Temperature regulation and salivation following preoptic lesions in the rat.

Toth, Delphi M.

doi:10.1037/h0034118

Cited by 28 publications

(11 citation statements)

References 13 publications

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“…The opposite situation, suppression of the ability to keep a stable body temperature while thermoregulatory behavior was increased, has also been observed repeatedly (24, 88, 126,144,149). Suppressed motivation fo r thermoregulatory behavior, with unaffected autonomic responses and normal body temperature, was observed after damage to the lateral hypothalamus in rats (127, 139).…”

Section: The Intimate Link Between the Many Inputs In The Determinamentioning

confidence: 83%

Temperature Regulation

Cabanac¹

1975

Annu. Rev. Physiol.

160

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The general way of looking at short-term temperature regulation has not fundamentaly changed since 1968. Some points nevertheless have been developed and deserve special attention: 1. The influence of water on the skin surface inhibits sweat secretion (55, 106). This fact may be the explanation of sweating fatigue and of discordant conclusions regarding the functioning of the regulator, particularly during exercise in man. 2. Since a large number of studies have shown that appropriate behaviors occur in response to all the stimuli that activate autonomic responses, behavior itself should be considered as an integral part of the thermoregulatory system (1, 2, 16, 18, 19, 21, 23, 25, 31, 32, 34-36, 48, 88, 89, 98, 99, 122, 126, 127, 137). 3. The description of the peripheral input for the control of sweating with regard to mean skin temperature (104) and time dependence (159) has been improved. Among internal temperature sensors those of the spinal cord have been extensively studies (25, 27, 32, 36, 42, 59-63, 71-75, 82, 83, 86, 113-115, 121, 150, 158) and demonstrated to have a sensitivity equal to that of the hypothalamic sensors (73, 75). 4. New hypotheses have been proposed describing the overall mechanism responsible for a constant temperature in the core (58, 96, 97, 135). These stimulating theories have been discussed briefly herein. Mechanisms for the defense against heat and against cold can be dissociated completely from one another. In the same way the control of autonomic responses can be dissociated from the control of behavioral responses. This suggests that temperature regulation is brought about by multiple independent feedback loops. The overall system is well described, in the author's opinion, by the theory of the adjustable set point with proportional control (47).

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Section: The Intimate Link Between the Many Inputs In The Determinamentioning

confidence: 83%

Temperature Regulation

Cabanac¹

1975

Annu. Rev. Physiol.

160

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“…Direct functional evidence in the rat for the presumed involvement of lamina terminalis efferents in the control of salivary function is limited and data are mainly based on lesioning experiments in which destruction of the AV3V, including the OVLT, the ventral median preoptic nucleus and parts of the medial preoptic area or preoptic area lesions influenced submandibular gland morphology and secretion 8,9,11,39 . Now, the neural pathways to the salivary glands postulated on the basis of these functional studies to exist in the rat have been clearly identified by viral tracing (Figs 1,2a).…”

Section: Lamina Terminalis As a Forebrain Site With Visceral Motor Oumentioning

confidence: 99%

“…Interesting in this context is the specific prevention of early viral infection within the lamina terminalis in the parasympathectomized but not sympathectomized animals, indicative of multisynaptic efferent connections either exclusively to the parasympathetic side of the autonomic salivary gland innervation or of a presumambly longer viral transport time via the sympathetic salivary gland innervation. Lesions of the AV3V and the preoptic–anterior hypothalamic area in the rat led to severe deficits in regulating body temperature under heat stress and impaired the secretory function of salivary glands 8–11 . Two major centrifugal pathways emerging from this forebrain area have been described, one taking a midline and the other a more lateral route 67–72 .…”

Section: Lamina Terminalis As a Forebrain Site With Visceral Motor Oumentioning

confidence: 99%

“…Far less data are available concerning a possible role of the lamina terminalis in the control of body temperature. However, lesioning studies of the anteroventral wall of the third ventricle (AV3V) in the rat, which also included parts of the preoptic area or the anterior hypothalamus, led to severe deficits in regulating body temperature under heat stress and clearly affected the thermoregulatory secretory function of salivary glands 8–11 …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Circumventricular Organs: Gateways to the BrainMultisynaptic Neuronal Pathways From The Submandibular And Sublingual Glands To The Lamina Terminalis In The Rat: A Model For The Role Of The Lamina Terminalis In The Control Of Osmo‐ And Thermoregulatory Behaviour

Hübschle

Mathai

Oldfield

2001

Clin Exp Pharma Physio

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SUMMARY 1. The putative regulatory role of the lamina terminalis in the central control of salivation was investigated in the rat using the viral‐tracing technique and Fos‐immunohistochemistry. 2. Neurons situated in the lamina terminalis, such as the vascular organ of the lamina terminalis (OVLT), median preoptic nucleus (MnPO) and subfornical organ (SFO), were retrogradely labelled after pseudorabies virus injections into the submandibular or sublingual gland. 3. Viral tracing combined with glandular denervation showed that lamina terminalis structures sent efferents, in particular, to the parasympathetic side of submandibular gland innervation. 4. Saliva lost under heat stress has severe implications for the body fluid economy of rats and a key to the understanding of the central regulation of heat‐induced salivation may be the integrative role of the lamina terminalis processing thermoregulatory and osmoregulatory information.

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“…In the rat, as in all other species studied, the preoptic area contains neurones directly sensitive to changes in core temperature as well as neurones receiving inputs from peripheral thermoreceptors (Hellon & Taylor, 1982;Ishikawa et al 1984). Lesions in the preoptic area in the rat severely impair or abolish the ability to increase heat loss (Lipton, 1968(Lipton, , 1974Toth, 1973;Ishikawa et al 1984) and localised warming in the preoptic area of the rat at normal body temperatures activates the full range of heat loss behaviour (Lipton, 1973;Roberts & Martin, 1974;Ishikawa et al 1984;Nakayama et al 1986;Tanaka et al 1986;Kanosue et al 1990Kanosue et al , 1991. Neurones in the preoptic area of the rat also project to a wide range of midbrain and brainstem nuclei involved in autonomic functions, including those involved in the generation and control of breathing (Conrad & Pfaff, 1975, 1976Swanson, 1976;Veening et al 1982;Simerly & A. G. Boden, M. C. Harris and M. J. Parkes Exp.…”

Section: Hypothalamus and Thermoregulationmentioning

confidence: 99%