2024
DOI: 10.1021/acs.molpharmaceut.4c00491
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Templated Nucleation of Clotrimazole and Ketoprofen on Polymer Substrates

Michael A. Bellucci,
Lina Yuan,
Grahame R. Woollam
et al.

Abstract: The use of different template surfaces in crystallization experiments can directly influence the nucleation kinetics, crystal growth, and morphology of active pharmaceutical ingredients (APIs). Consequently, templated nucleation is an attractive approach to enhance crystal nucleation kinetics and preferentially nucleate desired crystal polymorphs for solid-form drug molecules, particularly large and flexible molecules that are difficult to crystallize. Herein, we investigate the effect of polymer templates on … Show more

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