Temperature induced helical contraction and expansion in branched polycarbodiimides and their solvent vapor sensing properties

Silva, Enosha Harshani De; Novak, Bruce M.

doi:10.1080/10601325.2021.1978849

Cited by 2 publications

(1 citation statement)

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“…To assess the thermal stability of the secondary conformation of the polymer, 34 CD measurements in THF across a temperature range from 20 to 70 °C were conducted (incubation time = 3 min at each temperature). It was observed that polymers showed remarkable stability as the CD intensity at 223 nm remained unchanged with heating, with consistent UV−vis spectral profiles (Figure 3D).…”

Section: Resultsmentioning

confidence: 99%

Helical Superstructures from the Hierarchical Self-Assembly of Coil–Coil Block Copolymer Guided by Side Chain Amyloid-β(17–19) LVF Peptide

Nayak,

Sarkar,

Bauri

et al. 2024

Biomacromolecules

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The rational design of precisely controlled hierarchical chiral nanostructures from synthetic polymers garnered inspiration from sophisticated biological materials. Since chiral peptide motifs induce helix formation in macromolecules, herein we report the synthesis of a novel type of hybrid polymer consisting of a β-sheet forming a LVF [L = leucine, V = valine, and F = phenylalanine] tripeptide pendant polymethacrylate block and a poly[poly(ethylene glycol) methyl ether methacrylate] (PPEG-MA) block. The designed block copolymer self-organized into helical superstructures with a left-handed twisting sense, as visualized by field emission scanning electron microscopy, transmission electron microscopy, and atomic force microscopy. This intriguing hierarchical self-assembly is driven by the minimalistic peptide motif that itself has a high propensity to adopt an antiparallel β-sheet conformation. We also report the generation of a diverse array of nanostructures, including spherical micelles, spindle micelles, rod-like micelles, vesicles, helical supramolecular fibers, and helical toroids via self-assembly of the designed block copolymer in tetrahydrofuran/water mixed solvents. To realize the observable helical superstructure, a twisted two-dimensional core−shell tape is proposed as a structure model in which the peptide segments form an antiparallel β-sheet with a polymer shell. The findings contribute to the advancement of a helical polymer or the superhelical self-assembly of polymers, paving the way for diverse applications in materials science and related fields.

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Section: Resultsmentioning

confidence: 99%