Template Stripping Method-Based Au Nanoarray for Surface-Enhanced Raman Scattering Detection of Antiepileptic Drug

Abstract

Surface-enhanced Raman scattering (SERS) is a potential candidate for highly sensitive detection of target molecules. A SERS active substrate with a noble metal nanostructure is required for this. However, a SERS active substrate requires complicated fabrication procedures. This in turn makes it difficult to fabricate highly sensitive SERS active substrates with high reproducibility. To overcome this difficulty, a plasmonic crystal (PC) with periodic noble metal nanostructures was fabricated via the template-stripping method using a polymer-based template. Using SERS active substrates, SERS was successfully achieved using the PC by detecting low concentrations of phenobarbital which is an antiepileptic drug using a commercially available portable Raman module. The PC can be fabricated by demolding the deposited gold layer from a polymer-based template. This method is rapid, economic, and has high reproducibility. SERS can be achieved easily using this PC for a wide variety of applications such as medical, pharmaceutical, and environmental protection.

Interpol Review of Drug Analysis 2019-2022

“…2019 Electrochemical characterization and voltammetric determination of benzoyl derivatives of phenobarbital using glassy carbon electrode [ 238 ]; sensor for detection of phenobarbital [ 239 ]; 2020 SERS method for detecting low concentrations of phenobarbital using a commercially available portable Raman module [ 240 ]; 2022 electrochemical sensor for determination of phenobarbital [ 241 ]; fluorescence nanoprobe for the detection of phenobarbital [ 242 ]; sensor for determination of phenobarbital in pharmaceutical, blood and urine samples [ 243 ].…”

A Surface-Enhanced Raman Spectroscopic Sensor Pen

“…These processes require a more time-consuming immersion of the paper in concentrated NPs. Shuai [16] fixed gold nanostars onto filter paper to make a SERS substrate. And they used crystal violet as the Raman probe molecule.…”

Noble Metallic Pyramidal Substrate for Surface-Enhanced Raman Scattering Detection of Plasmid DNA Based on Template Stripping Method

“…Surface-enhanced Raman spectroscopy (SERS) is a potent noninvasive spectroscopy technology that can detect and characterize small organic molecules and large biomolecules at very low concentrations and at a single-molecule level. Molecular identification in a low-concentration sample aqueous solution provides the potential for the unlabeled detection and identification of various analytes [ 1 , 2 , 3 , 4 ]. Since the discovery of SERS on the surface of noble metals, a new era of Raman spectroscopy has emerged.…”