Telomere length and vascular wall in patients with Type 2 Diabetes Mellitus

Dudinskaya, Е. N.; Tkacheva, О. N.; Shestakova, Marina Vladimirovna; Браилова, Н. В.; Strazhesko, I. D.; Акашева, Д. У.; Isaykina, O. Yu.; Pokrovskaya, M. S.; Шарашкина, Н. В.; Boytsov, S. А.

doi:10.14341/dm2014331-38

Cited by 8 publications

(1 citation statement)

References 18 publications

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“…Представлены только факторы, продемонстрировавшие статистическую значимость. [46][47][48]. ТКИМ является одним из маркеров раннего сосудистого старения и часто используется в крупных исследованиях, включая генетические, как маркер раннего атеросклероза в связи с относительной простотой, доступностью и неинвазивностью методики измерения [49].…”

Section: результаты и обсуждениеunclassified

Association of AGT, ACE, NOS3, TNF, MMP9, CYBA polymorphism with subclinical arterial wall changes

et al. 2021

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Aim Activation of the renin-angiotensin-aldosterone system, decreased nitric oxide production, chronic inflammation, and oxidative stress result in subclinical changes in the arterial wall, which favor the development of cardiovascular diseases (CVD). The effect of allelic gene variants that encode the proteins participating in pathogenetic pathways of age-associated diseases with subclinical changes in the arterial wall [increased pulse wave velocity (PWV), increased intima-media thickness, endothelial dysfunction (ED), presence of atherosclerotic plaques (ASP)] are understudied. This study analyzed the relationship between AGT, ACE, NOS3 TNF, MMP9, and CYBA gene polymorphism and the presence of subclinical changes in the arterial wall, including the dependence on risk factors for CVD, in arbitrarily healthy people of various age.Material and methods The relationship of polymorphisms с.521С>Т of AGT gene, Ins>Del of AСE gene, с.894G>T of NOS3 gene, – 238G>A of TNF gene, – 1562С>T of MMP9 gene, and c.214Т>С of CYBA gene with indexes of changes in the arterial wall and risk factors for CVD was studied in 160 arbitrarily healthy people by building models of multiple logistic regression and also by analyzing frequencies of co-emergence of two signs with the Pearson chi-squared test (χ2) and Fisher exact test.Results The DD-genotype of Ins>Del ACE gene polymorphism was correlated with increased PWV (p=0.006; odds ratio (OR) =3.41, 95 % confidence interval (CI): 1.48–8.67) and ED (p=0.014; OR=2.60, 95 % CI: 1.22–5.68). The GG genotype of с.894G>T NOS3 gene polymorphism was correlated with ED (p=0.0087; OR=2.65, 95 % CI: 1.26–5.72); the ТТ-genotype of с.894G>T NOS3 gene polymorphism was correlated with ASP (p=0.033; OR=0.034, 95 % CI: 0.001–0.549).Conclusion Polymorphic variants of AСE and NOS3 genes correlated with ED, increased arterial wall stiffness, and the presence of subclinical changes in the arterial wall.

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Section: результаты и обсуждениеunclassified

Association of AGT, ACE, NOS3, TNF, MMP9, CYBA polymorphism with subclinical arterial wall changes

et al. 2021

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The relationship between telomere length and putative markers of vascular ageing: A systematic review and meta-analysis

Kosmopoulos

Chiriacò

Stamatelopoulos

et al. 2022

Mechanisms of Ageing and Development

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The Association Between Telomere Length and Diabetes Mellitus: Accumulated Evidence From Observational Studies

He,

Cao,

et al. 2024

The Journal of Clinical Endocrinology &Amp; Metabolism

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Objective In order to assess the associations between telomere length (TL) and diabetes mellitus (DM), especially type 2 diabetes (T2DM), we performed this systematic review and meta-analysis. Methods PubMed, Embase, and Web of Science were thoroughly searched up to July 11, 2023. The pooled standardized mean difference (SMD) and the 95% confidence interval (CI) were evaluated using the random-effects model. Age, sex, study design, duration of diabetes, region, sample size, and body mass index (BMI) were used to stratify subgroup analyses. Results A total of 37 observational studies involving 18,181 participants from 14 countries were included in the quantitative meta-analysis. In this study, patients with diabetes had shorter TL than the non-diabetic, whether those patients had T1DM (-2.70; 95% CI: -4.47, -0.93; P<0.001), T2DM (-3.70; 95% CI: -4.20, -3.20; P<0.001), or other types of diabetes (-0.71; 95% CI: -1.10, -0.31; P<0.001). Additionally, subgroup analysis of T2DM showed that TL was significantly correlated with age, sex, study design, diabetes duration, sample size, detection method, region, and BMI. Conclusion A negative correlation was observed between TL and DM. To validate this association in the interim, more extensive, superior prospective investigations and clinical trials are required.

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Telomere length and vascular wall in patients with Type 2 Diabetes Mellitus

Cited by 8 publications

References 18 publications

Association of AGT, ACE, NOS3, TNF, MMP9, CYBA polymorphism with subclinical arterial wall changes

Association of AGT, ACE, NOS3, TNF, MMP9, CYBA polymorphism with subclinical arterial wall changes

The relationship between telomere length and putative markers of vascular ageing: A systematic review and meta-analysis

The Association Between Telomere Length and Diabetes Mellitus: Accumulated Evidence From Observational Studies

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