Template-Directed Assembly on an Ordered Microsphere Array

Grego, Sonia; Jarvis, Thomas; Stoner, Brian R.; Lewis, Jay

doi:10.1021/la0468850

Cited by 28 publications

(22 citation statements)

References 17 publications

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“…In addition, colloid lithography has been applied to generate nanoscale topographical features on curvilinear surfaces of microscale particles and scaffolds to create hierarchical topographical biomaterials that are difficult to obtain using conventional methods [39–41, 56]. Combining nanoscale patterned surfaces generated by photolithography and EBL with colloid self-assembly, it is also possible to achieve regular patterns of nanotopography with curvilinear local geometries [59]. Instead of serving as an etching mask, self-assembled colloidal nanoparticle layers can also act as a deposition mask to generate nanotopography with a negative pattern of the colloidal mask [60–62].…”

Section: Fabrication Of Nanotopographical Surfacesmentioning

confidence: 99%

Nanotopographical surfaces for stem cell fate control: Engineering mechanobiology from the bottom

et al. 2014

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Summary During embryogenesis and tissue maintenance and repair in an adult organism, a myriad of stem cells are regulated by their surrounding extracellular matrix (ECM) enriched with tissue/organ-specific nanoscale topographical cues to adopt different fates and functions. Attributed to their capability of self-renewal and differentiation into most types of somatic cells, stem cells also hold tremendous promise for regenerative medicine and drug screening. However, a major challenge remains as to achieve fate control of stem cells in vitro with high specificity and yield. Recent exciting advances in nanotechnology and materials science have enabled versatile, robust, and large-scale stem cell engineering in vitro through developments of synthetic nanotopographical surfaces mimicking topological features of stem cell niches. In addition to generating new insights for stem cell biology and embryonic development, this effort opens up unlimited opportunities for innovations in stem cell-based applications. This review is therefore to provide a summary of recent progress along this research direction, with perspectives focusing on emerging methods for generating nanotopographical surfaces and their applications in stem cell research. Furthermore, we provide a review of classical as well as emerging cellular mechano-sensing and -transduction mechanisms underlying stem cell nanotopography sensitivity and also give some hypotheses in regard to how a multitude of signaling events in cellular mechanotransduction may converge and be integrated into core pathways controlling stem cell fate in response to extracellular nanotopography.

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Section: Fabrication Of Nanotopographical Surfacesmentioning

confidence: 99%

Nanotopographical surfaces for stem cell fate control: Engineering mechanobiology from the bottom

et al. 2014

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“…One can see experimentally the confinement of light propagation from fluorescent PSMS in Kagome structure (Figure 26a) by reference to ordinary hexagonally close-packed PSMS structure on a flat substrate as shown in Figure 26b. 136 In other words, a novel ordered array structure consisting of PSMS would contribute open new research fields of optical waveguide and optical wiring between CPUs or between semiconductor chips. 123,136 It is also possible to repeat the tapered cell procedure, after the first-ordered array structure on the patterned substrate is rotated at 90°.…”

Section: Award Accountsmentioning

confidence: 99%

“…136 In other words, a novel ordered array structure consisting of PSMS would contribute open new research fields of optical waveguide and optical wiring between CPUs or between semiconductor chips. 123,136 It is also possible to repeat the tapered cell procedure, after the first-ordered array structure on the patterned substrate is rotated at 90°. One can obtain the ordered PSMS array structure with branching points, i.e., 90°-corner structure on tetragonally patterned substrate, as shown in the SEM image of Figure 27.…”

Section: Award Accountsmentioning

confidence: 99%

Hybridized Organic Nanocrystals for Optically Functional Materials

Oikawa¹

2011

Bulletin of the Chemical Society of Japan

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Organic nanocrystals (NCs) are in the mesoscopic phase between a single molecule and the corresponding bulk crystals, and are expected to exhibit peculiar optical properties, depending on crystal size and shape. In the present Award Accounts, recent progress on hybridized organic NCs and ordered array structure of encapsulated organic NCs will be introduced in detail for optically functional materials toward next-generation organic device application. Hybrid material (or hybridization) is an important area in current material science. Our attention is now focused on coreshell type hybridized organic NCs, which seem to be the best suited nanostructure for providing novel optoelectronic properties and photonic function induced by coreshell interface interaction. On the other hand, it may be necessary to arrange and integrate organic NCs, including hybridized materials, on a substrate so as to receive and transmit input and output signals by electronically and/or optically accessing organic devices. Hence, encapsulations of organic NCs, patterned substrates, and tapered cell method have been employed suitably to fabricate and control ordered array structure of organic NCs on a substrate. Finally, the future scope in the relevant fields of optoelectronics and photonics will be discussed in brief.

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“…In light of this, square poly(dimethylsiloxane) (PDMS) microwells of 20 μm width were selected for the localization of ELP-PS μbeads of 10 μm diameter on the edge of a microwell. A microwell with a depth of approximately 1.5 μm could contain no more than two μbeads, which was another critical factor in the stabilization of the bead array 19 .…”

Section: Resultsmentioning

confidence: 99%

Microarray of stimuli-responsive microbeads for duplexed immunoassay

et al. 2011

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This paper describes a duplexed immunoassay method based on a functional microbeads (μbeads) array. For selective detection of dual analytes, the μbeads were conjugated with a responsive biopolymer, characterized by a different phase transition temperature. Then, the μbeads modified with elastin-like polypeptides (ELPs) were spatially localized in a single microwell through sequential injection with a buffer. Prostate specific antigen (PSA) and mouse immunoglobulin G (IgG) were selected to show the feasibility of duplexed immunoassay. The detection limit of the μbead array with PSA and mouse IgG was 0.05 ng/mL and 0.1 ng/mL, respectively.

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Template-Directed Assembly on an Ordered Microsphere Array

Cited by 28 publications

References 17 publications

Nanotopographical surfaces for stem cell fate control: Engineering mechanobiology from the bottom

Nanotopographical surfaces for stem cell fate control: Engineering mechanobiology from the bottom

Hybridized Organic Nanocrystals for Optically Functional Materials

Microarray of stimuli-responsive microbeads for duplexed immunoassay

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