2007
DOI: 10.1016/j.hrthm.2006.10.015
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Temperature modulation of ventricular arrhythmogenicity in a canine tissue model of Brugada syndrome

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Cited by 53 publications
(29 citation statements)
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References 39 publications
(44 reference statements)
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“…Accordingly, we observed a significant decrease of QTc duration with rising body temperature in control patients without LQTS. Indeed, experiments in canine cardiac ventricular preparations have reported action potential shortening at 40°C (27), indicating faster cardiac repolarization at higher temperatures and providing support for the clinical observations. Based on this sharp contrast in QTc response to rising body temperature between the 2 LQT-2 patients and control subjects, we hypothesized that the A558P mutation affects HERG channel function in a temperature-dependent manner.…”
Section: Discussionmentioning
confidence: 58%
“…Accordingly, we observed a significant decrease of QTc duration with rising body temperature in control patients without LQTS. Indeed, experiments in canine cardiac ventricular preparations have reported action potential shortening at 40°C (27), indicating faster cardiac repolarization at higher temperatures and providing support for the clinical observations. Based on this sharp contrast in QTc response to rising body temperature between the 2 LQT-2 patients and control subjects, we hypothesized that the A558P mutation affects HERG channel function in a temperature-dependent manner.…”
Section: Discussionmentioning
confidence: 58%
“…We compared ECG variables at baseline and their changes at peak exercise and during recovery from exercise. ECG analysis at peak exercise was based on experimental and clinical evidence that tachycardia aggravates ST-segment elevation in BrS 7,14 and that BrS-linked loss-of-function mutations in SCN5A reduce I Na more at fast heart rates. 7,15 The fact that we did not find differences in the clinical variables between BrS SCN5AϪ and BrS SCN5Aϩ groups shows that these variables most probably have not confounded the interpretation of ECG differences between groups.…”
Section: Discussionmentioning
confidence: 99%
“…[7][8][9][10][11] Furthermore, occurrence of ventricular arrhythmia at peak exercise has been frequently reported in patients using therapeutic doses of flecainide (a potent Na ϩ channel-blocking drug). 12,13 Indeed, experiments in right ventricular tissue preparations indicate that tachycardia aggravates ST-segment elevation in BrS, 14 and in vitro studies using heterologous expression systems suggest that BrS-linked loss-of-function mutations in SCN5A reduce I Na more at fast heart rates. 7,15 At a molecular level, further I Na reduction in BrS during tachycardia is attributed to accumulation of mutant Na ϩ channels in the slow inactivated state.…”
Section: Clinical Perspective On P 539mentioning
confidence: 99%
“…F: phase 2 reentrant extrasystole triggers a brief episode of polymorphic VT. [Modified from Fish and Antzelevitch (55).] these hypotheses derives from experiments involving the arterially perfused RV wedge preparation (1,55,81,82,156) and from studies in which monophasic action potential electrodes were positioned on the epicardial and endocardial surfaces of the RV outflow tract in patients with Brugada syndrome (13,65). Theoretical simulation models have provided further support and understanding of these mechanisms (40,79).…”
Section: Brugada Syndromementioning
confidence: 99%