Temperature Gradient Interaction Chromatography: A Perspective

Pagliarulo, Antonella

doi:10.1007/s10337-021-04068-1

Cited by 7 publications

(2 citation statements)

References 45 publications

(49 reference statements)

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“…Repeated chemotherapeutic therapy has led to tumors resistant to these agents, which is now one of the leading causes of cancer [ 79 ]. As a result, identifying natural compounds that target and multiply signaling pathways, as well as growth inhibition, is highly beneficial [ 80 ]. Without a doubt, cancer treatment necessitates the administration of drugs with low toxicity to surrounding tissues and high therapeutic efficacy.…”

Section: Herbal Drug Formulationsmentioning

confidence: 99%

Modern Herbal Nanogels: Formulation, Delivery Methods, and Applications

Sindhu

Gupta

Wadhera

et al. 2022

Gels

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This study examined the most recent advancements in nanogel production and drug delivery. Phytochemistry is a discipline of chemistry that studies herbal compounds. Herbal substances have aided in the development of innovative remedies for a wide range of illnesses. Several of these compounds are forbidden from being used in medications due to broad medical characteristics and pharmacokinetics. A variety of new technical approaches have been investigated to ameliorate herbal discoveries in the pharmaceutical sector. The article focuses on the historical data for herb-related nanogels that are used to treat a variety of disorders with great patient compliance, delivery rate, and efficacy. Stimulus-responsive nanogels such as temperature responsive and pH-responsive systems are also discussed. Nanogel formulations, which have been hailed as promising targets for drug delivery systems, have the ability to alter the profile of a drug, genotype, protein, peptide, oligosaccharide, or immunogenic substance, as well as its ability to cross biological barriers, biodistribution, and pharmacokinetics, improving efficacy, safety, and patient cooperation.

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Section: Herbal Drug Formulationsmentioning

confidence: 99%

Modern Herbal Nanogels: Formulation, Delivery Methods, and Applications

Sindhu

Gupta

Wadhera

et al. 2022

Gels

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“…One approach to determine polymer end groups is using interac ve polymer chromatography (IPC), in which reten on in IPC is o en dependent on the chemical composi on, func onality, and molecular weight of the polymer [12][13][14][15][16][17][18][19][20][21]. More specifically, interac on gradient polymer elu on chromatography (interac ve GPEC) [17,[22][23][24].…”

mentioning

confidence: 99%

Functionality-type and chemical-composition separation for poly(lactide-co-glycolide) using gradient elution with basic and acidic additives in normal-phase liquid chromatography

Serizawa,

Reekers,

Delft

et al. 2024

Preprint

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The end groups of poly(lactide-co-glycolide) (PLGA) play a crucial role in determining the properties of polymers used in drug delivery systems. Research has shown that the encapsulation efficiency in PLGA microspheres can vary significantly between ester-terminated and acid-terminated PLGA. To study the functionality-type distribution (FTD) in PLGA polymers, researchers have used methods such as matrix-assisted laser desorption/ionization – high-resolution mass spectrometry and electrospray ionization – mass spectrometry. However, these methods are typically limited to PLGA polymers with a molecular weight of up to 4kDa. 13Carbon-nuclear-magnetic-resonance has also been used to differentiate and quantify PLGA end groups, but this method is time-consuming, taking over 12 hours per sample. To address these limitations, we have developed a normal-phase liquid chromatography method that can separate FTD and partial chemical composition distribution (CCD) in PLGA polymers. Our method can separate PLGA polymers with a molecular weight of up to 185 kDa and simultaneously separate the difference in lactic acid (LA)/glycolic acid (GA) ratios. To achieve this, we used a cross-linked diol column with a ternary gradient from hexane to 0.1% v/v triethylamine in THF to 0.1% v/v formic acid in THF. This allowed for the elution of ester-terminated PLGA, followed by acid-terminated PLGA. We also separated ester-terminated PLGA in the difference of the LA/GA ratio. Our method is expected to help understand the correlation between PLGA’s FTD, CCD, and physical properties, which will facilitate product development.

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Size-Exclusion Chromatography: A Twenty-First Century Perspective

Striegel

2022

Chromatographia

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Temperature Gradient Interaction Chromatography: A Perspective

Cited by 7 publications

References 45 publications

Modern Herbal Nanogels: Formulation, Delivery Methods, and Applications

Modern Herbal Nanogels: Formulation, Delivery Methods, and Applications

Functionality-type and chemical-composition separation for poly(lactide-co-glycolide) using gradient elution with basic and acidic additives in normal-phase liquid chromatography

Size-Exclusion Chromatography: A Twenty-First Century Perspective

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