Temperature-Sensitive poly(<i>N</i>-Isopropylacrylamide-Co-Butyl Methylacrylate) Nanogel as an Embolic Agent: Distribution, Durability of Vascular Occlusion, and Inflammatory Reactions in the Renal Artery of Rabbits

Zhao, Hui; Zheng, Chuansheng; Gao, Feng; Zhao, Yufang; Liang, Hong; Wu, Hao; Zhou, Guofeng; Liang, Buqing; Wang, Y.; Xia, Xun

doi:10.3174/ajnr.a3177

Cited by 30 publications

(29 citation statements)

References 27 publications

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“…Angiographic images were taken of the renal arteries before embolization and at 5 min and 30 min after embolization. After the radiography procedure, the femoral artery was bound, and the animals were returned to the laboratory [37]. …”

Section: Methodsmentioning

confidence: 99%

Thermo-sensitive composite hydrogels based on poloxamer 407 and alginate and their therapeutic effect in embolization in rabbit VX2 liver tumors

Huang

Shen

et al. 2016

Oncotarget

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Interventional embolization therapy is an effective, most widely used method for inoperable liver tumors. Blood-vessel-embolic agents were essential in transarterial embolization (TAE). In this work, thermo-sensitive composite hydrogels based on poloxamer 407, sodium alginate, hydroxymethyl cellulose and iodixanol (PSHI), together with Ca2+ (PSHI-Ca2+) were prepared as liquid embolic agents for TAE therapy to liver cancer. With increasing temperature, PSHI exhibited two phase states: a flowing sol and a shrunken gel. Rheology tests showed good fluidity and excellent viscoelastic behavior with a gelation temperature (GT) of 26.5°C. The studies of erosion indicated that PSHI had calcium ion-related erosion characteristics and showed a slow erosion rate in an aqueous environment. When incubated with L929 cells, the thermo-sensitive composite hydrogels had low cytotoxicity in vitro. The results of analyzing the digital subtraction angiography and computed tomography images obtained from in vitro and in vivo assays indicated a good embolic effect in the renal arteries of normal rabbits. Angiography and histological studies on VX2 tumor-bearing rabbits indicated that PSHI-Ca2+ successfully occluded the tumors, including the peripheral vessels. In conclusion, PSHI-Ca2+ was a promising embolic agent for transarterial embolization therapy.

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Section: Methodsmentioning

confidence: 99%

Thermo-sensitive composite hydrogels based on poloxamer 407 and alginate and their therapeutic effect in embolization in rabbit VX2 liver tumors

Huang

Shen

et al. 2016

Oncotarget

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“…Unlike conventional biomaterials, it presents as liquid state at room temperature and solidifies at body temperature. 15,17 Hydrogels are quite similar to natural living tissues, due to their ability to retain a significant amount of water or biological fluids. They are three-dimensional, hydrophilic, polymeric networks which can be used as bone substitutes and drug delivery systems.…”

Section: Discussionmentioning

confidence: 99%

“…34 PIB nanogels possess all three of these properties but lack some of the mechanical properties offered by ceramic scaffolds. 15,17 Furthermore, the material itself undergoes material shrinkage when passing from the liquid phase at room temperature to the hardened phase at body temperature. Thus their use alone for bone tissue repair comes with certain disadvantages.…”

Section: Discussionmentioning

confidence: 99%

“…It can be used to treat defects of irregular shapes and deformities as an injectable, thermoresponsive, biocompatible hydrogel for tissue engineering applications which undergoes rapid thermal gelation once the sol form reaches body temperature. 15,16 Recently, PIB nanogels have been applied in interventional therapy for liver tumors and vascular occlusion of renal artery as a novel blood-vesselembolic material. 15,17 However to date, no study has applied this new technology for the repair of bone defects.…”

Section: Introductionmentioning

confidence: 99%

“…15,16 Recently, PIB nanogels have been applied in interventional therapy for liver tumors and vascular occlusion of renal artery as a novel blood-vesselembolic material. 15,17 However to date, no study has applied this new technology for the repair of bone defects. Therefore, the aim of the present study was to investigate the role of PIB nanogels as a bone substitute material for the repair of femur defects in rats.…”

Section: Introductionmentioning

confidence: 99%

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In vivo experimental study on bone regeneration in critical bone defects using PIB nanogels/boron-containing mesoporous bioactive glass composite scaffold

Chen¹,

Zhao²,

Geng³

et al. 2015

IJN

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Purpose In the present study, the fabrication of novel p(N-isopropylacrylamide-co-butyl methylacrylate) (PIB) nanogels was combined with boron-containing mesoporous bioactive glass (B-MBG) scaffolds in order to improve the mechanical properties of PIB nanogels alone. Scaffolds were tested for mechanical strength and the ability to promote new bone formation in vivo. Patients and methods To evaluate the potential of each scaffold in bone regeneration, ovariectomized rats were chosen as a study model to determine the ability of PIB nanogels to stimulate bone formation in a complicated anatomical bone defect. PIB nanogels and PIB nanogels/B-MBG composites were respectively implanted into ovariectomized rats with critical-sized femur defects following treatment periods of 2, 4, and 8 weeks post-implantation. Results Results from the present study demonstrate that PIB nanogels/B-MBG composites showed greater improvement in mechanical strength when compared to PIB nanogels alone. In vivo, hematoxylin and eosin staining revealed significantly more newly formed bone in defects containing PIB nanogels/B-MBG composite scaffolds when compared to PIB nanogels alone. Tartrate-resistant acid phosphatase-positive staining demonstrated that both scaffolds were degraded over time and bone remodeling occurred in the surrounding bone defect as early as 4 weeks post-implantation. Conclusion The results from the present study indicate that PIB nanogels are a potential bone tissue engineering biomaterial able to treat defects of irregular shapes and deformities as an injectable, thermoresponsive, biocompatible hydrogel which undergoes rapid thermal gelation once body temperature is reached. Furthermore, its combination with B-MBG scaffolds improves the mechanical properties and ability to promote new bone formation when compared to PIB nanogels alone.

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Advances in Biomaterials and Technologies for Vascular Embolization

et al. 2019

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Minimally invasive transcatheter embolization is a common nonsurgical procedure in interventional radiology used for the deliberate occlusion of blood vessels for the treatment of diseased or injured vasculature. A wide variety of embolic agents including metallic coils, calibrated microspheres, and liquids are available for clinical practice. Additionally, advances in biomaterials, such as shapememory foams, biodegradable polymers, and in situ gelling solutions have led to the development of novel pre-clinical embolic agents. The aim here is to provide a comprehensive overview of current and emerging technologies in endovascular embolization with respect to devices, materials, mechanisms, and design guidelines. Limitations and challenges in embolic materials are also discussed to promote advancement in the field.

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Temperature-Sensitive poly(N-Isopropylacrylamide-Co-Butyl Methylacrylate) Nanogel as an Embolic Agent: Distribution, Durability of Vascular Occlusion, and Inflammatory Reactions in the Renal Artery of Rabbits

Cited by 30 publications

References 27 publications

Thermo-sensitive composite hydrogels based on poloxamer 407 and alginate and their therapeutic effect in embolization in rabbit VX2 liver tumors

Thermo-sensitive composite hydrogels based on poloxamer 407 and alginate and their therapeutic effect in embolization in rabbit VX2 liver tumors

In vivo experimental study on bone regeneration in critical bone defects using PIB nanogels/boron-containing mesoporous bioactive glass composite scaffold

Advances in Biomaterials and Technologies for Vascular Embolization

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