Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery

Bromberg, Lev

doi:10.1016/s0169-409x(97)00121-x

Cited by 785 publications

(539 citation statements)

References 174 publications

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“…Chitosan-based nanoparticles designed for encapsulation of hydrophilic drugs were prepared by Chuang et al [19], by grafting chitosan with poly(N-isopropyl acrylamide) (PNIPAM), a well-known temperature-responsive polymer [72,73] used in DDSs [74][75][76]. The graft copolymer was obtained by polymerizing N-isopropyl acrylamide in the presence of chitosan.…”

Section: Temperature-responsive Chitosan Nanoparticlesmentioning

confidence: 99%

Self-assembled polysaccharide nanostructures for controlled-release applications

Myrick

Vendra

Krishnan

2014

Nanotechnology Reviews

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Self-assembling polysaccharide nanostructures have moved to the forefront of many fields due to their wide range of functional properties and unique advantages, including biocompatability and stimulus responsiveness. In particular, the field of controlled release, which involves influencing the location, concentration, and efficacy of active pharmaceutical ingredients (APIs), diagnostics, nutrients, or other bioactive compounds, has benefited from polysaccharide biomaterials. Nanostructure formation, stimulus responsiveness, and controlledrelease performance can be engineered through facile chemical functionalization and noncovalent intermolecular interactions. This review discusses polysaccharide nanoparticles, designed for targeted and time-controlled delivery of emerging APIs, with improved in vivo retention, stability, solubility, and permeability characteristics. Topics covered include nanoparticles of cyclodextrin and cyclodextrin-containing polymers, hydrophobically modified polysaccharides, polysaccharide nanoparticles that respond to pH, temperature, or light stimulus, polysaccharide prodrug complexes, polysaccharide complexes with lipids and proteins, and other polysaccharide polyelectrolyte complexes.

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Section: Temperature-responsive Chitosan Nanoparticlesmentioning

confidence: 99%

Self-assembled polysaccharide nanostructures for controlled-release applications

Myrick

Vendra

Krishnan

2014

Nanotechnology Reviews

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“…A large number of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) block copolymers have been found to possess an inverse temperature-sensitive micellization and gelation potential, and are commercially available under the names of Pluronics ® (or, Poloxamers ® ) and Tetronics® [201]. Specifically, Pluronics (e.g., commercially available PF127 which is a PEO-b-PPO-b-PEO triblock copolymer) have distinct amphiphilic properties and the ability to from thermally reversible non-crosslinked gels.…”

Section: Temperature-sensitive or Thermo-responsive Gelsmentioning

confidence: 99%

Smart polymeric gels: Redefining the limits of biomedical devices

Chaterji

Kwon

Park

2007

Progress in Polymer Science

559

364

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This review describes recent progresses in the development and applications of smart polymeric gels, especially in the context of biomedical devices. The review has been organized into three separate sections: defining the basis of smart properties in polymeric gels; describing representative stimuli to which these gels respond; and illustrating a sample application area, namely, microfluidics. One of the major limitations in the use of hydrogels in stimuli-responsive applications is the diffusion rate limited transduction of signals. This can be obviated by engineering interconnected pores in the polymer structure to form capillary networks in the matrix and by downscaling the size of hydrogels to significantly decrease diffusion paths. Reducing the lag time in the induction of smart responses can be highly useful in biomedical devices, such as sensors and actuators. This review also describes molecular imprinting techniques to fabricate hydrogels for specific molecular recognition of target analytes. Additionally, it describes the significant advances in bottom-up nanofabrication strategies, involving supramolecular chemistry. Learning to assemble supramolecular structures from nature has led to the rapid prototyping of functional supramolecular devices. In essence, the barriers in the current performance potential of biomedical devices can be lowered or removed by the rapid convergence of interdisciplinary technologies.

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“…Each association produces a contribution to the free energy of gkT per each of the chain segments involved. The mean field estimate of the free energy of configurations with a fraction Γ of actually associated elements gives the contribution to the free energy as: (3) For each given temperature and concentration, the actual association rate Γ is determined from minimization of the free energy with respect to that variable.…”

Section: Model and Phase Equilibrium Conditionsmentioning

confidence: 99%

Control of Gel Swelling and Phase Separation of Weakly Charged Thermoreversible Gels by Salt Addition

Solis

Vernon

2007

Macromolecules

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Doping of thermoreversible polymer gels with charged monomers provides a way to control phase separation and gelation conditions by coupling the properties of the gel with a tunable ionic environment. We analyze the dependence of the gelation and phase separation conditions on the amount of salt present using a mean field model of weakly charged associative polymers. The ions and co-ions present are explicitly considered at the mean field level, and we determine their concentrations in the different equilibrium phases when the system undergoes phase separation. For weak polymer charge, the entropic contributions of the ions to the free energy of the system play a central role in the determination of the location of phase equilibrium. In the simplest case, when the associative interaction responsible for gel formation is independent of the electrostatic interaction, the addition of salt changes the polymer equilibrium concentrations and indirectly changes the measurable swelling of the gel. We construct phase diagrams of these systems showing the location of the coexistence region, the gel-sol boundary and the location of the tie-lines. We determine the swelling of the gel within the co-existence region. Our main result is that the description of the effect of the salt on the properties of the weakly charged gel can be described through an extra contribution to the effective immiscibility parameter χ proportional to the square of the doping degree f 2 and to the inverse square of the added salt concentration s −2 .

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Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery

Cited by 785 publications

References 174 publications

Self-assembled polysaccharide nanostructures for controlled-release applications

Self-assembled polysaccharide nanostructures for controlled-release applications

Smart polymeric gels: Redefining the limits of biomedical devices

Control of Gel Swelling and Phase Separation of Weakly Charged Thermoreversible Gels by Salt Addition

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