Telomere Shortening in Human Coronary Artery Diseases

Ogami, Masayuki; Ohsawa, Masahiko; Matsuo, Toshihiko; Kayo, Soichiro; Yoshimi, Noriko; Hai, Eishu; Shirai, Nobuyuki; Ehara, Shoichi; Komatsu, Ryushi; Naruko, Takahiko; Ueda, Makiko

doi:10.1161/01.atv.0000117200.46938.e7

Cited by 239 publications

(170 citation statements)

References 40 publications

Supporting

Mentioning

156

Contrasting

Unclassified

Order By: Relevance

“…These findings have been confirmed in other cohorts of patients with coronary disease [59,62]. Not only are WBC telomeres shorter, but telomeres of coronary artery endothelial cells of atherosclerotic plaques are also shorter compared to non-atherosclerotic segments and healthy controls [60].…”

Section: Atherosclerosissupporting

confidence: 65%

“…In addition to the association between telomeres and the risk factors for atherosclerosis, a relationship between telomeres and atherosclerotic disease itself has also been observed [23,[59][60][61][62]. WBC telomere length in patients who had a myocardial infarction before the age of 50 years was shorter than in healthy controls, independently from other atherosclerotic risk factors [23].…”

Section: Atherosclerosismentioning

confidence: 97%

See 1 more Smart Citation

Telomere biology in heart failure

Wong

Boer

Samani

et al. 2008

European J of Heart Fail

View full text Add to dashboard Cite

The incidence and prevalence of cardiovascular disease increases progressively with advancing age. Cardiovascular disease is a major cause of morbidity and mortality in Western Countries. In the near future, as the population ages, it is expected that the population prevalence of cardiovascular disease will increase dramatically, imposing a major social and economical burden on society. Not only is age closely related to the development and progression of cardiovascular disease, but genetic and environmental factors also play an important role. Recently, a chromosomal mechanism, telomere shortening, has been considered a driving force by which genetic and environmental factors jointly affect biological aging, and possibly the risk for developing age-associated diseases. Telomeres are the extreme ends of chromosomes and shorten progressively during every cell cycle and therefore can be considered an indicator of biological age. In heart failure, telomere length is severely reduced. In the current review, we will discuss the emerging role of telomere biology in the pathophysiology of heart failure.

show abstract

Section: Atherosclerosissupporting

confidence: 65%

Section: Atherosclerosismentioning

confidence: 97%

Telomere biology in heart failure

Wong

Boer

Samani

et al. 2008

European J of Heart Fail

View full text Add to dashboard Cite

show abstract

“…A previous study demonstrated that patients with CVD had shortening of total telomere length compared with healthy participants (21). Notably, previous reports have found that total telomere shortening per se causes cellular senescence in vascular endothelial cells (22) and eventually leads to atherosclerotic plaques (23).…”

Section: Discussionmentioning

confidence: 98%

Telomeric G-Tail Length and Hospitalization for Cardiovascular Events in Hemodialysis Patients

Hirashio

Nakashima

Doi

et al. 2014

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Background and objectives Telomeric G-tails play a pivotal role in maintaining the intramolecular loop structure of telomeres. Previous in vitro studies have suggested that the erosion of telomeric G-tails triggers cellular senescence, leading to organ dysfunction and atherosclerosis. The authors recently established a method to measure telomeric G-tail length using a hybridization protection assay. Using this method, this study investigated whether telomeric G-tail length could be used as a novel predictor for future cardiovascular events in hemodialysis patients.Design, setting, participants, & measurements A prospective observational study was performed involving a cohort of 203 Japanese hemodialysis patients to examine the lengths of telomeric G-tails and total telomeres and subsequent cardiovascular events during a median follow-up period of 48 months. The lengths of telomeric G-tails and total telomeres were also measured in 203 participants who did not have CKD and who were age-and sex-matched to hemodialysis patients. ResultsThe lengths of telomeric G-tails and total telomeres were significantly shorter in hemodialysis patients than in control subjects. Telomeric G-tails, but not total telomeres, were independently and negatively associated with clinical history of cardiovascular disease. During follow-up, 80 cardiovascular events occurred. Total telomere length did not predict cardiovascular events. However, the length of telomeric G-tails was associated with new-onset cardiovascular events (hazard ratio per log luminescence signals, 0.12; 95% confidence interval, 0.12 to 0.50) that persisted after adjustment for age, sex, diabetes mellitus, clinical history of cardiovascular disease, inflammation, use of vitamin D, and serum levels of phosphate and intact parathyroid hormone.Conclusions Longer telomeric G-tail length is associated with a lower risk of future cardiovascular events in hemodialysis patients.

show abstract

“…Кроме того, короткие теломеры ассоции-руются с повышенным риском развития ССЗ. В част-ности, ассоциативные связи прослеживаются меж-ду короткими теломерами и АГ [31], хронической сердечной недостаточностью [36], атеросклерозом [37].…”

Section: эффекты низкосолевой диеты на молекулярно-генетическом уровнеunclassified

Low Sodium Diet: Pros and Cons

Драпкина¹,

Shepel²

2015

Racionalʹnaâ farmakoterapiâ v kardiologii

View full text Add to dashboard Cite

О.М. Драпкина‫,٭‬ Р.Н. ШепельПервый Московский государственный медицинский университет им. И.М. Сеченова 119991, Москва, ул. Трубецкая, 8, стр. 2 В настоящее время существуют достаточно противоречивые данные по эффективности низкосолевой диеты с целью профилактики различного рода заболеваний. При этом общепризнанным является факт, что снижение потребления соли необходимо для коррекции высоких цифр артериального давления. Врачу не стоит забывать о том, что степень снижения артериального давления индивидуальна, и не всегда зависит от уровня потребления соли. Кроме того, низкосолевая диета способствует сни-жению скорости укорочения теломер, тем самым замедляя процессы старения. Ключевые слова: теломеры, старение, сердечно-сосудистая система, фактор риска, соль. Currently, there is rather contradictory evidence on the effectiveness of a low sodium diet for the prevention of various diseases. At that, it is a generally accepted fact, that it is necessary to reduce salt intake in order to reduce high blood pressure. An internist should remember that the degree of blood pressure reduction is individual and not always depends on the level of salt intake. Moreover, the low-sodium diet helps to reduce the rate of telomere shortening, thereby slowing down the aging process.

show abstract

Telomere Shortening in Human Coronary Artery Diseases

Cited by 239 publications

References 40 publications

Telomere biology in heart failure

Telomere biology in heart failure

Telomeric G-Tail Length and Hospitalization for Cardiovascular Events in Hemodialysis Patients

Low Sodium Diet: Pros and Cons

Contact Info

Product

Resources

About