In recent years, increasing attention has been paid to Mie resonance-based dielectric metamaterials. Here, we report a ZnS nanoparticles-based dielectric metamaterials. The permittivity of ground state and excited state of ZnS were calculated by Materials Studio, and the obtained permittivity was used to simulate the light transmission characteristics of ZnS nanoparticles-based Mie metamaterials. ZnS nanoparticles were prepared by solid reaction process, which were dispersed into alcohol solution to get Mie resonance-based metamaterials. The transmission characteristics were measured by UV–Vis spectrophotometer. There is resonance peak both in simulation and experiment and the different electromagnetic response in ground state and excited state indicates that tunable Mie resonance-based metamaterials were fabricated. This work demonstrates the feasibility of fabrication of tunable dielectric metamaterials at optics frequencies which can be used as sensors with chemical methods.