Temperature sensitivity of suicidal erythrocyte death

Föller, Michael; Braun, Manuel; Qadri, Syed M.; Lang, Elisabeth; Mahmud, Hasan; Läng, Florian

doi:10.1111/j.1365-2362.2010.02296.x

Cited by 35 publications

(35 citation statements)

References 48 publications

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“…However, the finding disagreed with that of Abdelatif et al (2009), who reported higher MCV values in Nubian goats of Sudan during summer than in winter. The decrease in MCV (average size of the erythrocytes) during the HDS may be due to an increase in the number of erythrocyte membrane vesicles formed and shed from the erythrocytes as a result of elevation in body temperature, with a resultant decrease in the size of the parent erythrocytes (Foller et al, 2010;Moore et al, 2013;Habibu et al, 2017). Thus, it is logical to infer that a decrease in MCV may have the potential of being used as an indicator of heat stress in tropical goats naturally exposed to heat stress.…”

Section: Discussionmentioning

confidence: 99%

Influences of breed, sex and age on seasonal changes in haematological variables of tropical goat kids

et al. 2017

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Abstract. The influences of breed, sex and age on seasonal changes in haematological variables of kids (1-4 months old) belonging to Red Sokoto (n = 60) and Sahel (n = 60) goats were studied at the peaks of the cold-dry, hot-dry and rainy seasons in a West Africa Guinea savanna climate. The results showed that, during the hot-dry season, Sahel goat kids had significantly higher (P < 0.05) packed cell volume (PCV) and red blood cell (RBC) count but lower (P < 0.05) mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC) and total leucocyte count than Red Sokoto kids. Similarly, younger kids of both breed had significantly higher (P < 0.05) PCV and RBC but lower MCV, MCH and MCHC compared with the older kids during the hot-dry season. Younger kids (1-2 months) of both breeds exhibited significantly (P < 0.05) high PCV and RBC but low MCH and MCHC during the hot-dry season as compared with the cold-dry and rainy seasons, with the magnitude of the change being greater in Sahel kids. More remarkable seasonal fluctuations in haematological parameters were observed in buck kids than doe kids of both breeds. Multivariate analysis revealed a clear distinction between the change in haematological parameters during the cold-dry as compared with the hot-dry and rainy seasons, with MCV having the strongest discriminating power (0.91 * ). In conclusion, breed, age and sex variations in haematological variables of goats were more pronounced in the hot-dry season, during which the seasonal changes were more dramatic in kids of Sahel goats, as well as in younger and male kids of both breeds. These findings may be useful in the management of tropical goat kids in different seasons.

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Section: Discussionmentioning

confidence: 99%

Influences of breed, sex and age on seasonal changes in haematological variables of tropical goat kids

et al. 2017

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“…Similarly, exposure to natural heat stress has been reported to cause an increase in MCV of Brazilian Azul goats (Ribeiro et al 2015) and Piemontese cattle (Mazzullo et al 2014). The decrease in MCV during the heat stress of the HDS may be due to an increase in body temperature, which causes an increase in the number of erythrocyte membrane vesicles formed and shed from the erythrocytes with a resultant decrease in the size of the parent erythrocytes (Foller et al 2010;Moore et al 2013). This suggests that decrease in MCV may have the potential of being used as an animal-based indicator of heat stress in tropical goats naturally exposed to heat stress.…”

Section: Haematological Parametersmentioning

confidence: 95%

Influence of seasonal changes on physiological variables, haematology and serum thyroid hormones profile in male Red Sokoto and Sahel goats

Habibu

Kawu

Aluwong

et al. 2016

Journal of Applied Animal Research

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The aim of this study was to evaluate the physiological responses of adult male Red Sokoto goats (n = 10; indigenous to the Guinea Savannah climate) and Sahel goats (n = 10; indigenous to the Sahel climate) at the peak of the cold-dry (CDS), hot-dry (HDS) and rainy seasons prevailing in the Guinea Savannah zone of Nigeria. Results revealed that Red Sokoto goats had significantly higher rectal temperature (RT), PCV, red blood cell (RBC), Hb, thyroxin (T 4 ), but lower respiratory rate (RR) and total leucocyte count (TLC) than Sahel goats during the CDS. Comparison within breeds for the three seasons showed that both breeds exhibited the highest (P < .05) PR, RT, neutrophil-lymphocyte ratio (N:L), but lower mean corpuscular volume and triiodothyronine (T 3 ) during the HDS. In addition, Red Sokoto goats showed higher (P < .05) RR and T 4 , but lower RBC, Hb, lymphocyte counts and T 3 :T 4 . However, Sahel goats exhibited higher (P < .05) PCV, RBC, erythrocyte osmotic fragility, but lower circulating T 4 . It was concluded that the cold and hot seasons exerted different physiological effects on the two breeds of goats with marked variation in RT, composition of blood cellular components, thyroid physiology and erythrocyte membrane integrity. ARTICLE HISTORY

