2022
DOI: 10.3390/v14102178
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Temperature Influences the Interaction between SARS-CoV-2 Spike from Omicron Subvariants and Human ACE2

Abstract: SARS-CoV-2 continues to infect millions of people worldwide. The subvariants arising from the variant-of-concern (VOC) Omicron include BA.1, BA.1.1, BA.2, BA.2.12.1, BA.4, and BA.5. All possess multiple mutations in their Spike glycoprotein, notably in its immunogenic receptor-binding domain (RBD), and present enhanced viral transmission. The highly mutated Spike glycoproteins from these subvariants present different degrees of resistance to recognition and cross-neutralisation by plasma from previously infect… Show more

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Cited by 11 publications
(1 citation statement)
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“…Temperature plays multiple roles in RNA virus transmission, replication, and antiviral immune responses ( 8 ). Low temperatures have been shown to favor spike interaction with its receptor ACE2 ( 9 , 10 ), but the role of hyperthermia in viral entry is not well-characterized.…”
Section: Introductionmentioning
confidence: 99%
“…Temperature plays multiple roles in RNA virus transmission, replication, and antiviral immune responses ( 8 ). Low temperatures have been shown to favor spike interaction with its receptor ACE2 ( 9 , 10 ), but the role of hyperthermia in viral entry is not well-characterized.…”
Section: Introductionmentioning
confidence: 99%