Template Assisted Change in Morphology from Particles to Nanofibers by Side‐by‐Side Electrospinning of Block Copolymers

Jiang, Shaohua; Jin, Qiao; Agarwal, Seema

doi:10.1002/mame.201400059

Cited by 19 publications

(7 citation statements)

References 33 publications

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“…The two parallel working fluids possessed the same electrical properties; however, the fluids only experience a small point of contact when they were pumped out from the spinneret nozzles (“B” in Figure b). According to case studies on side-by-side electrospinning, given that the two electrospinnable fluids are compatible with each other, the large viscosities would ensure sufficient binding forces to resist repelling forces in forming side-by-side straight fluid jets, going through the instable regions, and finally forming the Janus nanostructures. − …”

Section: Results and Discussionmentioning

confidence: 99%

Electrospun Hydrophilic Janus Nanocomposites for the Rapid Onset of Therapeutic Action of Helicid

Wang

Liu

Chen

et al. 2018

ACS Appl. Mater. Interfaces

123

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The oral delivery of active ingredients for the fast onset of therapeutic effects is a well-known method in patients. In this study, a new kind of hydrophilic Janus structural nanocomposite was designed for the rapid dissolution and transmembrane permeation of helicid, an herbal medicine with poor water solubility. A side-by-side electrospinning process characterized by an eccentric spinneret was developed to fabricate the Janus nanocomposites. The morphology, inner structure, incorporated components and their physical states, hydrophilicity, and functional performances of the Janus nanocomposites were investigated. The experimental results demonstrated that an unspinnable fluid (polyvinylpyrrolidone K10-sodium dodecyl sulfate) could be simultaneously treated with an electrospinnable fluid (polyvinylpyrrolidone K90-helicid) to create Janus structural nanocomposites. The prepared Janus nanofibers exhibited linear morphology and notable side-by-side inner structure with all the incorporated components present in an amorphous state. Both the control of monolithic nanocomposites and the Janus composites can provide more than 10-fold the transmembrane rates of crude helicid particles. Compared with monolithic nanocomposites, the Janus nanocomposites exhibited improved hydrophilicity and can further promote the dissolution and transmembrane permeation of helicid for a potentially faster onset of therapeutic actions. The generation mechanisms and functional performance of Janus nanocomposites were suggested. The preparation protocols reported here can provide a useful approach for designing and developing new functional nanocomposites in the form of Janus structures. Meanwhile, the medicated hydrophilic Janus nanocomposites represent a newly developed kind of nano drug delivery system for the fast onset of therapeutic action of orally administered water-insoluble drugs.

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Section: Results and Discussionmentioning

confidence: 99%

Electrospun Hydrophilic Janus Nanocomposites for the Rapid Onset of Therapeutic Action of Helicid

Wang

Liu

Chen

et al. 2018

ACS Appl. Mater. Interfaces

123

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“…This idea, recently explored in literature consists in the design of multicomponent devices able to recruit the best features of fibers and particles into a unique device, without relevant increase of process complexity and resource costs. From technological point of view, electrospraying is quite similar to electrospinning process; process condition may be easily tuned to switch from fibers to particles, by moving from beadless nanofibers to beaded nanofibers until particles alone . Main advantages mainly refer to high versatility of both processes which assure a good control of bulk and surface properties through the use of a wide set of materials from natural or synthetic source, comprising polymers and inorganic ones (i.e.…”

Section: Towards An Integrated Approachmentioning

confidence: 99%

Additive electrospraying: a route to process electrospun scaffolds for controlled molecular release

Guarino

Altobelli

Cirillo

et al. 2015

Polymers for Advanced Techs

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Electrohydrodynamics-i.e. electrospinning, electrospraying and atomization-are gaining a growing interest in drug delivery applications, because of a large number of advantages including improved therapeutic index, localized delivery/targeting and controlled drugs toxicity level. In the past, microstructured platforms fabricated by the assembly of electrospun fibers have demonstrated to exhibit interesting features as bioactive carriers including extended surface area and high molecular permeability because of fully interconnected pore architecture, thus making the opportunity to incorporate a wide range of actives/drugs for different use. In these systems, molecular release occurs via various molecular transport pathways namely diffusion, desorption and scaffold degradation which may be tuned through a careful control of fiber morphology and composition. However, several shortcomings still concern the possibility to incorporate bioactive species, not exposing molecules to fast and/or uncontrolled denaturation, thus preserving biochemical and biological fiber functionalities. In this context, additive electro spraying (AES)-i.e. integration of electrosprayed nanoparticles into electrospun fiber network-is emerging as interesting route to control "separately" release and functional properties of the scaffolds in order to support cell activities by independent cues, during the tissue formation. Here, we describe the current advances on the use of electrospraying and/or electrospinning until more innovative integrated AES approaches to design molecularly loaded platforms able to spatially and timely release active molecules for different use in tissue engineering and molecular targeting.

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“…34,35 It has advantages as sacricial material like easy removal by water treatment or sintering, very small amount addition in the bres, etc. [35][36][37][38] Therefore, in this work, we aimed to prepare high performance PTFE brous membranes with improved mechanical properties and rstly evaluate their mechanical performance under harsh chemical environment. Emulsion electrospinning was adopted and very small amount of ultrahigh molecular weight PEO was used as sacricial polymer.…”

Section: Introductionmentioning

confidence: 99%

Mechanical properties and chemical resistance of electrospun polyterafluoroethylene fibres

et al. 2016

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Template Assisted Change in Morphology from Particles to Nanofibers by Side‐by‐Side Electrospinning of Block Copolymers

Cited by 19 publications

References 33 publications

Electrospun Hydrophilic Janus Nanocomposites for the Rapid Onset of Therapeutic Action of Helicid

Electrospun Hydrophilic Janus Nanocomposites for the Rapid Onset of Therapeutic Action of Helicid

Additive electrospraying: a route to process electrospun scaffolds for controlled molecular release

Mechanical properties and chemical resistance of electrospun polyterafluoroethylene fibres

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