Temperature controlled loading and release of curcumin in polyelectrolyte multilayers thin films

Saikaew, Rateeya; Marsal, P.; Grenier, B.; Dubas, Stephan Thierry

doi:10.1016/j.matlet.2017.12.010

Cited by 20 publications

(6 citation statements)

References 22 publications

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“…7 In addition, various PEM fabrication methods exist including dip-coating (the most common), spray-coating, spincoating, dynamic-coating, and electrodeposition. 8 Over the years, PEMs have found interest in fields such as membrane technology, 9 catalysis, 10 semiconductors, 11 drug delivery, 12 and optical devices 13 since layer thickness, affinity, and refractive indices can be controlled. Concerning the field of membranes, the layer-by-layer (LbL) dip-coating approach 14 to preparing PEMs has become widely used to coat a selective layer on the inner surface of hollow fiber support membranes.…”

Section: ■ Introductionmentioning

confidence: 99%

Role of Polycation and Cross-Linking in Polyelectrolyte Multilayer Membranes

Reurink

Willott

Roesink

et al. 2020

ACS Appl. Polym. Mater.

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Alternate deposition of oppositely charged polyelectrolytes is an excellent approach to control the chemistry of interfaces. Membrane technology is one field that benefits from the simplicity and tunability of polyelectrolyte multilayers (PEMs). Herein, ultrafiltration support membranes are coated with PEMs to fabricate nanofiltration membranes. Three PEMs, of different polymeric structures, namely, those of poly(4-styrene sulfonate) (PSS)/poly(allylamine hydrochloric acid) (PAH), PSS/poly(ethyleneimine) (PEI, branched), and PSS/poly(4-aminostyrene) (PAS), are prepared and studied from a fundamental perspective in terms of multilayer composition and cross-linking and also from an applied perspective through PEM membrane performance. The low molecular weight cutoff (MWCO) of the PSS/PAH membranes signifies their dense structure (small mesh size), while ion retentions indicate that the dielectric exclusion mechanism is dominant. The PSS/PEI membranes are even denser and have higher selectivities. In contrast, the PSS/PAS membranes are more open, which is likely due to the lower charge density of PAS compared to PEI and PAH. After chemical cross-linking, all of the PEM membranes are denser and therefore more selective and less permeable to water. Micropollutant retention increases for cross-linked PSS/PAH membranes, whereas little to no improvement is seen for cross-linked PSS/PAS and PSS/PEI membranes. Overall, this study shows that completely different membrane properties can be obtained by changing the type of polycation, thus demonstrating the high versatility of PEM-based membranes. In addition, for all PEM membranes, cross-linking acts as an additional tuning parameter that leads to denser and typically more selective layers.

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Section: ■ Introductionmentioning

confidence: 99%

Role of Polycation and Cross-Linking in Polyelectrolyte Multilayer Membranes

Reurink

Willott

Roesink

et al. 2020

ACS Appl. Polym. Mater.

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“…Layer-by-layer (LbL) assembly has become a useful tool for building up multilayer thin films with controlled thickness and functionality , for a variety of applications, ranging from drug delivery and radical scavenging to photonics . One appeal of the technique is a wide range of molecular interactions and components that can be deployed in film construction.…”

Section: Introductionmentioning

confidence: 99%

Effect of a Competitive Solvent on Binding Enthalpy and Chain Intermixing in Hydrogen-Bonded Layer-by-Layer Films

