Temperature-sensitive amorphous magnetic flakes for intratissue hyperthermia

Matsuki, H.; Yanada, T.; Sato, Tomoya; Murakami, K.; Minakawa, S.

doi:10.1016/0921-5093(94)90865-6

Cited by 38 publications

(17 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One technique for nanoparticle delivery in solid tumors is intratumoral infusion [12,13,24,26]. After injection, the spatial distribution of the particles in tissue is a main factor that determines nanoparticle-induced heat generation distribution and temperature elevation [38].…”

Section: Introductionmentioning

confidence: 99%

Multi-scale study of nanoparticle transport and deposition in tissues during an injection process

Salloum

et al. 2010

Med Biol Eng Comput

View full text Add to dashboard Cite

In magnetic nanoparticle hyperthermia for cancer treatment, controlling the nanoparticle distribution delivered in tumors is vital for achieving an optimum distribution of temperature elevations that enables a maximum damage of the tumorous cells while minimizing the heating in the surrounding healthy tissues. A multi-scale model is developed in this study to investigate the spatial distribution of nanoparticles in tissues after nanofluid injection into the extracellular space of tissues. The theoretical study consists of a particle trajectory tracking model that considers particle-surface interactions and a macroscale model for the transport of nanoparticles in the carrier solution in a porous structure. Simulations are performed to examine the effects of a variety of injection parameters and particle properties on the particle distribution in tissues. The results show that particle deposition on the cellular structure is the dominant mechanism that leads to a non-uniform particle distribution. The particle penetration depth is sensitive to the injection rate and surface properties of the particles, but relatively insensitive to the injected volume and concentration of the nanofluid.

show abstract

Section: Introductionmentioning

confidence: 99%

Multi-scale study of nanoparticle transport and deposition in tissues during an injection process

Salloum

et al. 2010

Med Biol Eng Comput

View full text Add to dashboard Cite

show abstract

“…Intratumoral infusion is an important technique to deliver a variety of nanostructures in tumors by continuous injection of a nanofluid under a positive pressure gradient [1,11,12,21]. Since it allows those agents to overcome obstacles such as interstitial fluid pressure and brain blood barrier through enhanced convective transport [22], direct infusion is considered the best method available for distributing large therapeutic agents in tumors.…”

Section: Introductionmentioning

confidence: 99%

Numerical study of nanofluid infusion in deformable tissues for hyperthermia cancer treatments

Zhu

2011

Med Biol Eng Comput

View full text Add to dashboard Cite

Direct infusion by means of needles is one of the widely used methods for the delivery of nanoparticles in tumors for hyperthermia cancer treatments. During an infusion process, infusion-induced deformation can substantially affect the dispersion of the nanoparticles injected in a biological tissue. In this study, a poroelastic model is developed to investigate fluid transport and flow-induced tissue deformation in a tumor during an infusion process. A surface tracking technique is employed to predict the shape of nanofluid spreading after injection. The model is then used to simulate the formation of backflow and the change of tissue porosity due to the deformation. Specifically, we quantify the influence of the backflow on the spreading shape of the nanofluid and its dependence on injection parameters such as infusion rates, needle diameters, and tumor elastic properties. It is found that backflow is an important factor causing an irregular distribution of the nanofluid injected in a tumor. A higher infusion rate, larger needle diameter, and lower elastic modulus yield a longer backflow length and cause a more irregular spreading shape of the nanofluid. The infusion-induced tissue deformation also leads to a pore swelling and an increase of the porosity in the vicinity of the needle tip and the needle outer surface. It is anticipated that the increased pore size may facilitate the particle penetration in a tumor. To achieve a controlled heat generation, the injection parameters should be selected judiciously with the consideration of tumor sizes, tumor properties, and thresholds at which tumors break under the infusion pressure.

show abstract

“…The authors heated up various damaged tissue samples with 20-100 nm size particles of -Fe 2 O 3 exposed to a 1.2 MHz magnetic field. Since then the scientists have been developing numerous methods and schemes using different types of magnetic materials, different field strengths and frequencies of encapsulation and delivery of the www.intechopen.com particles (Mosso et al, 1973, Rand et al, 1976, Gordon et al, 1979, Rand et al, 1981, Borrelli et al, 1984, Hase et al, 1990, Suzuki et al, 1990, Chan et al, 1993, Matsuki et al, 1994, Mitsumori et al, 1994, Suzuki et al, 1995, Moroz et al, 2001, Jones et al, 2002. The hyperthermia procedure involves the dispersion of the magnetic particles throughout the target tissue, followed by applying an AC magnetic field with specific parameters (frequency, strength); the magnetization of the particles is continuously reversed, which translates into a conversion from magnetic to thermal energy and causes the heating of particles.…”

Section: Oxidation Stabilitymentioning

confidence: 99%

Tailored and Functionalized Magnetite Particles for Biomedical and Industrial Applications

Durdureanu-Angheluta¹,

Pinteală²,

Simionescu³

2012

Materials Science and Technology

View full text Add to dashboard Cite

Temperature-sensitive amorphous magnetic flakes for intratissue hyperthermia

Cited by 38 publications

References 4 publications

Multi-scale study of nanoparticle transport and deposition in tissues during an injection process

Multi-scale study of nanoparticle transport and deposition in tissues during an injection process

Numerical study of nanofluid infusion in deformable tissues for hyperthermia cancer treatments

Tailored and Functionalized Magnetite Particles for Biomedical and Industrial Applications

Contact Info

Product

Resources

About