The article considers result of studying the prevalence of diseases of the genitourinary system among residents of the Chechen Republic, a comparative analysis of the incidence rates in the republic for diseases of the genitourinary system with similar indicators in the Russian Federation and the North Caucasian Federal District is carried out. The aim of the study was to conduct a comparative analysis of the incidence of diseases of the genitourinary system and urolithiasis in residents of the Chechen Republic (CR) with similar rates from all over Russia and the North Caucasian Federal District. Statistical data on the incidence of these nosologies in 2014 and 2015 according to the Federal State Statistics Service across the Russian Federation (RF), in the Chechen Republic, as well as in the North Caucasian Federal District was used as a method of research. Analysis of statistics on the incidence of diseases of the genitourinary system, prevalence of urolithiasis, chronic renal failure in Russia as a whole showed a clear tendency to increase in these indicators over the past decades. Previous studies have found that drinking water obtained from the rivers of the Chechen Republic and its tributaries is one of the main pathways for delivering trace elements, including heavy metal salts, to the body of residents of Chechnya. With this factor in mind, a much worse situation in the Chechen Republic was revealed than across Russia and in the North Caucasian Federal District. As a result of the study, it was found that the overall incidence of genitourinary pathology, chronic renal failure, rates of the newly detected incidence of the genitourinary system, urolithiasis and chronic renal failure during the study period was significantly higher in the Chechen Republic. Although the overall incidence of urolithiasis in the Chechen Republic did not exceed similar rates in Russia and the North Caucasian Federal District, it increased significantly in 2015 in comparison with 2014.