Temperature and density evolution during compaction of a capsule shaped tablet

Numerical evaluation of the capping tendency of microcrystalline cellulose tablets during a diametrical compression test

“…Prior studies measuring the MCC tablet density distribution in a single-radius tablet were conducted using X-ray computed tomography Klinzing et al, 2010) and NMR imaging (Djemai and Sinka, 2006); both density measurements clearly presented high density regions located at the upper edge of the tablet and low density regions located in the middle of the tablet, which agree well with our results (Fig. 9(b)).…”

“…Although pharmaceutical powders in the tablet are not a continuous medium at the particle level, the useful information, such as distributions of density, stress and strain, can be obtained when the powder is small and dense enough. The Drucker-Prager Cap model (DPC model), which considers shear failure and the plastic yielding, has been used as a constitutive model of FEM to determine the local mechanical properties of pharmaceutical powder during powder compactions (Michrafy et al, 2002;Sinka et al, 2003;Cunningham et al, 2004;Wu et al, 2005Wu et al, , 2008Han et al, 2008;Klinzing et al, 2010;Sinha et al, 2010aSinha et al, , 2010bDiarra et al, 2013;Hayashi et al, 2013;Kadiri and Michrafy, 2013). Using the FEM, Michrafy et al (2002) simulated the relative density distribution and the stress distribution within a lactose tablet.…”

Compaction analysis and optimisation of convex-faced pharmaceutical tablets using numerical techniques

“…However, numerical computational modelling tools, such as Finite Element Method (FEM), are very useful techniques providing access to unique results that cannot readily be attained from experimental tests. Recently, modelling techniques were successfully implemented to attain a better insight on the various aspects of the tabletting process such as tablet failure mechanism [6], [7], [8], [9], [10], temperature evolution during the process [8], [11], stress and density distributions within the tablet [12], effect of punch shape [6], [13], and effect of friction [14].…”

Combination of finite element method and Drucker‐Prager Cap material model for simulation of pharmaceutical tableting process

“…All of these models were originally adopted from soil mechanics and were utilized to simulate the die compaction of metallic, ceramic and recently pharmaceutical powders [8][9][10]. However, the Drucker-Prager Cap model was the most used model in modelling of the pharmaceutical tablet and due to its capability of representing the various phenomena associated with compaction such as shear flow, densification and hardening [5,[11][12][13][14].…”

“…* Investigate the effect of punch shape and optimize the compaction tools [15][16]. * Explore the tablet failure mechanism and assess the origin of defect or crack formation [1,12,15,[17][18][19]. * Estimate the break force of the tablet which can replace the empirical methods currently used in design and development process of pharmaceutical product [20].…”