Temperature distribution as function of time around a small spherical heat source of local magnetic hyperthermia

Andrä, W.; D'ambly, C.‐G.; Hergt, R.; Hilger, Ingrid; Kaiser, Werner A.

doi:10.1016/s0304-8853(98)00552-6

Cited by 200 publications

(107 citation statements)

References 10 publications

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“…Установившиеся конвективные течения, возни-кающие под действием компактных источников тепла, активно исследуются на протяжении по-следних двух десятилетий [1][2][3][4][5][6][7][8][9]. Первоначально задача носила преимущественно фундаментальный характер.…”

Section: Introductionunclassified

Weight Loss on Heating of the Body in Various Liquids

Burkova¹,

Kondrashov²,

Rybkin³

et al. 2017

Вестник ПГУ. Физика

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Section: Introductionunclassified

Weight Loss on Heating of the Body in Various Liquids

Burkova¹,

Kondrashov²,

Rybkin³

et al. 2017

Вестник ПГУ. Физика

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“…To consider the tumor, it is not necessary to use finite element method despite the significant dependence of thermal conductivity on the organ type (typically, 0.003-0.006 WK −1 cm −1 [14]) because a feature of this therapy includes treatments of small unidentifiable metastatic cancers with an approximate diameter of 1 cm, within which thermal properties are assumed homogeneous. According to Andrä et al [15], the heat at 2 Δ is roughly dissipated by conduction when such a tumor is steadily maintained at a temperature that exceeds the temperature of the surrounding area by Δ . Conversely, the blood flow in tumor tissues transfers heat at the rate ( 3 /6) Δ , where denotes the blood specific heat and approximately corresponds to 4 JK −1 cm −3 , while corresponds to the tumor tissue blood perfusion rate and it varies based on the type, phase, size, and temperature of the tumor.…”

Section: Thermal Models Of Tumor and Hot Spot Portionmentioning

confidence: 99%

Practical Solution for Effective Whole-Body Magnetic Fluid Hyperthermia Treatment

Mamiya

Takeda

Naka

et al. 2017

Journal of Nanomaterials

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Magnetic fluid hyperthermia therapy is considered as a promising treatment for cancers including unidentifiable metastatic cancers that are scattered across the whole body. However, a recent study on heat transfer simulated on a human body model showed a serious side effect: occurrences of hot spots in normal tissues due to eddy current loss induced by variation in the irradiated magnetic field. The indicated allowable upper limit of field amplitude ac for constant irradiation over the entire human body corresponded to approximately 100 Oe at a frequency of 25 kHz. The limit corresponds to the value ac of 2.5 × 10 6 Oe⋅s −1 and is significantly lower than the conventionally accepted criteria of 6 × 10 7 Oe⋅s −1 . The present study involved evaluating maximum performance of conventional magnetic fluid hyperthermia cancer therapy below the afore-mentioned limit, and this was followed by discussing alternative methods not bound by standard frameworks by considering steady heat flow from equilibrium responses of stable nanoparticles. Consequently, the clarified potentials of quasi-stable core-shell nanoparticles, dynamic alignment of easy axes, and short pulse irradiation indicate that the whole-body magnetic fluid hyperthermia treatment is still a possible candidate for future cancer therapy.

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“…Thus, if an additional substance is injected into the tissue, these parameters change and the model of the mixture has to be developed [29]:…”

Section: Model Parametersmentioning

confidence: 99%

A Thermofluid Analysis of the Magnetic Nanoparticles Enhanced Heating Effects in Tissues Embedded with Large Blood Vessel during Magnetic Fluid Hyperthermia

Adhikary

Banerjee

2016

Journal of Nanoparticles

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The thermal effect developed due to the heating of magnetic nanoparticles (MNPs) in presence of external magnetic field can be precisely controlled by the proper selection of magnetic absorption properties of the MNPs. The present paper deals with the numerical simulation of temperature field developed within or outside the tumor, in the presence of an external alternating magnetic field, using a thermofluidic model developed using ANSYS FLUENT5. A three-layer nonuniform tissue structure with one or two blood vessels surrounding the tumor is considered for the present simulation. The results obtained clearly suggest that the volumetric distribution pattern of MNPs within the tumor has a strong influence on the temperature field developed. The linear pattern of volumetric distribution has a strong effect over the two other types of distribution considered herein. Various other important factors like external magnetic field intensity, frequency, vascular congestion, types of MNP material, and so forth are considered to find the influence on the temperature within the tumor. Results show that proper selection of these parameters has a strong influence on the desired therapeutic temperature range and thus it is of utmost importance from the efficacy point of view of magnetic fluid hyperthermia (MFH).

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Temperature distribution as function of time around a small spherical heat source of local magnetic hyperthermia

Cited by 200 publications

References 10 publications

Weight Loss on Heating of the Body in Various Liquids

Weight Loss on Heating of the Body in Various Liquids

Practical Solution for Effective Whole-Body Magnetic Fluid Hyperthermia Treatment

A Thermofluid Analysis of the Magnetic Nanoparticles Enhanced Heating Effects in Tissues Embedded with Large Blood Vessel during Magnetic Fluid Hyperthermia

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