Temperature resolved second harmonic generation to probe the structural purity of m-hydroxybenzoic acid

Clevers, Simon; Simon, F.; Dupray, Valérie; Coquerel, Gérard

doi:10.1007/s10973-012-2763-y

Cited by 17 publications

(32 citation statements)

References 23 publications

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“…This constitutes more work than the construction of the binary system. Thus, application of the SHG method can only constitute a prescreening, but it is still interesting because: (1) no comparison with the crystal lattice of the corresponding pure enantiomer is required; (2) it is almost instantaneous; (3) it is nondestructive; (4) a small amount of solid (often w10 mg is enough) is required; (5) it can be run in an automatic way; (6) it can operate at different temperatures [58,59], and (7) it works on suspensions, which means that efflorescent solvate conglomerates can be detected as well. 3.…”

Section: Construction Of Ternary Phase Diagram Between Antipodes and mentioning

confidence: 99%

Crystallization of Chiral Molecules

Viedma

Coquerel

Cintas

2015

Handbook of Crystal Growth

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Section: Construction Of Ternary Phase Diagram Between Antipodes and mentioning

confidence: 99%

Crystallization of Chiral Molecules

Viedma

Coquerel

Cintas

2015

Handbook of Crystal Growth

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“…4 shows a classical P-SHG apparatus and the TR-SHG apparatus fully described in reference [33]. The use of a near-infrared laser (e.g., Nd:YAG) is of particular interest because of its affordable cost compared to other sources.…”

Section: Experimental Setup For P-shg and Tr-shgmentioning

confidence: 99%

“…On the other hand, a solid is 'structurally impure' when it corresponds to a mixture of several polymorphs, but also when amorphous contents or solvates are present. 9), whereas XRPD and DSC showed a detection threshold of 1 and 17 wt %, respectively [33]. 3-Hydroxybenzoic acid (3-HBA) is an organic compound having two monotropically related polymorphic forms [33,38].…”

Section: Example 2: Study Of the Structural Purity Of 3-hydroxybenzoimentioning

confidence: 99%

Relevance of the Second Harmonic Generation to Characterize Crystalline Samples

et al. 2015

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The application of powder second harmonic generation (P-SHG), temperatureresolved SHG (TR-SHG), and SHG microscopy (SHGM) in the characterization of bulk crystalline samples is illustrated. P-SHG applied to powder samples can be an extremely sensitive approach to detect the absence of an inversion center in crystalline structures, TR-SHG serves to monitor temperature-induced phase transitions, and SHGM is used in the detection of non-centrosymmetric zones inside a heterogeneous material. These methods are of great relevance, e.g., in the pharmaceutical industry where crystalline active pharmaceutical ingredients are often made of a single enantiomer and are therefore non-centrosymmetric. Herein, several examples are provided to describe how a given SHG signal should be interpreted. A general procedure to carry out a P-SHG experiment is illustrated in detail.

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“…SHG was formerly proposed as a rapid, reliable and very sensitive test of non-centrosymmetry for powdered crystalline compounds [2] with applications to structure assignments and pre-screening of conglomerates [3]. It was also proposed as an efficient technique for the quantification of a crystalline phase inside an amorphous matrix [4] and, recently, we demonstrated that SHG can be used to assess the structural purity of an organic compound down to the ppm level [5].…”

Section: Introductionmentioning

confidence: 99%