Temperature Sculpting in Yoctoliter Volumes

Reiner, Joseph E.; Robertson, Joseph W. F.; Burden, Daniel L.; Burden, Lisa M.; Balijepalli, Arvind; Kasianowicz, John J.

doi:10.1021/ja309892e

Cited by 54 publications

(82 citation statements)

References 108 publications

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“…optical tweezers and microfluidic chambers 10 5−6 K/m, 46,47 fields of the order of 10 1−2 V/m could be generated at near ambient conditions while these fields could be higher, e.g. 10 2−4 V/m for the stronger thermal gradients, ∼ 10 6−8 K/m, that can be generated using metallic particles and other plasmonic structures [48][49][50] . The results presented in our work using the TIP4P/2005 model are consistent with the existence of a temperature inversion in the thermal polarization coefficient of SPC/E water.…”

Section: Conclusion and Final Remarksmentioning

confidence: 99%

The rich phase behavior of the thermopolarization of water: from a reversal in the polarization, to enhancement near criticality conditions

Iriarte-Carretero

Gonzalez

Armstrong

et al. 2016

Phys. Chem. Chem. Phys.

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We investigate using non-equilibrium molecular dynamics simulations the polarization of water induced by thermal gradients using the accurate TIP4P/2005 water model. The full dependence of the polarization covering a wide range of thermodynamic states, from near supercritical to ambient conditions, is reported. Our results show a strong dependence of the thermo-polarization field with the thermodynamic state. The field features a strong enhancement near the critical point, which can be rationalized in terms of the large increase and ultimately the divergence of the thermal expansion of the fluid at the critical temperature. We also show that the TIP4P/2005 model features a reversal in the sign of the thermal polarization at densities ∼ 1 g/cm 3 . The latter result is consistent with the recent observation of this reversal phenomenon in SPC/E water and points the existence of this general physical phenomenon in water.

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Section: Conclusion and Final Remarksmentioning

confidence: 99%

The rich phase behavior of the thermopolarization of water: from a reversal in the polarization, to enhancement near criticality conditions

Iriarte-Carretero

Gonzalez

Armstrong

et al. 2016

Phys. Chem. Chem. Phys.

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“…We recently tethered gold nanoparticles to the cap of the alpha-hemolysin (αHL) nanopore as a means of optically inducing a temperature change in proximity to the pore. 28 Using this concept, temperature modulation could be used to generate reaction products in a reversible fashion (e.g., temporarily melting double stranded DNA segments). Alternatively, locally enhanced temperatures could be used to momentarily increase the rate of chemical catalysis for an otherwise unfavorable reaction.…”

Section: + ⇄ a B Cmentioning

confidence: 99%

Proximal Capture Dynamics for a Single Biological Nanopore Sensor

et al. 2015

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Single nanopore sensors enable capture and analysis of molecules that are driven to the pore entry from bulk solution. However, the distance between an analyte and the nanopore opening limits the detection efficiency. A theoretical basis for predicting particle capture rate is important for designing modified nanopore sensors, especially for those with covalently tethered reaction sites. Using the finite element method, we develop a soft-walled electrostatic block (SWEB) model for the alpha-hemolysin channel that produces a vector map of drift-producing forces on particles diffusing near the pore entrance. The maps are then coupled to a single-particle diffusion simulation to probe capture statistics and to track the trajectories of individual particles on the μs to ms time scales. The investigation enables evaluation of the interplay among the electrophoretic, electroosmotic, and thermal driving forces as a function of applied potential. The findings demonstrate how the complex drift-producing forces compete with diffusion over the nanoscale dimensions of the pore. The results also demonstrate the spatial and temporal limitations associated with nanopore detection and offer a basic theoretical framework to guide both the placement and kinetics of reaction sites located on, or near, the nanopore cap.

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“…Metal nanoparticles and metal nanostructures can be used as nanoheaters that convert light into heat. This property is being exploited to set up nanoscale mass fluxes 7,8 and in thermal therapy applications, where the nanoparticles can bind specifically to cells. It has been shown that the temperature next to the particle can increase by hundreds of degrees, resulting in the explosive evaporation of the fluid, a phenomenon that takes place in subnanosecond timescales 9 .…”

Section: Introductionmentioning

confidence: 99%

Thermal transport across nanoparticle–fluid interfaces: the interplay of interfacial curvature and nanoparticle–fluid interactions

Tascini

Armstrong

Chiavazzo

et al. 2017

Phys. Chem. Chem. Phys.

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We investigate the general dependence of the thermal transport across nanoparticle-fluid interfaces using molecular dynamics computations. We show that the thermal conductance depends strongly both on the wetting characteristics of the nanoparticle-fluid interface as well as on the nanoparticle size. Strong nanoparticle-fluid interactions, leading to full wetting states in the host fluid, result in high thermal conductances and efficient interfacial transport of heat. Weak interactions result in partial drying or full drying states and low thermal conductances. The variation of the thermal conductance with particle size is found to depend on the fluid-nanoparticle interactions. Strong interactions coupled with large interfacial curvatures lead to optimum interfacial heat transport. This complex dependence can be modelled with an equation that includes the interfacial curvature as parameter. In this way we rationalise existing experimental and computer simulation results and show that the thermal transport across nanoscale interfaces is determined by the correlations of both interfacial curvature and nanoparticle-fluid interactions.

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Temperature Sculpting in Yoctoliter Volumes

Cited by 54 publications

References 108 publications

The rich phase behavior of the thermopolarization of water: from a reversal in the polarization, to enhancement near criticality conditions

The rich phase behavior of the thermopolarization of water: from a reversal in the polarization, to enhancement near criticality conditions

Proximal Capture Dynamics for a Single Biological Nanopore Sensor

Thermal transport across nanoparticle–fluid interfaces: the interplay of interfacial curvature and nanoparticle–fluid interactions

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