Telomeres as a molecular marker of male infertility

Boniewska-Bernacka, Ewa; Pańczyszyn, Anna; Cybulska, Natalia

doi:10.1080/14647273.2018.1456682

Cited by 20 publications

(17 citation statements)

References 87 publications

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“…21 Therefore, STL measurement is suggested to predict clinical outcomes. 22 Several studies have demonstrated an impact of lifestyle factors on telomere lengths, mainly in leucocytes (for reviews, see. 23 Lifestyle factors have also been stated to potentially affect sperm quality and fertility.…”

Section: Introductionmentioning

confidence: 99%

Associations of sperm telomere length with semen parameters, clinical outcomes and lifestyle factors in human normozoospermic samples

et al. 2019

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Background: Many studies have demonstrated that lifestyle factors can affect sperm quality and fertility. Sperm telomere length (STL) has been reported as potential biomarker or sperm quality. However, no studies have investigated how lifestyle factors can affect STL and associated clinical outcomes. Objectives:The purpose of this manuscript is to investigate any association between STL with lifestyle factors, semen parameters and clinical outcomes. Materials and methods:Sperm telomere length was measured using real-time PCR in normozoospermic male partners (n = 66) of couples undergoing ART treatment. Each participant also completed a detailed questionnaire about general lifestyle. Linear regression univariate analysis and ANCOVA were performed to respectively determine correlations between STL and study parameters or identify statistically significant differences in STL while controlling for age, BMI and other factors. Results:Using a linear regression model, STL is positively correlated with in vitro fertilization success (n = 65, r = 0.37, P = .004) but not with embryo cleavage rates and post-implantation clinical outcomes including gestational age-adjusted birth weight.No associations were observed between STL and sperm count, concentration or progressive motility. We further found that STL did not associate age, BMI, health or lifestyle factors. Discussion: In somatic cells, the rate of telomere shortening is influenced by a number of lifestyle factors such as smoking, diet and occupation. However, little is known about how lifestyle factors affect STL and subsequently reproductive outcome. Out data suggest that STL might have an important role mechanistically for fertilization rate regardless of sperm parameters and lifestyle factors. Conclusion: The results of this study demonstrate that STL is associated with in vitro fertilization rates, but not with semen parameters nor lifestyle factors. Further How to cite this article: Berneau SC, Shackleton J, Nevin C, et al. Associations of sperm telomere length with semen parameters, clinical outcomes and lifestyle factors in human normozoospermic samples. Andrology. 2020;8:583-593.

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Section: Introductionmentioning

confidence: 99%

Associations of sperm telomere length with semen parameters, clinical outcomes and lifestyle factors in human normozoospermic samples

et al. 2019

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“…This is probably the reason why the aforementioned associations were not observed and STL in patients with normozoospermia was lower than in patients with abnormal semen parameters. In fact, the demonstration that STL is an additional sperm parameter may open new perspectives in the evaluation of infertile males [31,32]. Additional research on men of proven fertility and infertility will clarify the significance of this biomarker also as a quality parameter for semen.…”

Section: Discussionmentioning

confidence: 97%

Sperm Telomere Length in Men with Normal and Abnormal semen Parameters. A Pilot Study

Boniewska-Bernacka

2019

BJSTR

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Objective: Male infertility is a growing social problem. The measurement of telomere length may be a new marker that can help to assess reproductive age of males and assess the chances of in vitro fertilization. Aim:The aim of our study was to investigate whether there are any differences between telomere length in men with normal and abnormal semen parameters. Materials and Methods:Telomere length was analyzed in 17 patients with normal and 28 patients with abnormal semen parameters using the telomeric repeat amplification protocol and Quantitative Real-Time Polymerase Chain Reaction (qPCR).Results: Mean sperm telomere length in all donors was 49±24kbp per haploid genome. However, patients with abnormal semen parameters had significantly longer telomeres compared with patients with normal semen parameters. Higher variability in sperm telomere length was observed in patients with abnormal semen parameters in comparison to patients with normozoospermia. Conclusion:The results suggest that telomere length assessment may be a useful future marker that may help to assess sperm cell fertilization capacity.

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“…For example, sperm telomeres have been reported to both decline [91] and increase [101] with male age in mice Mus musculus, but decrease in rats Rattus norvegicus [104]. In humans, telomere lengths in sperm have been found to increase with male age [92,105] in contrast to the pattern in somatic tissues [106]. How an increase with male age occurs remains unclear [106].…”

Section: (B) Telomere Attrition In the Germlinementioning

confidence: 99%

“…In humans, telomere lengths in sperm have been found to increase with male age [92,105] in contrast to the pattern in somatic tissues [106]. How an increase with male age occurs remains unclear [106]. It could be due to expression of telomerase, or stringent quality control of sperm that results in the removal of an increasing proportion of sperm with short telomeres as males age, or be a consequence of cohort effects or differential survival of male phenotypes [106].…”

Section: (B) Telomere Attrition In the Germlinementioning

confidence: 99%

The deteriorating soma and the indispensable germline: gamete senescence and offspring fitness

2019

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The idea that there is an impenetrable barrier that separates the germline and soma has shaped much thinking in evolutionary biology and in many other disciplines. However, recent research has revealed that the so-called ‘Weismann Barrier’ is leaky, and that information is transferred from soma to germline. Moreover, the germline itself is now known to age, and to be influenced by an age-related deterioration of the soma that houses and protects it. This could reduce the likelihood of successful reproduction by old individuals, but also lead to long-term deleterious consequences for any offspring that they do produce (including a shortened lifespan). Here, we review the evidence from a diverse and multidisciplinary literature for senescence in the germline and its consequences; we also examine the underlying mechanisms responsible, emphasizing changes in mutation rate, telomere loss, and impaired mitochondrial function in gametes. We consider the effect on life-history evolution, particularly reproductive scheduling and mate choice. Throughout, we draw attention to unresolved issues, new questions to consider, and areas where more research is needed. We also highlight the need for a more comparative approach that would reveal the diversity of processes that organisms have evolved to slow or halt age-related germline deterioration.

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Telomeres as a molecular marker of male infertility

Cited by 20 publications

References 87 publications

Associations of sperm telomere length with semen parameters, clinical outcomes and lifestyle factors in human normozoospermic samples

Associations of sperm telomere length with semen parameters, clinical outcomes and lifestyle factors in human normozoospermic samples

Sperm Telomere Length in Men with Normal and Abnormal semen Parameters. A Pilot Study

The deteriorating soma and the indispensable germline: gamete senescence and offspring fitness

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