Telomeres in health and disease

Chatterjee, Shailja

doi:10.4103/jomfp.jomfp_39_16

Cited by 28 publications

(41 citation statements)

References 15 publications

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“…In differentiated mature somatic cells, telomere biology disorders, including dyskeratosis congenita and aplastic anemia. 23,24 In the present study, KTX recipients showed increased expression of TRF2 with no significant difference in telomere length when compared to healthy controls. TRF2 has diverse effects on telomere length.…”

Section: Discussionsupporting

confidence: 47%

“…Members of the shelterin complex, comprising TPP1 , TRF1 , TRF2 , RPA1 , TIN2 , and POT1 , are known to be important regulators of both telomere elongation and stability. Depletion of shelterin proteins TRP1 , TRP2 , TTP1 , and TIN2 has been shown to cause telomeric DNA damage and associate with telomere biology disorders, including dyskeratosis congenita and aplastic anemia . In the present study , KTX recipients showed increased expression of TRF2 with no significant difference in telomere length when compared to healthy controls.…”

Section: Discussionmentioning

confidence: 94%

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Telomere length regulators are activated in young men after pediatric kidney transplantation compared to healthy controls and survivors of childhood cancer—A cross‐sectional study

Endén

Tainio

Hou

et al. 2019

Pediatric Transplantation

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Chronic diseases are known to cause premature aging and frailty. Data about telomere length and telomere length‐regulating proteins after pediatric KTx are scarce. Leukocyte telomere length and gene expression level of eight telomere‐binding proteins were analyzed in 20 KTx recipients, eight childhood NBL survivors, and nine healthy controls. The influence of key clinical parameters on telomere length and on regulators of telomere length was evaluated. The telomere length in the KTx recipients tended to be shorter (0.53 AU) than in the healthy controls (0.64 AU) but longer than in the NBL survivors (0.38 AU). There was no significant difference in telomere length between the NBL survivors and the KTx recipients (P = .110). The gene expression level of telomere length‐preserving protein RPA1 was significantly higher in the KTx recipients than among the NBL survivors or healthy controls, while the expression of TRF2 and the tumor suppressor gene p16 was significantly higher in the KTX recipients when compared to the controls. TRF2 and TIN2 correlated significantly with hsCRP; additionally, TRF2 showed significant correlation with plasma creatinine and eGFR. KTx recipients have near to normal telomere length, but they have significantly higher gene expression levels of telomere regulatory proteins compared with healthy controls, suggesting activation of mechanisms preserving telomere length among KTx recipients. Our results suggest that declined graft function and consequent inflammatory response may have influence on telomerase activity.

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Section: Discussionsupporting

confidence: 47%

Section: Discussionmentioning

confidence: 94%

Telomere length regulators are activated in young men after pediatric kidney transplantation compared to healthy controls and survivors of childhood cancer—A cross‐sectional study

Endén

Tainio

Hou

et al. 2019

Pediatric Transplantation

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“…Во время деления клетки длина теломерных концов хромосом сокращается на 30-200 пар оснований [10]. При укорочении хромосом до определенного размера индуцируются процессы клеточного старения [11]. Различные заболевания невоспалительного генеза сопровождаются укорочением длины теломерных повторов хромосом [12].…”

Section: Discussionunclassified

“…ДНК из цельной крови выделяли с использованием набора для выделения ДНК ДНК-Экстран-1 (ЗАО «Синтол» Россия). Длину теломерных повторов хромосом определяли методом количественной полимеразно-цепной реакции в реальном времени [11]. Амплификацию в реальном времени проводили на анализаторе нуклеиновых кислот BIO-RAD CFX 96 Real-Time System (Syngapore).…”

Section: материал и методыunclassified

Effect of chemotherapy on the length of telomeres in patients with breast cancer suffering from arterial hypertension

Doroshchuk¹,

Doroshchuk²,

Vitsenya³

et al. 2018

Kardio. vestn.

