Temperature effect on CuO nanoparticles: Antimicrobial activity towards bacterial strains

George, Amal; Raj, D. Magimai Antoni; Raj, A. Dhayal; Irudayaraj, A. Albert; Arumugam, J.; Kumar, Manoj; Prabu, H. Joy; Sundaram, S. John; Al-Dhabi, Naïf Abdullah; Arasu, Mariadhas Valan; Mâaza, M.; Kaviyarasu, K.

doi:10.1016/j.surfin.2020.100761

Cited by 39 publications

(16 citation statements)

References 29 publications

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“…This reduction in the size of E3 nanoparticles compared to E2 and E1 nanoparticles can be attributed to the more evaporation of water and subsequent aggregation of particles at 350 o C as evident from FTIR results where the water absorbance band in the case of E3 nanoparticles is less deeper as compared to water absorbance band in T, E1 and E2 particles. Similar results were observed by George et al (2020) where they found that at the maximum calcination temperatures the size of nanoparticles decreased. The other reason behind this may be the inherent properties of the nanoparticles, in which particles always tend to acquire stable shape and size at particular conditions as reported by Malviya et al (2015).…”

Section: Discussionsupporting

confidence: 87%

Effects of differently incubated cupric oxide nanoparticles on the granulosa cells of caprine ovary in vitro

Kumar

Sharma

2022

Environ Sci Pollut Res

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Present study was aimed to investigate the effect of temperature on the shape and size of nanoparticles and related cytotoxicity of these particles on ovarian granulosa cells. Cupric oxide nanoparticles (CuONPs) were synthesized using a simple, e cient, and reproducible precipitation method involving reduction of Cu metal salt with sodium hydroxide and then incubation of the precipitates at 70 o C for 5 hrs. Subsequently, this prepared sample was divided into 3 subsamples and incubated at 3 different temperatures i.e. 70 o C, 150 o C, and 350 o C for a time duration of 5 hrs. to study the effect of temperature on the particles. The products were characterized by XRD, FTIR, HRTEM, and FESEM. Characterization of the particles revealed that all particles were monoclinic crystalline in nature and had a size range from 9 nm -60 nm. Particles were of different shapes; spherical, needle, and capsule. Toxicity of each particle was determined on granulosa cells by exposing them for 24 hrs. at 2 different doses. Toxicological results showed the size and shape-related toxicity of nanoparticles; particles which were spherical shape were signi cantly more toxic than capsule-shaped particles.

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Section: Discussionsupporting

confidence: 87%

Effects of differently incubated cupric oxide nanoparticles on the granulosa cells of caprine ovary in vitro

Kumar

Sharma

2022

Environ Sci Pollut Res

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“…The cell wall structure of E. coli is more complex than that of S. aureus [ 56 ], and thus Cu 2+ , Mg 2+ , and Zn 2+ ions can barely disrupt the cell wall of E. coli and hardly exert a bacteriostatic effect [ 57 , 58 ]. In addition, nanoapatites with low concentrations of Cu 2+ ions exhibited better bacteriostatic effects than those with Mg 2+ and Zn 2+ [ 59 ].…”

Section: Resultsmentioning

confidence: 99%

Morphological Changes, Antibacterial Activity, and Cytotoxicity Characterization of Hydrothermally Synthesized Metal Ions-Incorporated Nanoapatites for Biomedical Application

et al. 2022

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The objective of this study was to prepare hydroxyapatite (HA) with potential antibacterial activity against gram-negative and gram-positive bacteria by incorporating different atomic ratios of Cu2+ (0.1–1.0%), Mg2+ (1.0–7.0%), and Zn2+ (1.0–7.0%) to theoretically replace Ca2+ ions during the hydrothermal synthesis of grown precipitated HA nanorods. This study highlights the role of comparing different metal ions on synthetic nanoapatite in regulating the antibacterial properties and toxicity. The comparisons between infrared spectra and between diffractograms have confirmed that metal ions do not affect the formation of HA phases. The results show that after doped Cu2+, Mg2+, and Zn2+ ions replace Ca2+, the ionic radius is almost the same, but significantly smaller than that of the original Ca2+ ions, and the substitution effect causes the lattice distance to change, resulting in crystal structure distortion and reducing crystallinity. The reduction in the length of the nanopatites after the incorporation of Cu2+, Mg2+, and Zn2+ ions confirmed that the metal ions were mainly substituted during the growth of the rod-shape nanoapatite Ca2+ distributed along the longitudinal site. The antibacterial results show that nanoapatite containing Cu2+ (0.1%), Mg2+ (3%), and Zn2+ (5–7%) has obvious and higher antibacterial activity against gram-positive bacteria Staphylococcus aureus within 2 days. The antibacterial effect against the gram-negative bacillus Escherichia coli is not as pronounced as against Staphylococcus aureus. The antibacterial effect of Cu2+ substituted Ca2+ with an atomic ratio of 0.1~1.0% is even better than that of Mg2+- and Zn2+- doped with 1~7% groups. In terms of cytotoxicity, nanoapatites with Cu2+ (~0.2%) exhibit cytotoxicity, whereas Mg2+- (1–5%) and Zn2+- (~1%) doped nanoapatites are biocompatible at low concentrations but become cytotoxic as ionic concentration increases. The results show that the hydrothermally synthesized nanoapatite combined with Cu2+ (0.2%), Mg2+ (3%), and Zn2+ (3%) exhibits low toxicity and high antibacterial activity, which provides a good prospect for bypassing antibiotics for future biomedical applications.

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“… 69 Essentially, the antibacterial activities of copper are known to be more efficient in high temperatures and high relative humidity within hours. 31 , 34 In one study viable endospores in Clostridium difficile spp. were completely inactivated within 24 h to 48 h on a copper surface.…”

Section: Hydroxyapatite Scaffold Containing Nanomaterials As Implant Materials In Bone Tissue Engineering: Anti-bacterial In Vitro and Inmentioning

confidence: 99%

Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery

Halim¹,

Hussein²,

Kandar

2021

IJN

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Hydroxyapatite is a basic mineral that is very important to the human body framework. Recently, synthetic hydroxyapatite (SHA) and its nanocomposites (HANs) are the subject of intense research for bone tissue engineering and drug loading system applications, due to their unique, tailor-made characteristics, as well as their similarities with the bone mineral component in the human body. Although hydroxyapatite has good biocompatibility and osteoconductive characteristics, the poor mechanical strength restricts its use in non-load-bearing applications. Consequently, a rapid increase in reinforcing of other nanomaterials into hydroxyapatite for the formation of HANs could improve the mechanical properties. Most of the research reported on the success of other nanomaterials such as metals, ceramics and natural/synthetic polymers as additions into hydroxyapatite is reviewed. In addition, this review also focuses on the addition of various substances into hydroxyapatite for the formation of various HANs and at the same time to try to minimize the limitations so that various bone tissue engineering and drug loading system applications can be exploited.

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Temperature effect on CuO nanoparticles: Antimicrobial activity towards bacterial strains

Cited by 39 publications

References 29 publications

Effects of differently incubated cupric oxide nanoparticles on the granulosa cells of caprine ovary in vitro

Effects of differently incubated cupric oxide nanoparticles on the granulosa cells of caprine ovary in vitro

Morphological Changes, Antibacterial Activity, and Cytotoxicity Characterization of Hydrothermally Synthesized Metal Ions-Incorporated Nanoapatites for Biomedical Application

Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery

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