Temperature-sensitive poly(N-isopropylacrylamide)-chitosan hydrogel for fluorescence sensors in living cells and its antibacterial application

Xu, Lifeng; Liang, Xiao; You, Liru; Yang, Yi; Fen, Gangying; Gao, Yan; Cui, Xuejun

doi:10.1016/j.ijbiomac.2021.08.057

Cited by 29 publications

(16 citation statements)

References 30 publications

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“…Commonly used temperature-sensitive polymers include poly(N-isopropyl acrylamide) (PNIPAAm) and polyethylene glycol (PEG). The thermally reversible phase transition temperature of PNIPAAm is 32 °C, close to the human body surface temperature [ 81 ].…”

Section: Hydrogel Eye Drops For Dry Eye Treatmentmentioning

confidence: 99%

Recent Advances in Hydrogels for the Diagnosis and Treatment of Dry Eye Disease

Cao

Wang

2022

Gels

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Dry eye disease (DED) is the most common clinical ocular surface disease. Given its multifactorial etiology, no consensus has been reached on the diagnosis criteria for dry eye disease. Topical drug administration remains the mainstay of treatment but is limited to the rapid clearance from the eye surface. To address these problems, hydrogel-based materials were designed to detect biomarkers or act as drug delivery systems by taking advantage of their good biocompatibility, excellent physical and mechanical properties, and long-term implant stability. Biosensors prepared using biocompatible hydrogels can be sensitive in diagnosing DED, and the designed hydrogels can also improve the drug bioavailability and retention time for more effective and long-term treatment. This review summarizes recent advances in the use of hydrogels for diagnosing and treating dry eye, aiming to provide a novel reference for the eventual clinical translation of hydrogels in the context of dry eye disease.

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Section: Hydrogel Eye Drops For Dry Eye Treatmentmentioning

confidence: 99%

Recent Advances in Hydrogels for the Diagnosis and Treatment of Dry Eye Disease

Cao

Wang

2022

Gels

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“…Laccase-Based Biosensor Encapsulated in a Galactomannan-Chitosan Composite [148] Ti 3 C 2 T X MXene/Chitosan Nanocomposite-Based Amperometric Biosensor [149] Glucose oxidase-chitosan immobilized paper biosensor [150] Diffraction-based chitosan leaky waveguide (LW) biosensors [151] Carboxymethyl chitosan assembled piezoelectric biosensor [152] Au nanoparticles/MoS 2 nanosheets-Chitosan modified screen-printed electrode as chlorpyrifos biosensor [153] Temperature-sensitive poly(N-isopropylacrylamide)-chitosan hydrogel for fluorescence sensors [154] Table 1.…”

Section: Materials Referencesmentioning

confidence: 99%

Chitosan-Based Nanocomposites for Biological Applications

Yalçın¹,

Çankaya²

2022

Nanoclay - Recent Advances, New Perspectives and Applications

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Chitosan is an important natural cationic polymer. Chitosan is produced as a deacetylated form of chitin, and its excellent biocompatible, biodegradable, nontoxic, natural chemical, and thermal stability properties have led to its common use in especially biomedical applications. The combination of nanomaterials and chitosan has been considered an excellent approach to overcoming the handicaps associated with biopolymer. The chitosan-based nanocomposites are potentially efficient in a number of areas including medical fields. Chitosan is biodegradable, biocompatible, basic, nontoxic, and also approved by GRAS (Generally recognized as safe by the United States Food and Drug Administration [US FDA]). Chitosan-based nanocomposites have different applications in drug delivery including ocular, per-oral, pulmonary, nasal mucosal, gene, buccal drug, vaccine, vaginal, and cancer therapy. Chitosan has low toxicity in both in vitro and in vivo models. In this chapter, we discussed the preparation techniques and various forms of chitosan materials in biomedical applications. In addition, this chapter explores recent research on chitosan-based nanocomposites for medical studies.

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“…CS-graft-PNIPAm hydrogels have been studied to increase the oral administration of drugs with low solubility, such as caffeine [227], naproxen [228] and paclitaxel [229], and to promote mucosal administration of hydrophobic drugs [230]. Nano-and microgels have been proposed for oncological applications for the delivery of curcumin [224] and 5-fluorouracil [223] and for antibacterial applications [231]. The utilization of fluorescent drugs enclosed in multifunctional inorganic materials consisting of Fe 3 O 4 magnetic nanoparticles, CdTe quantum dots embedded in a mesoporous silica as the core and CS-g-PNIPAM as the shell has been proposed for theranostic applications [232,233].…”

Section: Chitosan-graft-poly-n-isopropylacrylamidementioning

confidence: 99%

Chitosan-Based Biocompatible Copolymers for Thermoresponsive Drug Delivery Systems: On the Development of a Standardization System

Marsili

Berti

et al. 2021

Pharmaceutics

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Chitosan is a natural polysaccharide that is considered to be biocompatible, biodegradable and non-toxic. The polymer has been used in drug delivery applications for its positive charge, which allows for adhesion with and recognition of biological tissues via non-covalent interactions. In recent times, chitosan has been used for the preparation of graft copolymers with thermoresponsive polymers such as poly-N-vinylcaprolactam (PNVCL) and poly-N-isopropylamide (PNIPAM), allowing the combination of the biodegradability of the natural polymer with the ability to respond to changes in temperature. Due to the growing interest in the utilization of thermoresponsive polymers in the biological context, it is necessary to increase the knowledge of the key principles of thermoresponsivity in order to obtain comparable results between different studies or applications. In the present review, we provide an overview of the basic principles of thermoresponsivity, as well as a description of the main polysaccharides and thermoresponsive materials, with a special focus on chitosan and poly-N-Vinyl caprolactam (PNVCL) and their biomedical applications.

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Temperature-sensitive poly(N-isopropylacrylamide)-chitosan hydrogel for fluorescence sensors in living cells and its antibacterial application

Cited by 29 publications

References 30 publications

Recent Advances in Hydrogels for the Diagnosis and Treatment of Dry Eye Disease

Recent Advances in Hydrogels for the Diagnosis and Treatment of Dry Eye Disease

Chitosan-Based Nanocomposites for Biological Applications

Chitosan-Based Biocompatible Copolymers for Thermoresponsive Drug Delivery Systems: On the Development of a Standardization System

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