Temperature and Preeclampsia: Is the Association Valid?

Basu, Rupa

doi:10.1111/ppe.12365

Cited by 4 publications

(8 citation statements)

References 9 publications

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“…First, the study captured the associations with temperature during only a 4-week exposure period after conception and before admission. Because the temperature exposure period critical for increasing the risks of HDPs is unclear, multiple lag times and long temperature exposure periods may be necessary 23 . Second, it has been reported that prenatal exposure to air pollution increases gestational hypertension and preeclampsia risks 25,26 .…”

Section: Discussionmentioning

confidence: 99%

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Association between ambient temperature and hypertensive disorders in pregnancy in China

Xiong

Chen

et al. 2020

Nat Commun

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Hypertensive disorders in pregnancy (HDPs) are leading perinatal diseases. Using a national cohort of 2,043,182 pregnant women in China, we evaluated the association between ambient temperatures and HDP subgroups, including preeclampsia or eclampsia, gestational hypertension, and superimposed preeclampsia. Under extreme temperatures, very cold exposure during preconception (12 weeks) increases odds of preeclampsia or eclampsia and gestational hypertension. Compared to preconception, in the first half of pregnancy, the impact of temperature on preeclampsia or eclampsia and gestational hypertension is opposite. Cold exposure decreases the odds, whereas hot exposure increases the odds. Under average temperatures, a temperature increase during preconception decreases the risk of preeclampsia or eclampsia and gestational hypertension. However, in the first half of pregnancy, temperature is positively associated with a higher risk. No significant association is observed between temperature and superimposed preeclampsia. Here we report a close relationship exists between ambient temperature and preeclampsia or eclampsia and gestational hypertension.

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Section: Discussionmentioning

confidence: 99%

“…Recently, a pilot study reported an association between the ambient temperature and preeclampsia (a subtype of HDP) 22 . However, the validity of these results is questionable because of potential bias in the analyses 23 . Our primary aim is to investigate the associations between HDPs and ambient temperatures.…”

mentioning

confidence: 91%

Association between ambient temperature and hypertensive disorders in pregnancy in China

Xiong

Chen

et al. 2020

Nat Commun

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“…Accumulating evidence suggested that environmental factors may play a role in the pathophysiology of preeclampsia [7][8][9][10][11][12][13]. Indeed, preeclampsia was more likely to occur among women who conceived during the warmer period of the year and delivered during the colder months [11,[14][15][16][17]. Because few studies assessed the association between ambient temperature and preeclampsia, the window period of heat effect remains unclear [17].…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, preeclampsia was more likely to occur among women who conceived during the warmer period of the year and delivered during the colder months [11,[14][15][16][17]. Because few studies assessed the association between ambient temperature and preeclampsia, the window period of heat effect remains unclear [17]. To decrease its impact on the association between temperature and preeclampsia, Auger et al [18] adjusted to seasonality.…”

Section: Introductionmentioning

confidence: 99%

“…To decrease its impact on the association between temperature and preeclampsia, Auger et al [18] adjusted to seasonality. An additional parameter that may affect the association of environmental factors and preeclampsia is socioeconomic status [17] as it reflects among other things the patients' urban/rural lifestyle. The latter group is more exposed to the effect of environmental factors and lacks the weather balancing effect of urban leaving such as air conditioning.…”

Section: Introductionmentioning

confidence: 99%

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Temperature and preeclampsia: Epidemiological evidence that perturbation in maternal heat homeostasis affects pregnancy outcome

et al. 2020

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Introduction This study aims to determine the association between temperature and preeclampsia and whether it is affected by seasonality and rural/urban lifestyle. Methods This cohort study included women who delivered at our medical center from 2004 to 2013 (31,101 women, 64,566 deliveries). Temperature values were obtained from a spatiotemporally resolved estimation model performing predictions at a 1×1km spatial resolution. In "Warm" pregnancies >50% of gestation occurred during the spring-summer period. In cold pregnancies >50% of gestation occurred during the fall and winter. Generalized estimating equation multivariable models were used to estimate the association between temperature and incidence of preeclampsia. Results 1) The incidence of preeclampsia in at least one pregnancy was 7% (2173/64,566); 2) during "warm" pregnancies, an elevation of one IQR of the average temperature in the 1 st or the 3 rd trimesters was associated with an increased risk to develop preeclampsia [patients with Jewish ethnicity: 1 st trimester: relative risk (RR) of 2.38(95%CI 1.50; 3.80), 3 rd trimester 1.94(95%CI 1.34;2.81); Bedouins: 1 st trimester: RR = 2.91(95%CI 1.98;4.28), 3 rd trimester: RR = 2.37(95%CI 1.75;3.20)]; 3) In "cold" pregnancies, an elevation of one IQR of average temperature was associated with a lower risk to develop preeclampsia among patients with

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