Temperature influence on non-invasive blood glucose measurement

Zhang, Xiqin; Yeo, Joon Hock

doi:10.1117/12.804281

Cited by 6 publications

(5 citation statements)

References 5 publications

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“…In human non-invasive blood component measurement (NBCM) using near-infrared spectroscopy, fluctuations in skin temperature are big and cannot be ignored 1 . Affected by the physiological state of the human body, the temperature of the skin is fluctuating inevitably.…”

Section: Introductionmentioning

confidence: 99%

Temperature distribution and near-infrared spectral characteristics of the multi-layered skin tissue

Liu,

Lu,

et al. 2023

Optics in Health Care and Biomedical Optics XIII

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Skin temperature fluctuations cannot be ignored in non-invasive human blood composition measurement based on nearinfrared spectroscopy. To effectively address and correct for the interference caused by skin temperature, it is essential to understand the spectral characteristics induced by changes in skin temperature. In this study, we simulated the threedimensional temperature distribution of a five-layered skin model. The goal was to examine how the skin temperature varies with changes in the environmental temperature and the body's core temperature. Additionally, Monte-Carlo simulation was used to obtain the diffuse reflectance spectra. The corresponding spectral characteristics were analyzed.This study can be useful for temperature calibration in non-invasive blood composition measurement in humans.

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Section: Introductionmentioning

confidence: 99%

Temperature distribution and near-infrared spectral characteristics of the multi-layered skin tissue

Liu,

Lu,

et al. 2023

Optics in Health Care and Biomedical Optics XIII

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“…Among many, optical spectroscopic methods have attracted a fair amount of attention (7)(8)(9)(10)(11)(12)(13)(14). While near-infrared (NIR) absorption spectroscopy has demonstrated some potential, extracting glucosespecific features in the presence of many confounding signals from in vivo measurements has been challenging (15)(16)(17)(18)(19)(20)(21). NIR absorption features of glucose in overtone and combination bands are broad and interfere with the absorption of other chromophores in tissue.…”

Section: Introductionmentioning

confidence: 99%

Direct observation of glucose fingerprint using in vivo Raman spectroscopy

et al. 2020

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Noninvasive blood glucose monitoring has been a long-standing dream in diabetes management. The use of Raman spectroscopy, with its molecular specificity, has been investigated in this regard over the past decade. Previous studies reported on glucose sensing based on indirect evidence such as statistical correlation to the reference glucose concentration. However, these claims fail to demonstrate glucose Raman peaks, which has raised questions regarding the effectiveness of Raman spectroscopy for glucose sensing. Here, we demonstrate the first direct observation of glucose Raman peaks from in vivo skin. The signal intensities varied proportional to the reference glucose concentrations in three live swine glucose clamping experiments. Tracking spectral intensity based on linearity enabled accurate prospective prediction in within-subject and intersubject models. Our direct demonstration of glucose signal may quiet the long debate about whether glucose Raman spectra can be measured in vivo in transcutaneous glucose sensing.

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“…5 Zhang et al studied temperature influence on noninvasive blood glucose measurement and the result showed that sample temperature had significant influence on water absorption, which significantly affects the glucose absorption measurement. 6 On the other hand, human tissue is the turbid medium. Changes in temperature can lead to changes both in absorption and scattering properties, thus affecting or even hiding the information of glucose.…”

Section: Introductionmentioning

confidence: 99%

“…10,11 Zhang et al took the temperature of human tissue surface into consideration, which can significantly improve blood glucose prediction accuracy. 6 Chen et al used a referencewavelength-based method to correct the spectra, which can effectively reduce the influence of temperature variations on the sample spectra. 12 Yang et al proposed a floating reference method, 13 which is based on the mechanism that the diffuse reflectance is not affected by the glucose concentration variation at a special radial distance.…”

Section: Introductionmentioning

confidence: 99%

Near-Infrared Diffuse Reflectance Measurement Method Based on Temperature-Insensitive Radial Distance

Liu

2018

Appl Spectrosc

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The variation of temperature is one of the main interference factors that affect the detection accuracy of near-infrared (NIR) diffuse reflectance. In this paper, a measurement method based on temperature-insensitive radial distance was proposed, and its feasibility and effectiveness were verified in Intralipid solutions. First, the possibility of temperature-insensitive radial distance was deduced based on the analytic solution of the steady-state diffusion equation in an infinite media, and the temperature-insensitive radial distances of 3% Intralipid solution in the wavelength range of 1000-1600 nm was calculated. Second, a detection system was designed to measure the diffuse reflectance of 3% Intralipid solutions at multiple radial distances with different glucose concentration (0-100 mM) and different temperatures (35-40 ℃). Both theoretical calculations and experimental results demonstrated the existence of temperature-insensitive radial distances in the range of 1000-1340 nm and 1440-1600 nm, and the distances were hardly affected by glucose variations. Finally, the glucose information extracted from the diffuse reflectance of Intralipid solutions at different radial distances under random temperature variations and constant temperature were compared. The result showed that the correlation between the glucose concentration and the diffuse reflectance obtained at the temperature-insensitive radial distance was significantly better than that of other radial distances, which was almost close to the situation of constant temperature. Therefore, the measurement method based on temperature-insensitive radial distance can effectively reduce the influence of temperature variations on NIR diffuse reflectance, and it is expected to improve the accuracy of diffuse reflectance in human body components detection and industrial field analysis.

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Temperature influence on non-invasive blood glucose measurement

Cited by 6 publications

References 5 publications

Temperature distribution and near-infrared spectral characteristics of the multi-layered skin tissue

Temperature distribution and near-infrared spectral characteristics of the multi-layered skin tissue

Direct observation of glucose fingerprint using in vivo Raman spectroscopy

Near-Infrared Diffuse Reflectance Measurement Method Based on Temperature-Insensitive Radial Distance

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