educational attainment) in women only [9]. These findings suggest that the association between physical activity and telomere length may be sex-specific.…”

Section: Discussionmentioning

confidence: 89%

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Physical performance and telomere length in older adults

Martínez-Ezquerro,

Ortiz-Ramírez,

García-delaTorre

et al. 2023

Preprint

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BackgroundThe fast-paced aging demographic prompts studying risk factors and markers that could predict healthy aging. Telomere length shows promise for assessing a broad spectrum of aging-related phenotypes.Aim of the studyTo assess the association between physical performance and telomere length in Mexican older adults.MethodsIn this observational cross-sectional study, we recruited 323 older adults affiliated with the Instituto Mexicano del Seguro Social (IMSS) and members of the “Cohort of Obesity, Sarcopenia, and Frailty of Older Mexican Adults’’ (COSFOMA). To assess physical performance, we used the Short Physical Performance Battery (SPPB) and stratified individuals into two groups according to their SPPB score into low ≤7 (L-SPPB) and high >7 (H-SPPB). Absolute telomere length (aTL) was determined by using qPCR. Next, we classified individuals according to their aTL into short ≤4.22 kb (S-TL) and long >4.22 kb (L-TL). For both SPPB and aTL categories, we calculated the mean and adjusted mean by sex, age, marital status, education, remunerated work, smoking, drinking, cognitive decline, depression, and polypharmacy with 95% CI, including the lower and upper CI (LCImeanUCI). We estimated the effect size between physical performance and telomere length with Cohen’s d for unequal group sizes. Also, we calculated the odds ratio with 95% confidence intervals, including the lower and upper CI (LCIORUCI) for physical performance according to telomere length categories.ResultsParticipants in the low physical performance category had significantly shorter telomeres (4.14.44.7mean and3.54.04.5kb adjusted mean, p<0.001), in opposition to the high physical performance category (score >7) with longer telomeres (5.55.75.9mean and4.75.35.8kb adjusted mean, p<0.001), with a medium-to-high telomere length effect size (d= 0.762). Finally, the odds of being classified in the low physical activity category increased2.13.66.1times per kb of telomere (adjOR1.73.36.3, p<0.001) compared to the high physical activity group (p<0.001).ConclusionDecreased physical functioning is associated with lower telomere length. Absolute telomere length (aTL) as a possible biomarker for differential diagnosis of healthy and unhealthy aging should be explored further.

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Section: Discussionmentioning

confidence: 89%

“…Physical performance can be defined as the functional ability of individuals to perform certain physical activities that depend on a variety of factors that positively or negatively affect their health; therefore, it is considered an indicator of health status [9].…”

Section: Introductionmentioning

confidence: 99%

Physical performance and telomere length in older adults

Martínez-Ezquerro,

Ortiz-Ramírez,

García-delaTorre

et al. 2023

Preprint

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“…However, because most somatic cells lack telomerase, the length of their telomeres shortens over time, leading to senescence once the telomeres reach a threshold length. Telomeres shorten at a rate of 20–40 bases every year, and as people get older, they accumulate a high number of senescent cells, which adds to the ageing process ( Starkweather et al, 2014 ; Åström et al, 2019 ). Extrinsic variables can influence telomere shortening rates, such as smoking and vitamin insufficiency, but a balanced lifestyle with correct nutrition, exercise, and certain pharmacological therapies can reduce telomere shortening rates.…”

Section: Effect Of Hbot On Aging and Cellular Regenerationmentioning

confidence: 99%

Hyperbaric oxygen therapy: future prospects in regenerative therapy and anti-aging

Gupta,

Rathored

2024

Front. Aging

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Hyperbaric Oxygen Therapy (HBOT) utilizes 100% oxygen at high atmospheric pressure for clinical applications. HBOT has proven to be an effective supplementary treatment for a variety of clinical and pathological disorders. HBOT’s therapeutic results are based on the physiological effects of increased tissue oxygenation, or improved oxygen bioavailability. HBOT’s current indications in illnesses like as wound healing, thermal or radiation burns, and tissue necrosis point to its function in facilitating the regeneration process. Various research has revealed that HBOT plays a function in vascularization, angiogenesis, and collagen production augmentation. Individual regeneration capacity is influenced by both environmental and genetic factors. Furthermore, the regenerating ability of different types of tissues varies, and this ability declines with age. HBOT affects physiological processes at the genetic level by altering gene expression, delaying cell senescence, and assisting in telomere length enhancement. The positive results in a variety of indications, ranging from tissue regeneration to better cognitive function, indicate that it has enormous potential in regenerative and anti-aging therapy.

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Section: Use Of Telomere Length In Clinical Practice and Caveatsmentioning

confidence: 99%

“…The Helsinki's Birth cohort study has shown that the telomere length appeared to be associated with ageing (10). It was further elaborated that it be used as a marker of ageing in women (10). Till date the available literature suggests that telomere length can provide reliable information on an individual's biological age, disease risk, and overall health status.…”

Section: Use Of Telomere Length In Clinical Practice and Caveatsmentioning

confidence: 99%

Telomere length- A biological marker of ageing

Syed¹

2023

LMRJ

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Telomere length is an indicator of biological age, influenced mainly by oxidative stress and inflammatory conditions. Telomere length shortens with advancing age, however in certain situations this shortening expedites with early senile changes while in other situations it can be delayed resulting in slowing of ageing. Ageing is a factor associated with a number of diseases and also treatment decision of lethal diseases is directly influenced by the age. However, understanding the difference of chorological versus biological age is essential. It is also essential to determine cut-offs of the age by using telomere length.

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Telomere length and physical performance among older people—The Helsinki Birth Cohort Study

Cited by 10 publications

References 38 publications

Physical performance and telomere length in older adults

Physical performance and telomere length in older adults

Hyperbaric oxygen therapy: future prospects in regenerative therapy and anti-aging

Telomere length- A biological marker of ageing

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