2021
DOI: 10.20944/preprints202111.0367.v1
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Telomere Targeting Approaches in Cancer: Over the Length Maintenance.

Abstract: Telomeres are crucial structures that preserve genome stability. Their progressive erosion over rounds of DNA duplication determines senescence of cells and organisms. Telomere length homeostasis is critical for cancer development then telomere maintenance mechanisms are established targets in cancer treatment. Besides telomere elongation, telomere’s dysfunction impinges on intracellular signalling pathways, in particular DNA damage signalling and repair affecting cancer cell survival and proliferati… Show more

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