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“…Eryptosis contributes to the pathophysiology of several diseases (29), such as diabetes mellitus, renal insufficiency, iron deficiency, phosphate depletion, hemolytic uremic syndrome, sepsis, sickle cell disease, malaria, Wilson's disease, and presumably metabolic syndrome (7,16,29,32,49,59). Ceramide formation significantly contributes to the stimulation of eryptosis in several of those diseases including hemolytic uremic syndrome, sepsis, fever, and Wilson disease (16,29).…”

mentioning

confidence: 99%

“…Ceramide formation significantly contributes to the stimulation of eryptosis in several of those diseases including hemolytic uremic syndrome, sepsis, fever, and Wilson disease (16,29). Moreover, ceramide-dependent and -independent eryptosis is triggered by a wide variety of small molecules (4 -7, 14, 15, 18, 19, 27, 29, 41, 44, 45, 49).…”

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confidence: 99%

Sphingomyelinase-induced adhesion of eryptotic erythrocytes to endothelial cells

Abed

Towhid

Mia

et al. 2012

American Journal of Physiology-Cell Physiology

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141

101

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Eryptosis, the suicidal erythrocyte death, leads to cell shrinkage and cell membrane scrambling with phosphatidylserine exposure at the cell surface. Eryptotic erythrocytes adhere to the vascular wall by binding of phosphatidylserine to the CXC chemokine ligand 16 (CXCL16). Stimulators of eryptosis include increased cytosolic Ca 2ϩ activity, energy depletion, and activation of ceramide-producing sphingomyelinase. The present study explored whether sphingomyelinase triggers erythrocyte adhesion to endothelial cells. To this end, human erythrocytes were exposed for 6 h to bacterial sphingomyelinase (1-10 mU/ml) and phosphatidylserine exposure was estimated from fluorescent annexin-V-binding, cell volume from forward scatter in FACS-analysis, erythrocyte adhesion to human umbilical vein endothelial cells (HUVEC) from trapping of labeled erythrocytes in a flow chamber under flow conditions at arterial shear rates, and CXCL16 protein abundance utilizing Western blotting and FACS analysis of fluorescent antibody binding. As a result, sphingomyelinase (Ն1 mU/ml) triggered cell shrinkage, phosphatidylserine exposure and erythrocyte adhesion to HUVEC, effects blunted by Ca 2ϩ removal. Adhesion was significantly blunted by phosphatidylserine-coating annexin-V (5 l/ml), following addition of neutralizing antibodies against endothelial CXCL16 (4 g/ml) and following silencing of the CXCL16 gene with small interfering RNA. Pretreatment of HUVEC with sphingomyelinase upregulated CXCL16 protein abundance. Six hours pretreatment of HUVEC with sphingomyelinase (10 mU/ml) or C6-ceramide (50 M) augmented erythrocyte adhesion following a 30-min treatment with Ca 2ϩ ionophore ionomycin (1 M) or following energy depletion by 48-h glucose removal. Thus exposure to sphingomyelinase or C6-ceramide triggers eryptosis followed by phosphatidylserine-and CXCL16-sensitive adhesion of eryptotic erythrocytes to HUVEC.

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Temperature sensitivity of suicidal erythrocyte death

Abstract: Hyperthermia stimulates Ca(2+) entry into erythrocytes leading to cell shrinkage and PS exposure. As PS-exposing erythrocytes are rapidly cleared from circulating blood, the eryptosis during hyperthermia may cause anaemia.

Cited by 35 publications

References 48 publications

Influences of breed, sex and age on seasonal changes in haematological variables of tropical goat kids

Influences of breed, sex and age on seasonal changes in haematological variables of tropical goat kids

Influence of seasonal changes on physiological variables, haematology and serum thyroid hormones profile in male Red Sokoto and Sahel goats

Sphingomyelinase-induced adhesion of eryptotic erythrocytes to endothelial cells

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