This study compares experimentally determined and simulated mechanical strength of different geometries laser cut into alumina ceramic substrates. A digital power modulated 500 W single mode fiber laser is used to cut differently shaped inner contours into rectangular ceramic substrates. The flexural strength of these samples is measured by a 3-point-bending test. In addition, employing a finite element simulation the principal stress of these geometries during a 3-point-bending is simulated with a linear elastic model. The reciprocal of the simulated stress is compared with the measured strength revealing an excellent agreement. We, therefore, can conclude that the strength reduction by cutting inner contours can be exclusively explained by the geometry of the rectangular, which in turn implies that the fiber laser cutting process itself causes no relevant additional structural damage. These results highlight the superior quality of digital power modulated fiber laser cutting of ceramics. Moreover, we demonstrate by a further comparison between experimental and simulated results that an increased strength is feasible by displacing fragile parts of inner contours to areas with less mechanical load.