et al. 2019

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This work is focused on the effect of a smallmolecule/hydrogen-bonding competitor on the heat of complexation of hydrogen-bonding polymers in aqueous solutions, as well as on deposition of these molecules within layer-by-layer (LbL) films. Specifically, binding between poly(methacrylic acid) (PMAA) and poly(vinylpyrrolidone) (PVP) under acidic conditions in the presence of dimethyl sulfoxide (DMSO) has been explored. Isothermal titration calorimetry showed that with increasing concentration of DMSO in aqueous solution, the positive enthalpy of formation of PMAA/PVP complexes decreased and switched sign at ∼25 vol % DMSO. This change is interpreted as a transition from endothermal association between PMAA and PVP in water, driven by release of solvation water molecules, to exothermic association driven by the enthalpy of interpolymer hydrogen bonding. This switch is interpreted as destruction of polymer hydration shells by DMSO molecules. The content of DMSO also strongly impacted the growth of LbL films. With an increase in DMSO concentration from 0 to 60 vol %, polymer mass deposited within the bilayer increased, while larger DMSO concentrations suppressed film deposition. The effect of DMSO was also revealed in neutron reflectometry measurements, which showed enhanced interpenetration of deuterated PMAA chains within a hydrogenated LbL matrix at increasing concentration of DMSO. The dependence of film intermixing on DMSO content was strongly history dependent. While assembly of LbL films in aqueous solutions followed by exposure to a mixed solvent postassembly did not significantly influence the internal film structure, the effect of DMSO on film intermixing was strongest when DMSO was present in the film deposition solutions.

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“…In other studies, due to the low solubility of curcumin in aqueous media, in vitro curcumin release investigations were conducted in PBS (pH 7.4) containing Tween 80 (0.4–0.5% ( wt / v )) and ethanol (10% v / v ) [ 19 , 59 ]. The release of antimicrobial and antioxidant agents was also reported in 90:10 water:ethanol at different temperatures for polyelectrolyte multilayer (PEM) thin films loaded with 5% ( wt / v ) curcumin for transdermal drug delivery applications [ 60 ] and 70% ethanol in the case of clotrimazole-loaded fabric testing [ 61 ]. The sumac release from nanosheets was assessed at neutral (7.4) and acidic (4.5) pH values, simulating different microenvironment conditions in intact and injured skin [ 62 ].…”

Section: Resultsmentioning

confidence: 99%

Donkey Gelatin and Keratin Nanofibers Loaded with Antioxidant Agents for Wound Healing Dressings

Râpă,

Gaidau,

Stefan

et al. 2024

Gels

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Acute and chronic wounds present a significant healthcare challenge, requiring innovative solutions for effective treatment. The exploitation of natural by-products with advanced cell regeneration potential and plant-based materials, which possess bioactive properties, is an innovative topic in wound management. This study investigates the potential of donkey gelatin and keratin for blending with natural bioactive extracts such as sumac, curcumin, and oak acorn to fabricate antioxidant and antimicrobial nanofibers with accelerated wound healing processes. The fabricated nanofibers possess good in vitro biocompatibility, except for the sumac-based donkey nanofibers, where cell viability significantly dropped to 56.25% (p < 0.05 compared to non-treated cells). The nanofiber dimensions showed structural similarities to human extracellular matrix components, providing an ideal microenvironment for tissue regeneration. The donkey nanofiber-based sumac and curcumin extracts presented a higher dissolution in the first 10 min (74% and 72%). Curcumin extract showed similar antimicrobial and antifungal performances to rivanol, while acorn and sumac extracts demonstrated similar values to each other. In vitro tests performed on murine fibroblast cells demonstrated high migration rates of 89% and 85% after 24 h in the case of acorn and curcumin nanofibers, respectively, underscoring the potential of these nanofibers as versatile platforms for advanced wound care applications.

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Temperature controlled loading and release of curcumin in polyelectrolyte multilayers thin films

Cited by 20 publications

References 22 publications

Role of Polycation and Cross-Linking in Polyelectrolyte Multilayer Membranes

Role of Polycation and Cross-Linking in Polyelectrolyte Multilayer Membranes

Effect of a Competitive Solvent on Binding Enthalpy and Chain Intermixing in Hydrogen-Bonded Layer-by-Layer Films

Donkey Gelatin and Keratin Nanofibers Loaded with Antioxidant Agents for Wound Healing Dressings

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