Temazepam as a hypnotic in osteoarthritic patients

Abstract

PThe effects of nocturnal temazepam elixir on 14 male osteoarthritic patients and 16 age-and sex-matched healthy controls were investigated in a double-blind parallel groups study. Temazepam produced a number of significant changes in objective sleep. In the osteoarthritic patients temazepam reduced the duration of awakenings, percentage stage 0, percentage stage 1, percentage stages (0+1) and increased percentage stage 2 and REM latency. In the controls temazepam reduced the duration of awakenings, percentage stage 0, percentage stages (0+1) and increased percentage stage 2, sleep efficiency and REM latency. During the drug period, seven out of 15 subjects receiving temazepam reported improved sleep, compared with one out of 15 placebo subjects. There was no evidence to suggest that temazepam caused any unwanted side-effects or affected the duration of morning stiffness in osteoarthritic patients. Temazepam produced no significant impairment of early morning psychomotor performance or significant withdrawal effects in either patients or controls.

Subjective assessment of the effects of CNS‐active drugs on sleep by the Leeds sleep evaluation questionnaire: a review

“…Warburton and Wesnes (1984) similarly stated: 'ideally a hypnotic should induce sleep which leaves the patient refreshed and alert the next morning'. The new non-benzodiazepine hypnotics have short half-life and seem to lead to night-time sedation without a decrement in the level of morning alertness and vitality (Hindmarch, 1977) Zopiclone 7.5 mg Improved 6.9 mm ( p < 0.05) (Hindmarch, 1977) Improved, scale not comparable p < 0.05 (Elie and Deschenes, 1983) Zolpidem 10 mg Not significant Not significant Roth et al, 1995) Temazepam 15 mg Not significant (Leigh et al, 1987) Not significant (Leigh et al, 1987) Lorazepam 1 mg Impairment Impairment of serial subtraction, p < 0.01 letter cancellation, car driving scores ) Clobazam 10 mg Not significant Not significant (Hindmarch, 1977) 1990) p < 0.01 Zopiclone 7.5 mg Improved 17.7 mm ( p < 0.05) (Hindmarch, 1990) Improved, scale not comparable p < 0.05 (Elie and Deschenes, 1983) (Bensimon et al, 1990). The LSEQ, consistently with these findings, indicated an improvement in GTS and QOS (ease of getting to sleep and more restful sleep with less awakenings) with Zolpidem 10 mg compared with placebo and there was no significant deterioration in AFS and BFW (study 15 Table 1) showing that Zolpidem did not differ from placebo in subjective feelings of the ease of awakening from sleep or the sense of psychomotor coordination after arising.…”