As an important method for improving the plasticity of titanium alloys, the "hydrogen (H)-induced plasticization" mechanism has been widely studied. The present study comparatively investigates the high-temperature tensile properties, deformation mechanism, and cylindrical drawing properties of hydrogenated and non-hydrogenated Ti-22Al-25Nb alloys. The results indicate that the "H-induced plasticization" effect is the most obvious at 0.2 wt% hydrogenation. At 960 C, the elongation percentage of the 0H alloy is 109% and the elongation percentage of the 0.2H alloy is 202%. Through a cylindrical drawing test, it is found that after hydrogenation, the forming performance of the alloy improved significantly.