Temperature responsive hydrogel magnetic nanocomposites for hyperthermia and metal extraction applications

Reddy, Narendra; Ravindra, S.; Reddy, N. Madhava; Rajinikanth, V.; Raju, K. Mohana; Vallabhapurapu, Vijaya Srinivasu

doi:10.1016/j.jmmm.2015.06.065

Cited by 21 publications

(16 citation statements)

References 51 publications

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“…The results indicate that the hybridization process has not resulted in any phase change of the magnetic iron oxide (Fe 3 O 4 ) or there is no additional magnetic phase that has been introduced into the magnetic hydrogel nanocomposites during the preparation process, and thus the synthesized PAAVSA/iron oxide hydrogel maintains the magnetic functions of Fe 3 O 4 . 35 The results are also supported by the findings from the Raman scattering study, as discussed in the next section.…”

Section: Results and Discussionsupporting

confidence: 74%

Target-Specific Superparamagnetic Hydrogel with Excellent pH Sensitivity and Reversibility: A Promising Platform for Biomedical Applications

2020

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Superparamagnetism has been widely used for many biomedical applications, such as early detection of inflammatory cancer and diabetes, magnetic resonance imaging (MRI), hyperthermia, etc., whereas incorporation of superparamagnetism in stimulus-responsive hydrogels has now gained substantial interest and attention for application in these fields. Recently, pH-responsive superparamagnetic hydrogels showing the potential use in disease diagnosis, biosensors, polymeric drug carriers, and implantable devices, have been developed based on the fact that pH is an important environmental factor in the body and some disease states manifest themselves by a change in the pH value. However, improvement in pH sensitivity of magnetic hydrogels is a dire need for their practical applications. In this study, we report the distinctly high pH sensitivity of new synthesized dual-responsive magnetic hydrogel nanocomposites, which was accomplished by copolymerization (free-radical polymerization) of two pH-sensitive monomers, acrylic acid (AA) and vinylsulfonic acid (VSA) with an optimum ratio, in the presence of presynthesized superparamagnetic iron oxide nanoparticles (Fe 3 O 4 (OH) x ). The monomers contain pH-sensitive functional groups (COO – and SO 3 – for AA and VSA, respectively), and they have also been widely used as biomaterials because of the good biocompatibility. The pH sensitivity of the superparamagnetic hydrogel, poly(acrylic acid- co -vinylsulfonic acid), PAAVSA/Fe 3 O 4 , was investigated by swelling studies at different pH values from pH 7 to 1.4. Distinct pH reversibility of the system was also demonstrated through swelling/deswelling analysis. Thermal stability, chemical configuration, magnetic response, and structural properties of the system have been explored by suitable characterization techniques. Furthermore, the study reveals a pH-responsive significant change in the overall morphology and packing fraction of iron oxide nanoparticles in PAAVSA/Fe 3 O 4 via energy-dispersive X-ray (EDX) elemental mapping with the field emission scanning electron microscopy (FESEM) study (for freeze-dried PAAVSA/Fe 3 O 4 , swelled at different pH values), implying a drastic change in susceptibility and induced saturation magnetization of the system. These important features could be easily utilized for the purpose of diagnosis using magnetic probe and/or impedance analysis techniques.

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Section: Results and Discussionsupporting

confidence: 74%

Target-Specific Superparamagnetic Hydrogel with Excellent pH Sensitivity and Reversibility: A Promising Platform for Biomedical Applications

2020

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“…This frequency is in the range for biomedical applications, since the human tissue is transparent in that frequency range. 48 Experiments were made during 420 seconds, taking photographs at initial and nal states. The temperature of each material was measured on the surface with an infrared thermometer (TES 1326 s/1327K).…”

Section: Material's Characterizationmentioning

confidence: 99%

Electromagnetic radiation driving of volume changes in nanocomposites made of a thermosensitive hydrogel polymerized around conducting polymer nanoparticles

et al. 2020

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“…In the future, the development of magnetic hydrogels to a great extent depends on the synthesis of novel hydrogels with multiple functionalities. Combining magnetic stimuli with others, such as pH, temperature and redox, magnetic hydrogels could become more intelligent and multifunctional. Magnetic field therapies using hydrogels with MNPs could direct and control cell processes, such as proliferation, migration and differentiation, which is suitable for culture of stem cells upon implantation.…”

Section: Discussionmentioning

confidence: 99%

Recent advances in magnetic hydrogels

Zhang

Huang

2016

Polymer International

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Smart hydrogels that respond to magnetic field have attracted increasing interest in recent years. This is as a result of their numerous potential applications such as tunable delivery vehicles, magnetic resonance imaging (MRI) contrast agents and magnetic-heat therapy, etc. In this review, we summarize the methods for preparing magnetic hydrogels. Then we give an overview of magnetic hydrogels with various applications. Finally, the current limitations in the preparation and application of magnetic hydrogels will be discussed and the perspectives will be proposed for next generation of hydrogels.

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Temperature responsive hydrogel magnetic nanocomposites for hyperthermia and metal extraction applications

Cited by 21 publications

References 51 publications

Target-Specific Superparamagnetic Hydrogel with Excellent pH Sensitivity and Reversibility: A Promising Platform for Biomedical Applications

Target-Specific Superparamagnetic Hydrogel with Excellent pH Sensitivity and Reversibility: A Promising Platform for Biomedical Applications

Electromagnetic radiation driving of volume changes in nanocomposites made of a thermosensitive hydrogel polymerized around conducting polymer nanoparticles

Recent advances in magnetic hydrogels

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