Telomere length is not predictive of dementia or MCI conversion in the oldest old

Zekry, Dina; Herrmann, Françoís; Irminger-Finger, Irmingard; Ortolan, Laura; Genet, Chantal; Vitale, Anna-Maria; Michel, Jean‐Pierre; Gold, Gabriel; Krause, Karl‐Heinz

doi:10.1016/j.neurobiolaging.2008.05.016

Cited by 53 publications

(33 citation statements)

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“…Shorter LTL were found in AD patients [71], but no correlation was found between AD and telomere length of cerebral cells [72]. Moreover, in a longitudinal study LTL was not associated with changes in cognitive status of AD patients after 2 years of follow-up [73].…”

Section: Telomeres and Age-associated Diseasesmentioning

confidence: 83%

The role of telomeres and vitamin D in cellular aging and age-related diseases

Pusceddu

Farrell²,

Pierro

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

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Aging is a complex biological process characterized by a progressive decline of organ functions leading to an increased risk of age-associated diseases and death. Decades of intensive research have identified a range of molecular and biochemical pathways contributing to aging. However, many aspects regarding the regulation and interplay of these pathways are insufficiently understood. Telomere dysfunction and genomic instability appear to be of critical importance for aging at a cellular level. For example, age-related diseases and premature aging syndromes are frequently associated with telomere shortening. Telomeres are repetitive nucleotide sequences that together with the associated sheltrin complex protect the ends of chromosomes and maintain genomic stability. Recent studies suggest that micronutrients, such as vitamin D, folate and vitamin B12, are involved in telomere biology and cellular aging. In particular, vitamin D is important for a range of vital cellular processes including cellular differentiation, proliferation and apoptosis. As a result of the multiple functions of vitamin D it has been speculated that vitamin D might play a role in telomere biology and genomic stability. Here we review existing knowledge about the link between telomere biology and cellular aging with a focus on the role of vitamin D. We searched the literature up to November 2014 for human studies, animal models and in vitro experiments that addressed this topic.

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Section: Telomeres and Age-associated Diseasesmentioning

confidence: 83%

The role of telomeres and vitamin D in cellular aging and age-related diseases

Pusceddu

Farrell²,

Pierro

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…The patients and data collection have been described elsewhere [15,16,17]. Briefly, a representative sample of all consecutive admissions of patients aged 75 years and over in 2004 was selected by randomization, with a sampling fraction of 30% and a computer-generated randomization table.…”

Section: Methodsmentioning

confidence: 99%

High Levels of Comorbidity and Disability Cancel Out the Dementia Effect in Predictions of Long-Term Mortality after Discharge in the Very Old

Zekry

Herrmann

et al. 2011

Dement Geriatr Cogn Disord

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Background/Aims: The relative weight of various etiologies of dementia as predictors of long-term mortality after other risk factors have been taken into account remains unclear. We investigated the 5-year mortality risk associated with dementia in elderly people after discharge from acute care, taking into account comorbid conditions and functionality. Methods: A prospective cohort study of 444 patients (mean age: 85 years; 74% female) discharged from the acute geriatric unit of Geneva University Hospitals. On admission, each subject underwent a standardized diagnostic evaluation: demographic variables, cognitive, comorbid medical conditions and functional assessment. Patients were followed yearly by the same team. Predictors of survival at 5 years were evaluated by Cox proportional hazards models. Results: The univariate model showed that being older and male, and having vascular and severe dementia, comorbidity and functional disability, were predictive of shorter survival. However, in the full multivariate model adjusted for age and sex, the effect of dementia type or severity completely disappeared when all the variables were added. In multivariate analysis, the best predictor was higher comorbidity score, followed by functional status (R² = 23%). Conclusions: The identification of comorbidity and functional impairment effects as predictive factors for long-term mortality independent of cognitive status may increase the accuracy of long-term discharge planning.

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“…in a longitudinal study among large oldest old cohorts. After two years of follow-up, Alzheimer patients did not present significant shorter telomere compared to either demented or normal cognition groups (Zekry et al, 2010). Lof-Ohlin et al compared Vascular demented patients versus Alzheimer patients and did not find any Telomere Length differences between the groups in such a way that it can serve as a predictor for either form of dementia (Lof-Ohlin et al, 2008).…”

Section: Telomere and Alzheimer's Diseasementioning

confidence: 97%