Tempol prevents chronic sleep-deprivation induced memory impairment

Alzoubi, Karem H.; Khabour, Omar F.; Albawaana, Amal S.; Alhashimi, Farah H.; Athamneh, Rabaa Y.

doi:10.1016/j.brainresbull.2015.11.017

Cited by 37 publications

(20 citation statements)

References 65 publications

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“…The results of this study shows that chronic REM-sleep deprivation (8hrs/day for 6 weeks) was associated with hippocampus dependent spatial memory impairment and this was supported by previous studies [9,11,12,15,44]. Also, it was reported that 24hrs of acute REM-sleep deprivation using the modified multiple platform model resulted in short-term memory impairment in RAWM [1].…”

Section: Discussionsupporting

confidence: 85%

“…The duration of L-carnitine treatment used in the current study was based on our previous work with other antioxidants such as vitamin E [13], vitamin C [44], and tempol [9], where similar duration of treatment and REM-sleep deprivation (six weeks) was used. Testing different durations of treatment will be the matter of our future work.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, REM-sleep deprivation impaired long-term potentiation in the hippocampus, which is considered a common cellular correlate of learning and memory functions [2,3,28,42]. REMSleep deprivation also elevated hippocampal oxidative stress, which was correlated with impairment of cognitive functions [9,11,14,15,59].…”

Section: Introductionmentioning

confidence: 97%

“…It can also be chronic sleep deprivation, where it includes daily sleep deprivation for several hours, typically 3-8 hrs/day; that lasts for weeks or months [11,13,29,44]. Multiple studies on human subjects and animal have shown that both acute [1,2,5,60,62,72] and chronic [9,11,12,15] REM-sleep deprivation produced memory defects in a number of behavioral tasks. Additionally, REM-sleep deprivation impaired long-term potentiation in the hippocampus, which is considered a common cellular correlate of learning and memory functions [2,3,28,42].…”

Section: Introductionmentioning

confidence: 98%

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L-carnitine prevents memory impairment induced by chronic REM-sleep deprivation

Alzoubi

Rababa’h

Owaisi

et al. 2017

Brain Research Bulletin

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

L-carnitine prevents memory impairment induced by chronic REM-sleep deprivation

Alzoubi

Rababa’h

Owaisi

et al. 2017

Brain Research Bulletin

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“…In rodent models, chronic sleep restriction paradigms involve extended sleep deprivation protocols frequently continuing for multiple weeks or months (Alzoubi et al, 2012; Rothman et al, 2013; Zielinski et al, 2013; Alzoubi et al, 2016) making it difficult to isolate the time points at which to resolve the molecular consequences of sleep deprivation. As the first step in establishing a simple model system in which the interactions between chronic sleep restriction and memory could be investigated at the molecular and cellular levels, we investigated the effects of chronic sleep deprivation on the induction of short-term (STM) and long-term (LTM) associative memory using a relatively simple invertebrate model system, Aplysia californica .…”

Section: Introductionmentioning

confidence: 99%

Chronic sleep deprivation differentially affects short and long-term operant memory in Aplysia

Krishnan

Noakes

Lyons

2016

Neurobiology of Learning and Memory

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The induction, formation and maintenance of memory represent dynamic processes modulated by multiple factors including the circadian clock and sleep. Chronic sleep restriction has become common in modern society due to occupational and social demands. Given the impact of cognitive impairments associated with sleep deprivation, there is a vital need for a simple animal model in which to study the interactions between chronic sleep deprivation and memory. We used the marine mollusk Aplysia californica, with its simple nervous system, nocturnal sleep pattern and well-characterized learning paradigms, to assess the effects of two chronic sleep restriction paradigms on short-term (STM) and long-term (LTM) associative memory. The effects of sleep deprivation on memory were evaluated using the operant learning paradigm, learning that food is inedible, in which the animal associates a specific netted seaweed with failed swallowing attempts. We found that two nights of 6 h sleep deprivation occurring during the first or last half of the night inhibited both STM and LTM. Moreover, the impairment in STM persisted for more than 24 hours. A milder, prolonged sleep deprivation paradigm consisting of 3 consecutive nights of 4 h sleep deprivation also blocked STM, but had no effect on LTM. These experiments highlight differences in the sensitivity of STM and LTM to chronic sleep deprivation. Moreover, these results establish Aplysia as a valid model for studying the interactions between chronic sleep deprivation and associative memory paving the way for future studies delineating the mechanisms through which sleep restriction affects memory formation.

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Melatonin upregulates BMAL1 to attenuate chronic sleep deprivation‐related cognitive impairment by alleviating oxidative stress

YIN

Yang

2022

Brain and Behavior

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Purpose: To investigate the mechanism underlying the regulatory effect of melatonin on chronic sleep deprivation-related cognitive impairment.Methods: Chronic sleep deprivation (CSD) model was established using the MMPM method. After the model was established, melatonin receptor agonist and inhibitor were given, respectively. Water maze was conducted to record the escape latency and the duration of crossing the platform of space exploration. The concentration of TNF-α, IL-6, MDA, and SOD was measured by ELISA. Immunofluorescence was used to determine the expression level of CD86 and CD206, while the mRNA expression of Bax, Bcl-2, P65, IκB, and BMAL1 was detected by qPCR. Western blotting assay was utilized to determine the protein expression of Bax, Bcl-2, P65, p-P65, IκB, p-I κB, and BMAL1.Results: Compared with the control, the escape latency was greatly increased on the second and third day, accompanied by the increased expression of TNF-α, IL-6, MDA, and SOD in serum. Furthermore, dramatically upregulated Bax, Bcl-2, P65, IκB, and CD86 were observed in the model group, accompanied by the declined expression level of BMAL1 and CD206. Compared with the model group, the escape latency was declined, the concentration of TNF-α, IL-6, MDA, and SOD was decreased, the expression level of Bax, Bcl-2, P65, IκB, and CD86 was declined, and the level of BMAL1 and CD206 was promoted by the treatment of the melatonin agonist, while the opposite results were observed under the treatment of the melatonin inhibitor. Conclusion:Melatonin upregulates BMAL1 to attenuate chronic sleep deprivationrelated cognitive impairment by alleviating oxidative stress.

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Tempol prevents chronic sleep-deprivation induced memory impairment

Cited by 37 publications

References 65 publications

L-carnitine prevents memory impairment induced by chronic REM-sleep deprivation

L-carnitine prevents memory impairment induced by chronic REM-sleep deprivation

Chronic sleep deprivation differentially affects short and long-term operant memory in Aplysia

Melatonin upregulates BMAL1 to attenuate chronic sleep deprivation‐related cognitive impairment by alleviating oxidative stress

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