Temperature/anion-dependent self-assembly of Co(II) coordination polymers based on a heterotopic imidazole-tetrazole-bifunctional ligand: Structures and magnetic properties

Cai, Song‐Liang; Yu, Hongwei; Gao, Yong; Fan, Jin; Zheng, Sheng‐Run; Zhang, Weiguang

doi:10.1016/j.inoche.2017.06.022

Cited by 6 publications

(1 citation statement)

References 37 publications

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“…ligands is less developed, mainly due to the unpredictable outcome of the architecture due to the less symmetric imidazolebased ligands (45,46). As an important five-membered aromatic heterocycle, imidazole and its derivatives are widely found in both natural and synthetic functional materials (47)(48)(49)(50)(51)(52)(53). The desirable electron-rich characteristics of the imidazole ring make its binding through diverse weak interactions with a variety of enzymes and receptors in biological systems possible (54,55).…”

Section: Significancementioning

confidence: 99%

Self-assembled ruthenium (II) metallacycles and metallacages with imidazole-based ligands and their in vitro anticancer activity

Zhao

Zhang

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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Six tetranuclear rectangular metallacycles were synthesized via the [2+2] coordination-driven self-assembly of imidazole-based ditopic donor 1,4-bis(imidazole-1-yl)benzene and 1,3-bis(imidazol-1-yl)benzene, with dinuclear half-sandwichp-cymene ruthenium(II) acceptors [Ru2(µ-η4-oxalato)(η6-p-cymene)2](SO3CF3)2, [Ru2(µ-η4-2,5-dioxido-1,4-benzoquinonato)(η6-p-cymene)2](SO3CF3)2and [Ru2(µ-η4-5,8-dioxido-1,4-naphtoquinonato)(η6-p-cymene)2](SO3CF3)2, respectively. Likewise, three hexanuclear trigonal prismatic metallacages were prepared via the [2+3] self-assembly of tritopic donor of 1,3,5-tri(1H-imidazol-1-yl)benzene with these ruthenium(II) acceptors respectively. Self-selection of the single symmetrical and stable metallacycle and cage was observed although there is the possibility of forming different conformational isomeric products due to different binding modes of these imidazole-based donors. The self-assembled macrocycles and cage containing the 5,8-dioxido-1,4-naphtoquinonato (donq) spacer exhibited good anticancer activity on all tested cancer cell lines (HCT-116, MDA-MB-231, MCF-7, HeLa, A549, and HepG-2), and showed decreased cytotoxicities in HBE and THLE-2 normal cells. The effect of Ru and imidazole moiety of these assemblies on the anticancer activity was discussed. The study of binding ability of these donq-based Ru assemblies with ctDNA indicated that the complex 9 with 180° linear 1 ligand has the highest bonding constantKbto ctDNA.

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