Temperature Control Based on a Modified Smith Predictor for Injectable Drug Formulations

Abstract

This paper proposes a modified Smith predictor scheme for temperature control during the formulation of injectable drugs in chemical reactors. The dynamic model of this process is obtained from an identification procedure applied in a real chemical reactor of the pharmaceutical industry. This identification procedure yields a second order with dominant time delay transfer function. A PI controller combined with a modified Smith predictor is therefore designed which behaves robustly against the effect of measured or unmeasured external disturbances. Simulated results compare the performance of the proposed controller with a standard PI controller, also combined with a conventional Smith predictor, and with Astrom modified Smith predictor. Four performance indexes have been used in this comparison: three related to the output performance (settling time, overshooting, and IAE), and a fourth one related to the control effort (EU). The analysis of these indexes shows that the proposed controller provides lower values of the compared indexes.

Modelado y control de temperatura para una clase de sistema derivado de la ley de enfriamiento de Newton

“…En (Benítez et al, 2016), se presenta el control de temperatura bajo ganancias difusas de hornos para el recalentamiento de losas para la industria. En (Benítez et al, 2015), se presenta el control bajo un predictor de Smith donde se controla la temperatura durante la formulación de medicamentos inyectables en reactores químicos. En (Santos et al, 2018), se presenta el control de temperatura de unos paneles solares.…”