Temperature- and pH-responsive chitosan-based injectable hydrogels for bone tissue engineering

Lavanya, K.; Chandran, S. Viji; Balagangadharan, K.; Selvamurugan, N.

doi:10.1016/j.msec.2020.110862

Cited by 169 publications

(106 citation statements)

References 151 publications

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“…Especially, CS-based injectable hydrogels can be actuated by physical or chemical stimuli via the sol-gel transition. Besides, CS-based injectable hydrogels can deliver cells, drugs and other bioactive molecules, and thus receiving an amount of recognition in fields of cosmetics, food, drug/gene delivery and bone regeneration ( Figure 1B; Zheng et al, 2010;Vo et al, 2016;Menon et al, 2018;Yang et al, 2018;Lavanya et al, 2020).…”

Section: Cs-based Hydrogelsmentioning

confidence: 99%

Recent Advances of Chitosan-Based Injectable Hydrogels for Bone and Dental Tissue Regeneration

Tang

Tan

Zeng

et al. 2020

Front. Bioeng. Biotechnol.

114

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Traditional strategies of bone repair include autografts, allografts and surgical reconstructions, but they may bring about potential hazard of donor site morbidity, rejection, risk of disease transmission and repetitive surgery. Bone tissue engineering (BTE) is a multidisciplinary field that offers promising substitutes in biopharmaceutical applications, and chitosan (CS)-based bone reconstructions can be a potential candidate in regenerative tissue fields owing to its low immunogenicity, biodegradability, bioresorbable features, low-cost and economic nature. Formulations of CS-based injectable hydrogels with thermo/pH-response are advantageous in terms of their highwater imbibing capability, minimal invasiveness, porous networks, and ability to mold perfectly into an irregular defect. Additionally, CS combined with other naturally-derived or synthetic polymers and bioactive agents has proven to be an effective alternative to autologous bone and dental grafts. In this review, we will highlight the current progress in the development of preparation methods, physicochemical properties and applications of CS-based injectable hydrogels and their perspectives in bone and dental regeneration. We believe this review is intended as starting point and inspiration for future research effort to develop the next generation of tissue-engineering scaffold materials.

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Section: Cs-based Hydrogelsmentioning

confidence: 99%

Recent Advances of Chitosan-Based Injectable Hydrogels for Bone and Dental Tissue Regeneration

Tang

Tan

Zeng

et al. 2020

Front. Bioeng. Biotechnol.

114

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“…Another one is examining various gadgets in particular pathways; an obvious illustration is the duplication of various vascular designs to examine the usefulness of a cardiovascular process utilized to deal with peripheral and cardiac artery illness. Enhancing healthcare education [ 26 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ] is another 3D printing application, as certain 3D-printed patient types have shown that they might improve functionality and promote quick learning. The affected person education can be mentioned as another applicable advantage of these methods as patient-based care creates individual education among the major concerns for nearly all health-related suppliers.…”

Section: Introductionmentioning

confidence: 99%

“…Many studies have been performed to review the potential of CS and its derivatives for medical applications [ 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ], but it is worth mentioning here that one of the most prominent differences between the present review and the others is that CS constructs created via 3D printing methods are reviewed specifically. In addition, for first time recent developments of methodology and the capabilities of 3D printing CS-based polymer are highlighted.…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional Printing Constructs Based on the Chitosan for Tissue Regeneration: State of the Art, Developing Directions and Prospect Trends

et al. 2020

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Chitosan (CS) has gained particular attention in biomedical applications due to its biocompatibility, antibacterial feature, and biodegradability. Hence, many studies have focused on the manufacturing of CS films, scaffolds, particulate, and inks via different production methods. Nowadays, with the possibility of the precise adjustment of porosity size and shape, fiber size, suitable interconnectivity of pores, and creation of patient-specific constructs, 3D printing has overcome the limitations of many traditional manufacturing methods. Therefore, the fabrication of 3D printed CS scaffolds can lead to promising advances in tissue engineering and regenerative medicine. A review of additive manufacturing types, CS-based printed constructs, their usages as biomaterials, advantages, and drawbacks can open doors to optimize CS-based constructions for biomedical applications. The latest technological issues and upcoming capabilities of 3D printing with CS-based biopolymers for different applications are also discussed. This review article will act as a roadmap aiming to investigate chitosan as a new feedstock concerning various 3D printing approaches which may be employed in biomedical fields. In fact, the combination of 3D printing and CS-based biopolymers is extremely appealing particularly with regard to certain clinical purposes. Complications of 3D printing coupled with the challenges associated with materials should be recognized to help make this method feasible for wider clinical requirements. This strategy is currently gaining substantial attention in terms of several industrial biomedical products. In this review, the key 3D printing approaches along with revealing historical background are initially presented, and ultimately, the applications of different 3D printing techniques for fabricating chitosan constructs will be discussed. The recognition of essential complications and technical problems related to numerous 3D printing techniques and CS-based biopolymer choices according to clinical requirements is crucial. A comprehensive investigation will be required to encounter those challenges and to completely understand the possibilities of 3D printing in the foreseeable future.

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“…xenografts, allografts and autograft [7][8][9]. Good postoperative outcomes achieved by these surgery methods.…”

Section: Introductionmentioning

confidence: 99%

Ursolic acid loaded-mesoporous hydroxylapatite/ chitosan therapeutic scaffolds promote the bone regeneration

Yu¹,

Wang²,

Liu³

et al. 2020

Preprint

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Background: Mesoporous hydroxylapatite (MHAP) could play an important role in bone regeneration, and UA (Ursolic acid) also promote the osteogenic differentiation. Accordingly, we developed the UA loaded MHAP scaffolds to cure bone defects. In vitro, we synthesize biomaterial scaffolds. By SEM, XRD, EDS and FTIR, we test the performance of the hybrid scaffolds. By drug release, ALP staining, Alizarin red staining, and Western blotting, we test the osteo-inductive properties of scaffold materials. In vivo, We verify bone regeneration through a rat skull defect model.Results: The MHAP is a rod-shaped structure with a length of 100~300nm and a diameter of 40~60nm. The critical structure gives the micro scaffold a property of control release due to the pore sizes of 1.6~4.3 nm in hydroxyapatite and the hydrogen bonding between the scaffolds and UA drugs. The released UA drugs could notably promote the expression of osteogenic-related genes (COL1, ALP, OPG) and osteogenic-related proteins (BMP-2, RUNX2 and COL1). Both the images of μCT and the results of double fluorochrome labelling demonstrated that therapeutic scaffolds promoted the bone regeneration. We obtained the similar results through immunohistochemistry. Conclusions: The MHAP-CS-UA scaffolds have good osteo-inductivity and bone regeneration. And they will be the novel and promising candidates to cure the bone disease.

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Temperature- and pH-responsive chitosan-based injectable hydrogels for bone tissue engineering

Cited by 169 publications

References 151 publications

Recent Advances of Chitosan-Based Injectable Hydrogels for Bone and Dental Tissue Regeneration

Recent Advances of Chitosan-Based Injectable Hydrogels for Bone and Dental Tissue Regeneration

Three-Dimensional Printing Constructs Based on the Chitosan for Tissue Regeneration: State of the Art, Developing Directions and Prospect Trends

Ursolic acid loaded-mesoporous hydroxylapatite/ chitosan therapeutic scaffolds promote the bone regeneration

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