This paper presents an application-specific integrated circuit (ASIC) aimed for an alternative design of a digital 3-D magnetometer for space applications, with a significant reduction in mass and volume while maintaining a high sensitivity. The proposed system uses magnetic field sensors based on anisotropic magnetoresistances and a rad-hard mixed-signal ASIC designed in a standard 0.35 µm CMOS technology. The ASIC performs sensor-signal conditioning and analogue-to-digital conversion, and handles calibration tasks, system configuration, and communication with the outside. The proposed system provides high sensitivity to low magnetic fields, down to 3 nT, while offering a small and reliable solution under extreme environmental conditions in terms of radiation and temperature.Index Terms-Aerospace electronics, anisotropic magnetoresistance (AMR), CMOS mixed-signal application-specific integrated circuit (ASIC), magnetometer, radiation hardened by design (RHBD).