Temperature Responsive Solution Partition of Organic–Inorganic Hybrid Poly(N‐isopropylacrylamide)‐Coated Mesoporous Silica Nanospheres

Abstract

A series of poly(N‐isopropylacrylamide)‐coated mesoporous silica nanoparticle materials (PNiPAm‐MSNs) has been synthesized by a surface‐initiated living radical polymerization with a reversible addition–fragmentation chain transfer (RAFT) reaction. The structure and the degree of polymerization of the PNiPAm‐MSNs has been characterized by a variety of techniques, including nitrogen sorption analysis, 29Si and 13C solid‐state NMR spectroscopy, transmission electron microscopy (TEM), and powder X‐ray diffraction (XRD). The thermally induced changes of the surface properties of these polymer‐coated core–shell nanoparticles have been determined by examining their partition activities in a biphasic solution (water/toluene) at different temperatures.

Transition temperature control of adsorption–desorption property of PNIPAM / mesoporous silica composite by addition of crosslinking agent

“…Moreover, the surface area for samples with PNIPAM was about 740 m 2 /g (measured by nitrogen adsorption experiments), which was almost the same as that reported previously for the sample without PNIPAM (640-860 m 2 /g) [22]. Chung et al reported that the thickness of the PNIPAM layer was 19 nm when the mesoporous silica was coated with about 7 wt.% of PNIPAM [26]. Consequently, it was expected that the PNIPAM would be present as a thin layer of less than 10 nm on the external surface of the mesoporous silica.…”

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

“…Other researchers also investigated the PNIPAM-based thermo-responsive DDS using MSN as the drug container. [130][131][132][133][134][135][136] This new core-shell thermo-responsive nanocarrier showed promising potential in controlled drug/gene delivery.…”

Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers

“…This strategy can be utilised to prepare stimuli responsive MSN based nanovalves, where drugs can be loaded inside the porous structure and released at a certain temperature. 149 Using the novel W/O pickering emulsion based technique and solid silica sphere as a stabiliser, Zhang et al prepared temperature responsive hybrid capsules made up of PNIPAm and polymethyl methacrylates (PMMA). Ibuprofen release from the composite particles was controlled by temperature and wall thickness of the polymer.…”