Template synthesis and spectroscopic characterization of 16-membered [N₄] Schiff-base macrocyclic complexes of Co(II), Ni(II), Cu(II), and Zn(II):in vitroDNA-binding studies

Mono- and binuclear copper(II) complexes of the bipyridine ligand: Structural, electrochemical and biological studies

“…The presence of axial ligands (acetate, perchlorate and chloride groups) and the hydrophobic property of the rigid complex facilitate the DNA binding [57,58]. The K app values imply that all the complexes can strongly interact with DNA and are protected by DNA efficiently, since the hydrophobic environment inside the DNA helix reduces the accessibility of solvent water molecules to the complex and the complex's mobility is restricted at the binding site [59].…”

DNA interaction studies of d9 and d10 metal complexes having Schiff base and polypyridyl ligands

“…These K b values are lower than those observed for classical intercalators (e.g. EB-DNA, $10 6 (mol L À1 ) À1 ) [38], but have the same level as those of some well-established intercalation agents ($10 4 ) [39][40][41][42]. Better binding affinity of phen complexes to ct-DNA than bpy complexes may be due to the extended aromaticity and coplanarity of the phenanthroline ring system for better stacking between the base pairs of DNA [43].…”

Syntheses, crystal structures, and spectroscopic properties of copper(II) complexes with 3,14-diethyl-2,6,13,17-tetraazatricyclo(16.4.0.07,12)docosane

“…The stereochemistry of copper(II) may be considered as square planar or tetragonally octahedral, depending upon whether or not the out of plane oxygen atoms of water are bonded to copper [32,33]. The concept of semi-coordinated bond was introduced to describe a situation where the polyatomic anion or ligand occupy the long tetragonal position in an otherwise square planar copper(II) complex with an atom in the range of 2.5-3.0 Å [8][9][10]33] Macrocyclic copper(II) 3485 as tetragonally distorted with four nitrogen atoms from the macrocycle and two oxygen atoms of nitrate or water. The tetragonally elongated geometry is common to sixcoordinate Cu(II) complexes involving non-equivalent ligands, and the distortion arises from the pseudo Jahn-Teller effect operative on the d 9 metal center [39,40].…”

“…Different neutral donors have been incorporated into the macrocyclic ligand backbone [8][9][10]; 1,4,8,11-tetraazacyclotetradecane (cyclam: AMD1498), xylyl-biscyclam (AMD3100), and their metal complexes have been reported to exhibit anti-HIV effects and to stimulate activity of stem cells from bone marrow [11][12][13]. The cyclam derivatives inhibit the entry of the virus into white cells by binding to CXCR4, a chemokine receptor in the outer membrane.…”