Temperature Dependence of the Solubility of Acetaminophen in Propylene Glycol + Ethanol Mixtures

Thermodynamic study of the solubility of sodium naproxen in some ethanol + water mixtures

“…Besides, temperature-solubility dependence allows us to carry out the respective thermodynamic analysis, which, on the other hand, also permits inside the molecular mechanisms, involved toward the solution processes. 6 The main objective of this study was to evaluate the effect of the cosolvent composition on the solubility and solution thermodynamics of Na-NAP in ethanol (EtOH) + water cosolvent mixtures based on the van't Hoff method as has been done earlier with procaine hydrochloride. 8 Thus, this investigation amply the information reported by Chavez about the solubility of this drug in the same cosolvent system.…”

An Improved Automated Setup for Solubility Determination of Drugs

“…As described in Introduction, there are some practical limitations for the previous setup which overcome in the improved setup. To compare the validity of the measured solubility data using the improved setup, the data was also compared with the corresponding data collected from the literature [10][11][12][13][14][15][16][17][18][19][20][21] and listed in Table 2 The overall IPD reported in Table 2 [25][26][27] The main advantages of the improved setup are; 1) a wider temperature range, 2) suitable for the solubility measurement of a highly low soluble drugs to very soluble drugs, 3) very similar measured solubilities to those determined using the common shake-flask method, 4) no need for chromophor groups on the drug molecule, 5) more repeatable results when compared with a previously reported setup, and 6) affecting parameters, such as stirrer rate, required time for equilibration, etc., could be adjusted by the user.…”

Acetaminophen, Methocarbamol, Guaifenesin and Mephenesin in Propylene Glycol: Solubility and Phase Behaviour for Use in Medical Industry

“…Unfortunately, experimental values of μ0 are not available for neat drugs and the values estimated using density functional theory (DFT) are found to be very unreliable for the purpose of calculations, as discussed in our previous publication [15]. However, it is interesting to note that the discomfort experienced by patients, administrated with the liquid drugs intravenously where PG is treated as excipient [2,[6][7][8][9], may be due to the above-observed * T0 values have an error of (±) 5% due to the short range of data points. heterogeneity.…”

“…In a few formulations, the maximum amount of PG is reported to be up to 55% by weight in oral solutions and nearly 80% in injectable formulation [2,6]. Common medicines used as drug solution with PG are acetaminophen, methocarbamol, guaifenesin, amprenavir, oxytetracycline, pentobarbital sodium, etomidate, lormetazepam, lorazepam, cotrimoxazole, amoxicillin, omeprazole, temazepam, etc., where PG is treated as excipient [2,[6][7][8][9]. For orally administered drugs solubility is the most important parameter.…”

“…Therefore, solubility behavior of drugs in PG is useful for pharmaceutical dose design. There are many methods in use to study the solubility [5,[7][8][9]17] but these methods do not explain the exact phase behavior of the mixtures. For these reasons, it is important to determine the complete information about physicochemical data of pharmaceutical systems.…”