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Рак молочной железы (РМЖ)-одно из самых распространенных злокачественных заболеваний у женщин. Противоопухолевая терапия вызывает укорочение теломеров. Малоизученными остаются вопросы влияния противоопухолевой терапии на длину теломеров у женщин с различными молекулярными типами РМЖ и артериальной гипертонией (АГ). Цель исследования-изучить влияние противоопухолевой терапии на длину теломеров у женщин с различными молекулярными типами РМЖ и АГ. Материал и методы. В исследование включали женщин с различными молекулярными типами РМЖ. Всем больным проведено общеклиническое обследование. Группу сравнения составили практически здоровые женщины. Длину теломерных повторов хромосом определяли методом количественной полимеразно-цепной реакции в реальном времени до и после химиотерпаии. Результаты. Длина теломерных повторов хромосом у женщин с РМЖ была достоверно снижена (р<0,05) до начала лечения. За время химиотерапии у женщин с наличием АГ достоверно уменьшилась длина теломеров: на 16,2±4,5% (р<0,05)у пациенток с HER2+ РМЖ и на 12,4±3,8% (р<0,05)-с тройным негативным РМЖ. У женщин с нормальным уровнем артериального давления достоверного уменьшения длины теломеров не отмечено (р=0,22). Заключение. Противоопухолевая терапия вызывает укорочение длины теломеров у женщин с различными молекулярными типами РМЖ с наличием АГ, что может провоцировать развитие и усугубление сердечно-сосудистых заболеваний. Ключевые слова: рак молочной железы, артериальная гипертензия, укорочение теломеров.

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“…(28,29,30) Several specific proteins are related to telomeric DNA, some of those are telomerase and the telomeric repeat binding factors (TRF)1 and TRF2 which directly bind to the TTAGGG repeat and interact with other factors composing large protein complexes regulating TL and structure. (31) TL is greatly variable among individuals with the same age.…”

Section: Telomeres and Telomerasementioning

confidence: 99%

Telomeres and Telomerase in The Aging Heart

2017

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B ACKGROUND:Aging per se is a risk factor for reduced cardiac function and heart diseases, even when adjusted for aging-associated cardiovascular risk factors. Accordingly, aging-related biochemical and cell-biological changes lead to pathophysiological conditions, especially reduced heart function and heart disease. CONTENT:Telomere dysfunction induces a profound p53-dependent repression of the master regulators of mitochondrial biogenesis and function, peroxisome proliferator-activated receptor gamma coactivator (PGC)-1a and PGC-1b in the heart, which leads to bioenergetic compromise due to impaired oxidative phosphorylation and ATP generation. This telomere-p53-PGC mitochondrial/ metabolic axis integrates many factors linked to heart aging including increased DNA damage, p53 activation, mitochondrial, and metabolic dysfunction and provides a molecular basis of how dysfunctional telomeres can compromise cardiomyocytes and stem cell compartments in the heart to precipitate cardiac aging. SUMMARY:The aging myocardium with telomere shortening and accumulation of senescent cells restricts the tissue regenerative ability, which contributes to systolic or diastolic heart failure. Moreover, patients with ion-channel defects might have genetic imbalance caused by oxidative stress-related accelerated telomere shortening, which may subsequently cause sudden cardiac death. Telomere length can serve as a marker for the biological status of previous cell divisions and DNA damage with inflammation and oxidative stress. It can be integrated into current risk prediction and stratification models for cardiovascular diseases and can be used in precise personalized treatments. KEYWORDS: aging, telomere, telomerase, aging heart, mitochondria, cardiac stem cell Indones Biomed J. 2017; 9(3): 129-42 Abstract Introduction

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Telomeres in health and disease

Cited by 28 publications

References 15 publications

Telomere length regulators are activated in young men after pediatric kidney transplantation compared to healthy controls and survivors of childhood cancer—A cross‐sectional study

Telomere length regulators are activated in young men after pediatric kidney transplantation compared to healthy controls and survivors of childhood cancer—A cross‐sectional study

Effect of chemotherapy on the length of telomeres in patients with breast cancer suffering from arterial hypertension

Telomeres and Telomerase in The Aging Heart

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