Temozolomide for Paediatric High-Grade Glioma: Time for a Rethink?

Abstract

Paediatric high-grade gliomas are an almost universally fatal form of childhood cancer. While radiotherapy combined with temozolomide has had a pivotal role in the standard care of adult high-grade gliomas, this has not translated to the paediatric population, where its precise role remains undefined. The effectiveness of this treatment approach and continued use in paediatric high-grade glioma (including diffuse midline glioma) is questionable and we argue that it's time for paediatric neuro-oncologists to consider alternative approaches.