Temperature-Dependant Volumetric and Compressibility Studies of Drug-Surfactant Interactions in Dimethylsulfoxide (DMSO) Solutions

Abstract

In this work we present apparent molar volume, v and apparent molar adiabatic compressibility, values of sodium dodecyl sulphate (SDS) in DMSO and in DMSO solution of 0.25 % w/v 6-methyl-4(2-hydroxy-3-methoxyphenyl)-2-thioxo-1,2,3,4-tetrahydro pyrimidine-5 carboxylic acid ethyl ester (a pyrimidine derivative drug). The study was carried out over a temperature range (20-40 C) covering a wide range of SDS concentration (2-11 mmol dm −3. Being highly sensitive to the extrinsic experimental conditions, a difference observed in the SDS concentration dependence of both v and , values in pure DMSO and in 0.25% w/v DMSO solution of 6-methyl-4(2-hydroxy-3-methoxyphenyl)-2-thioxo-1,2,3,4-tetrahydro pyrimidine-5 carboxylic acid ethyl ester is regarded as being due to the differing extent of SDS-DMSO interactions; the data tend to indicate the existence of relatively strong SDS-drug interactions.

Surfactant–Amino Acid and Surfactant–Surfactant Interactions in Aqueous Medium: a Review

“…As in the case of SDS with Gly, Ala, Val and Leu, it was observed that the increasing hydrophobicity from Gly to Leu, the water clathrate-like structure increased with increasing hydrophobicity of these amino acids (Leu > Val > Ala > Gly) resulting into a decrease in CMC of SDS with increasing hydrophobicity of these amino acids [127]. With cationic surfactant, HTAB, similar trends were observed, a decrease in CMC in the sequence Gly-Gly-Gly < Gly-Gly < Gly was seen.…”

Use of Masson's and Jones–Dole equations to study different types of interactions of three pharmacologically important drugs in ethanol

“…These parameters are calculated from volumetric and viscometric properties of drugs in solutions 6 . This volumetric and viscometric study of different drugs in different solvent systems have been reported in literature for example, M. Shaikh et al reported viscometric and volumetric properties of paracetamol in ethanol water system at various temperatures, 7 temperature dependent volumetric and compressibility studies of drug‐surfactant interaction in DMSO solution by S. Chauhan et al, 8 apparent molar volumes and B ‐coefficient of sodium salicylate in different solvent systems by A. B. Nikumbh and R. C. Bhujbal 9…”

Thermodynamics and Micellar Behavior of Surface-Active Drugs in Aqueous Solution of Electrolytes: Surface Tension Study

“…Micellization process (formation of micelles) can be studied with the help of different physical properties of solution like conductivity, viscosity, surface tension, etc. [4][5][6][7][8][9][10][11].…”